Preview

Meditsinskiy sovet = Medical Council

Advanced search

The clinical, diagnostic and therapeutic aspects of amnestic mild cognitive impairment

https://doi.org/10.21518/2079-701X-2015-5-40-45

Abstract

The article examines the prevalence, causes and main clinical manifestations of amnestic mild cognitive impairment - a syndrome which in most cases is the first manifestation of the neurodegenerative Alzheimer's disease. Diagnostic approaches and the possibility of differential diagnosis are highlighted. There is data on the effectiveness of the glutamate NMDA-receptors antagonist - memantine - in patients with moderate cognitive impairment. The efficacy and safety of Akatinol Memantine as a medication to improve cognitive function is highlighted.

About the Author

N. N. Koberskaya
the First Moscow State Medical University named after I.M. Sechenov
Russian Federation


References

1. Гаврилова С.И. Мягкое когнитивное снижение - доклиническая стадия болезни Альцгеймера? Cons Med, 2004, 2: 153- 156.

2. Захаров В.В., Яхно Н.Н. Синдром умеренных когнитивных расстройств в пожилом возрасте: диагностика и лечение. Рус. мед. журн., 2004, 10: 573-576.

3. Захаров В.В., Яхно Н.Н. Нарушения памяти. М.: ГЭОТАР-Медиа, 2003, 150.

4. Левин О.С. Когнитивные нарушения в практике невролога. М., 2006.

5. Левин О.С. Диагностика и лечение умеренно выраженных когнитивных нарушений в пожилом возрасте. Журн. неврол. и психиат., 2006, 8: 42-49.

6. Левин О.С., Голубева Л.В. Гетерогенность умеренного когнитивного расстройства: диагностические и терапевтические аспекты. €onsilium medicum, 2006, 12: 106-110.

7. Левин О.С., Сагова М.М., Голубева Л.В. Факторы, влияющие на качество жизни больных дисциркуляторной энцефалопатией с умеренным когнитивным расстройством. Рос мед. журн., 2006, 3: 25-29.

8. Локшина А.Б. Легкие и умеренные когнитивные расстройства при дисциркуляторной энцефалопатии: дисс.. канд. мед. наук. М., 2005.

9. Успенская О.В., Яхно Н.Н. Влияние мемантина на когнитивные функции пациентов с амне-стическим вариантом синдрома умеренных когнитивных расстройств (клинико- психологическое и нейрохимическое исследование). Неврол.журн., 2009, 14(3): 37-40.

10. Яхно Н.Н., Захаров В.В., Локшина А.Б. Синдром умеренных когнитивных нарушений при дисциркуляторной энцефалопатии. Журн. неврол. и психиатр., 2005, 105(2): 13-17.

11. Яхно Н.Н., Локшина А.Б., Захаров В.В. Легкие и умеренные когнитивные расстройства при дисциркуляторной энцефалопатии. Клин. геронтол., 2005, 11(9): 38-9.

12. Яхно Н.Н., Преображенская И.С., Захаров В.В. и др. Эффективность акатинола мемантина у пациентов с недементными когнитивными расстройствами. Результаты многоцентрового клинического наблюдения. Неврол. журн. 2010, 15(2): 52-8.

13. Яхно Н.Н. Когнитивные расстройства в неврологической клинике. Неврол. журн., 2006, 11(1): 4-12.

14. Ambrozi L, DanieLczyk W. Treatment of impaired cerebral function in psychogeriatric patients with memantine: results of a phase II doubLe-bLind study. Pharmacopsychiatry, 1998, 21: 144-146.

15. Cowburn R, Hardy J, Roberts P, Briggs R. Presynaptic and postsynaptic gLutamatergic function in Alzheimer's disease. Neurosci. Lett., 1998, 86: 109-113.

16. Crook T, Bartus R, Ferris SH et aL. Age associated memory impairment: proposed diagnostic criteria and measures of cLinicaL change. Report of NationaL Institute of MentaL HeaLthWork Group. DevNeuropsy, 1986, 2: 261-76.

17. Danysz W, Parsons CG, Mobius HJ, et aL. Neuroprotective and synptomatoLogicaL action of memantine reLevant for ALzheimer's disease -A unified gLutamatergic hypothesis on the mechanism of action. Neurotox. Res., 2000, 2: 85-97.

