НОВАЯ СТРАТЕГИЯ ЛЕКАРСТВЕННОГО ЛЕЧЕНИЯ ЛЮМИНАЛЬНОГО HER2-НЕГАТИВНОГО МЕТАСТАТИЧЕСКОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ
https://doi.org/10.21518/2079-701X-2017-6-30-37
Аннотация
Статья посвящена новому пероральному таргетному препарату палбоциклибу и его месту в терапии эстроген-рецептор-позитивного HER2-негативного метастатического рака молочной железы. Последовательная эндокринотерапия является предпочтительным видом лечения у пациенток этой подгруппы, т.к. существенно улучшает клинические исходы заболевания. Но способность опухоли демонстрировать приобретенную, а иногда и исходную гормонорезистентность приводит рано или поздно к прогрессированию заболевания. Открытие роли циклин-зависимых киназ (CDK) в активации пролиферации опухоли и последующее создание первого ингибитора CDK 4-го и 6-го типов палбоциклиба позволило принципиально изменить сложившуюся ситуацию: результаты клинического изучения комбинаций палбоциклиба с летрозолом или фулвестрантом продемонстрировали двукратное увеличение медианы выживаемости без прогрессирования болезни по сравнению с одной гормонотерапией. Эта стратегия, названная экспертами «терапией прорыва», сочетает в себе доказанную эффективность, хорошую переносимость, позволяет поддерживать высокое качество жизни и должна использоваться у больных с ЭР-позитивным HER2-негативным метастатическим раком молочной железы.
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Рецензия
Для цитирования:
АРТАМОНОВА ЕВ. НОВАЯ СТРАТЕГИЯ ЛЕКАРСТВЕННОГО ЛЕЧЕНИЯ ЛЮМИНАЛЬНОГО HER2-НЕГАТИВНОГО МЕТАСТАТИЧЕСКОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ. Медицинский Совет. 2017;(6):30-37. https://doi.org/10.21518/2079-701X-2017-6-30-37
For citation:
ARTAMONOVA EV. NEW STRATEGY FOR DRUG TREATMENT OF LUMINAL HER2-NEGATIVE METASTATIC BREAST CANCER. Meditsinskiy sovet = Medical Council. 2017;(6):30-37. (In Russ.) https://doi.org/10.21518/2079-701X-2017-6-30-37
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