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Медицинский Совет

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Новые возможности терапии интенсивно-предлеченных пациентов с метастатическим колоректальным раком

https://doi.org/10.21518/2079-701X-2016-10-24-32

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Аннотация

Статья посвящена результатам изучения нового мультикиназного ингибитора регорафениба у больных рефрактерным метастатическим раком толстой кишки. По данным двух рандомизированных исследований III фазы, препарат достоверно увеличивает общую выживаемость, выживаемость без прогрессирования и контроль заболевания больных мКРР с прогрессированием после предшествующей стандартной химио- и таргетной терапии. Эффективность регорафениба не зависела от статуса KRAS опухоли, других биомаркеров, а также режимов предшествующей терапии и проведенных ранее линий лечения: выигрыш в выживаемости регистрировался во всех подгруппах пациентов. Основными нежелательными явлениями в группе регорафениба были ладонно-подошвенный синдром, слабость, диарея, анорексия, изменения голоса, повышение артериального давления, мукозит и сыпь/шелушение. Большинство нежелательных явлений регистрировались в начале курса лечения и хорошо контролировались за счет снижения дозы или временного прекращения приема препарата, кумулятивной токсичности не отмечено. Две широкомасштабные наблюдательные программы подтвердили эффективность регорафениба в реальной клинической практике. 

Об авторе

Е. В. АРТАМОНОВА
Российский онкологический научный центр им. Н.Н. Блохина Минздрава России
Россия

д.м.н.

Москва



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ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)