18. Dubois B, ALbert ML. Amnestic MCI or prodromaL ALzheimer's disease. Lancet Neurology, 2004, 3: 246-8.

19. GoLomb J, KLuger A, Garrard P et aL. CLinician's manuaL on miLd cognitive impairment. London: Science Press Ltd. 2001, 56.

20. KraL WA. Senescent forgetfuLLness: benign and maLignant. Can. Med. Assoc., 1962, 86: 257-60.

21. Knopman DS. Current treatement of miLd cognitive impairement an ALzheimer's disesase. Curr Neurol Neurosci Rep., 2006, 6(5): 365-71.

22. Li et aL. NeuroLogicaL soft signs in persons with amnestic miLd cognitive impairment and the reLationships to neuropsychoLogicaL functions. BehavioraL and Brain Functions 2012, 8: 29.

23. MaLek-Ahmadi et aL. Informant-reported cognitive symptoms that predict amnestic miLd cognitive impairment. BMC Geriatrics, 2012, 12: 3.

24. Mark LP, Prost RW, ULmer JL, et aL. PictoriaL review of gLutamate excitotoxicity: FundamentaL concepts for neuroimaging. Amer. J. Neuroradiol. 2001, 22: 1813-1824.

25. Oscar L. Lopez MiLd Cognitive Impairment Continuum (Minneap Minn) 2013, 19(2): 411-424

26. PaLmer K, Wang H-X, Backman L et aL. DifferentiaL evoLution of cognitive impairment in nondemented oLder persons. Am J Psychiatry 2002, 159: 436-42.

27. Petersen RC. MiLd cognitive impairment as a diagnostic entity. J Int Med 2004, 256: 183-194.

28. Petersen RS, Smith GE, Waring SC et aL Aging, memory and miLd cognitive impairment. Int Psychogeriatr 1997, 9: 37-43.

29. Petersen RS, Smith GE, Waring SC et aL. MiLd cognitive impairment: cLinicaL characterization and outcome. Arch Neurol 1999, 56: 303-8.

30. Petersen RC, Stevens JC, GanguLi M et aL. Practice parameter. EarLy detection of dementia: miLd cognitive impairment (an evidence-based review). Report of the OuaLity Standards Subcommittee of the AmericaAcademy of NeuroLogy. Neurology, 2001, 56: 1133-42.

31. Petersen RC, Stevens JC, GanguLi M et aL. MiLd cognitive impairment (an evidencebased review). Neurology 2001, 56: 1131-42.

32. Petersen RS, Touchon J. Consensus on miLd cognitive impairment. Research and practice in ALzheimer's disease, E.A.D.C./A.D.C.S. Joint meetihg 2005, 10: 24-32.

33. Ritchie K, Artero S, Touchon J. CLassification criteria for miLd cognitive impairment: a popuLation-based vaLidation study. Neurology 2001, 56: 37-42.

34. Roberts JS, KarLawish JH, Petersen RC et aL. MiLd cognitive impairment in cLinicaL care. A survey of American Academy of NeuroLogy members. Neurology 2010, 75: 425-431.

35. Teng E, Leone-Friedman J, Lee G. SimiLar Verba! FLuency Patterns in Amnestic MiLd Cognitive Impairment and ALzheimer's Disease. Arch of Cl Neuropsychol., 2013, 28: 400-410.

36. Modrego Pedro J, Fayed N, Sarasa M. Magnetic resonance spectroscopy in the prediction of earLy conversion from amnestic miLd cognitive impairment to dementia: a prospective cohort study. BMJ Open 2011: 1-8.

37. Karakaya T, Fufter F. PharmacoLogicat Treatment of MiLd Cognitive Impairment as a ProdromaL Syndrome of ALzheimer's Disease. Cur. Neuropharm., 2013, 11: 102-108.


Review

For citations:


Koberskaya NN. The clinical, diagnostic and therapeutic aspects of amnestic mild cognitive impairment. Meditsinskiy sovet = Medical Council. 2015;(5):40-45. (In Russ.) https://doi.org/10.21518/2079-701X-2015-5-40-45

Views: 437


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)