COMBINED AND ORGAN-PROTECTIVE ANTI-HYPERTENSION THERAPY: POSSIBILITIES OF FIXED COMBINATION OF NITRENDIPINE AND ENALAPRIL
https://doi.org/10.21518/2079-701X-2016-13-28-33
Abstract
In Russia arterial hypertension (AH) is an important factor of development of cardiovascular diseases and mortality. On the whole, the AH incidence is within the 30-45% range of the total population, with the sharp increase with ageing (ESH/ESC 2013). In Russia, 40% of adult population have increased arterial pressure (AP) (AP >140/90 mm Hg), among them 40.5% of women and 38.0% of men [1, 2].
About the Authors
A. G. EVDOKIMOVARussian Federation
MD, Prof.
G. V. ARKADIEVA
Russian Federation
MD, Prof.
V. V. EVDOKIMOV
Russian Federation
А. N. DOBASHIN
Russian Federation
PhD in medicine
References
1. Рекомендации ESH/ESC 2013г. по лечению артериальной гипертонии. Системные Гипертензии, 2013. 3: 1-37./Recommendations ESH/ESC 2013 on therapy of arterial hypertension. Sistemniye Gipertenzii, 2013, 3: 1-37.
2. Российское медицинское общество по артериальной гипертонии (РМОАГ), Всероссийское научное общество кардиологов (ВНОК). Диагностика и лечение артериальной гипертонии. Российские рекомендации (четвертый пересмотр). Системные гипертензии, 2010. 3: 5-26./Russian Medical Arterial Hypertension Society (RMAHS), All-Russian Scientific Cardiologist Association (ARSCA). Diagnostics and therapy of arterial hypertension. Russian Recommendations (fourth revision). Sistemniye Gipertenzii, 2010. 3: 5-26.
3. Евдокимова А.Г., Евдокимов В.В., Теблоев К.И., Ложкина М.В. Антигипертензивная эффективность и влияние на состояние органов-мишеней комбинированной терапии. Справочник поликлинического врача, 2014. 10: 4-7./Evdokikova A.G., Evdokimov V.V., Tebloeb K.I., Lozhkina M.V. Antihypertensive effectiveness and effect on the state of target organs of combined therapy. Spravochnik poliklinicheskogo vracha, 2014. 10: 4-7.
4. Леонова М.В., Белоусов Ю.Б., Штейнберг Л.Л. и др. Фармакоэпидемиология артериальной гипертонии в России (по результатам исследования ПИФАГОР III). Рос. ардиол. Журнал, 2011. 2(88): 9-16./Leonova M.V., Belousov Y.B., Shteinberg L.L. et al. Drug epidemiology of arterial hypertension in Russia (by results of study PIFAGOR S). Ros. Kardiol. Journal, 2011. 2(88): 9-16.
5. Clinical management of primary hypertevsion in adults. NICE clinical guideline. 2011.
6. Jamerson K, Devereux R, Bakris GL et al. Benazepril plus amlodipin or hydrochlorthiazide for hypertension in high-risk patients. N. Engl. J Med, 2008. 359: 2417-28.
7. Roca-Cusachs A, Torres F, Horas M et al. Nitrendipine and enalapril combination therapy in mild to moderate hypertension: assessment оf dose-response relationship by a clinical trial of factorial design. J Cardiovasc Pharmacol, 2001. 38(6): 840-9.
8. Wald DS, Law M, Morris JK et al. Combination therapy vs. Monotherapy in reducing blood pressure : meta-analisis on 11000 participants from 42 trials. Am J Meed, 2009. 122: 290- 300.
9. Staessen JA, Fagard R, Thijs L et al Randomized double – blind comparison of placebo and active treatment or older patients with isolated systolic hypertension. Lancet, 1997. 350: 757-64.
10. Thijs L, Staessen JA, Beleva S et al. How well can blood pressure be controlled? Progress report on the Systolic Hypertension in Europe Follow-Up Study (Syst-Eur 2). Curr Control rials Caardiovasc Med, 2001. 2: 298-306.
11. Tuonmilehto J et al. Effects of calcium – channel blockade in older patients with diabetes and systolic hypertension. Systolic Hypertension in Europe Trial Investigators. N Engl J Med, 1999. 340: 677-84.
12. Thijs L, Richart T, de Leeuw P et al. Morbidity and mortality on combination versus monotherapy: a posthoc analysis of the Systolic Hypertension in Europe trial. Hypertens, 010. 28(4): 865-74.
Review
For citations:
EVDOKIMOVA AG, ARKADIEVA GV, EVDOKIMOV VV, DOBASHIN АN. COMBINED AND ORGAN-PROTECTIVE ANTI-HYPERTENSION THERAPY: POSSIBILITIES OF FIXED COMBINATION OF NITRENDIPINE AND ENALAPRIL. Meditsinskiy sovet = Medical Council. 2016;(13):28-33. (In Russ.) https://doi.org/10.21518/2079-701X-2016-13-28-33