IMPORTANT FACTORS OF THE INFLAMMATORY PROCESS IN THE O ROPHARYNX AND OPTIMAL TREATMENT REGIMES SELECTION

Acute inflammatory diseases of the oropharynx dominate the medical aid appealability among all age categories. Such diseases are characterized by poly-ethiology and may form a mixed infection with bacteria and respiratory viruses. Components of bacterial cell walls, toxins, decay products of tissues during cytolysis or apoptosis of cells as a result of massive output of mature virions induce epithelial cells and macrophages for active synthesis of chemokines MCP-1, MCP-3, RANTES, IL-8, which leads to increased inflow of polymorphonuclear leukocytesin to the flammatory focus and a mass release of biogenic amines, lysosomal enzymes, cationic proteins, the release of arachidonic acid, which gradually turns into eicosanoids. Systemic use of NSAIDs can cause NSAID-associated gastropathies. Good accessibility of the target organ in diseases of the oropharynx allows target organspecific delivery of local treatment. Benzidamine hydrochloride (Tantum® Verde) refers to the group of anti-inflammatory suppressor of cytokines and also has a pronounced analgesic effect. The article provides data of the follow-up study of the efficacy of Tantum Verde® in the treatment of acute tonsillopharyngitis in outpatient settings.

1. Лопатин А.С. Лечение острого и хронического фарингита. РМЖ, 2001, 9(16): 765–769.

2. Dierig A, Heron LG, Lambert SB, Yin JK et al. Epidemiology of respiratory viral infections in children enrolled in a study of influenza vaccine effectiveness. Influenza and Other Respiratory Viruses, 2014, 8: 293-301.

3. Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G, Martin JM, Van Beneden C. Clinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America. Clin Infect Dis, 2012, 55(10): 1279-82.

4. Савлевич Е.Л., Дорощенко Н.Э. Патогенетическое обоснование топической терапии воспалительной патологии ротоглотки. Фарматека, 2015, 1: 76-79.

5. Маянский А.Н., Маянский Н.А., Заславская М.И. Нуклеарный фактор-κB и воспаление. Цитокины и воспаление, 2007, 6(2): 3-9.

6. Белоцкий С.М., Авталион Р.Р. Воспаление. Мобилизация клеток и клинические эффекты. М.: Бином, 2008. 239 с.

7. Piet B, Bree GJ, Smids-Dierdorp BS, Loos CM, Remmerswaal EB, Thüsen JH. CD8+ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung. J Clin Invest, 2011, 121(6): 2254–2263.

8. Зайчик А.Ш., Чурилов Л.П. Общая патофизиология с основами иммунопатологии. СПб.: ЭЛБИ-СПб, 2005. 656 с.

9. Liu Q, Zhou YH, Yang ZQ. The cytokine storm of severe influenza and development of immunomodulatory therapy. Cell Mol Immunol, 2016, 13(1): 3-10.

10. Клинические рекомендации: острый тонзиллофарингит, КР306. Министерство здравоохранения Российской Федерации, Национальная медицинская ассоциация отоларингологов, 2016 г.

11. Quane PA, Graham GG, Ziegler JB. Pharmacology of benzydamine. Inflammopharmacology. 1998, 6(2): 95-107.

12. Wethington JF. Double-blind study of benzydamine hydrochloride, a new treatment for sore throat. Clin Ther, 1985, 7(5): 641-6.

13. Nathan C et al. Beyond oxidative stress: an immunologist’s guide to reactive oxygen species. Nat Rev Immunol, 2013 May, 13(5): 349–361.

14. Morgan MJ et al. TNFα and reactive oxygen species in necrotic cell death. Cell Research, 2008, 18: 343-349.

15. Rubenstein EB, Peterson DE, Schubert M, Keefe D, McGuire D, Epstein J et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer, 2004, 100: 2026–2046.

16. Зайцев А.А., Карпов О.И., Карпищенко С.А. Флурбипрофен: новые возможности местного лечения тонзиллофарингита. РМЖ, 2004, 17: 1003.

17. Simard-Savoie S, Forest D. Topical anaesthetic activity of benzydamine. Curr Ther Res, 1978, 23(6): 734-745.

18. Engles I. Vertraglichkeits studiemit Tantum Verde gurrgellosung. Med. Welt., 1980. 49: 3-7.

19. Scarpelli PT. Clinical study on analgesico-antiphlogistic activity of af-864 or benzidamine hydrochloride. Clin Ter, 1965 Apr 30, 33: 116-22. Адаптировано: согласно полученным клиническим данным об опыте применения препарата, опубликованным в профессиональных изданиях.