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MANAGEMENT OF PATIENTS AFTER ISCHEMIC STROKE WITH MOTOR DISTURBANCES

https://doi.org/10.21518/2079-701X-2017-17-6-10

Abstract

Management of patients after ischemic stroke is based on the prevention of the repeated ischemic stroke and other cardiovascular diseases.  It’s  necessary to use drugs (antiplatelet  drugs or anticoagulants, statins, antihypertensive drugs), non-drug methods (smoking cessation, alcohol abstinence, rational diet, increase of physical activity), surgical therapy is indicated for a share of patients (carotid endarterectomy). In motor disturbances the remedial gymnastics targeted at training of movements in paretic extremities and prevention of contractures plays the leading role. Currently the effectiveness  of drugs to improve restoration of the motor functions is not proved. Possibilities  of cerebrolysin and results of the recently published study ECOMPASS are discussed, in which effectiveness of cerebrolysin was studied on 70 patients (30 ml intravenously for 7–28 days of IS) versus placebo. Improvement of restoration of the motor functions in a subgroup of patients with pronounced motor disturbances has been observed as well as improvement of neuroplasticity processes by results of the diffuse and tensor and functional magnetic and resonance tomography in use of cerebrolysin (versus placebo). Use of all effective methods in management of patients after ischemic stroke allows reducing the risk of development of repeated stroke, improving the restoration and quality of life of patients.

About the Author

V. A. Parfenov
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

MD, Prof.



References

1. Инсульт: диагностика, лечение и профилактика. Под ред. З.А. Суслиной, М.А. Пирадова. М.: МЕДпресс-информ, 2008.

2. European Stroke Organisation Executive C, Committee ESOW. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc. Dis., 2008, 25: 457–507.

3. Скворцова В.И., Губский В.Л., Стаховская Л.В. с соавт. Ишемический инсульт. В книге: Неврология. Национальное руководство. Под ред. Е.И Гусева, А.Н. Коновалова, В.И. Скворцовой, А.Б. Гехт. М., 2009: 592-614.

4. Парфенов В.А., Хасанова Д.Р. Ишемический инсульт. М., МИА, 2012. 288 с.

5. Meijer R, Plotnik M, Zwaaftink EG et al. Markedly impaired bilateral coordination of gait in post-stroke patients: Is this deficit distinct from asymmetry? A cohort study. J Neuroeng Rehabil, 2011, 8: 23. doi: 10.1186/1743-0003-8-23.

6. Wannamethee SG, Shaper AG, Whincup PH, Walker M. Smoking cessation and the risk of stroke in middle-aged men. JAMA, 1995, 274: 155–160.

7. Lam TH, Li ZB, Ho SY et al. Smoking, quitting, and mortality in an elderly cohort of 56,000 Hong Kong Chinese. Tob Control, 2007, 16: 182-189.

8. Sachdeva A, Chandra M, Choudhary M et al. Alcohol-Related Dementia and Neurocognitive Impairment: A Review Study. Int J High Risk Behav Addict, 2016, 5(3): e27976.

9. Barnes JN. Exercise, cognitive function, and aging. Adv Physiol Educ, 2015, 39(2): 55–62.

10. Lee CD, Folsom AR, Blair SN. Physical activity and stroke risk: a meta-analysis. Stroke, 2003, 34: 2475–2481.

11. Hackam DG. Combining Multiple Approaches for the Secondary Prevention of Vascular Events After Stroke. A Quantitative Modeling Study. Stroke, 2007, 38: 1881-1885.

12. Canevelli M, Lucchini F, Quarata F et al. Nutrition and Dementia: Evidence for Preventive Approaches? Nutrients, 2016, 8(3): 144.

13. Baumgartner R, Oesch L, Sarikaya H. Obesity Paradox and Stroke. Praxis (Bern), 2016, 105(14): 835-841.

14. Verdecchia P, Staessen JA, Angeli F et al: Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial. Lancet, 2009, 374: 525-533.

15. Bath PM, Scutt P, Blackburn DJ et al. Intensive versus Guideline Blood Pressure and Lipid Lowering in Patients with Previous Stroke: Main Results from the Pilot ‘Prevention of Decline in Cognition after Stroke Trial’ (PODCAST) Randomised Controlled Trial. PLoS One, 2017, 12(1): e0164608.

16. Rothwell PM, Howard SC, Spence JD, for the Carotide Endarterectomy Trialist`s Collaboration. Relationship between Blood Pressure and Stroke Risk in Patients With Symptomatic Carotid Occlusive Disease. Stroke, 2003, 34: 2583-2592.

17. Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ, 2002, 324 : 71-86.

18. CAPRIE Streering Commitee. A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet, 1996, 348: 1329-1339.

19. Diener HC, Cunha L, Forbes C et al. European Stroke Prevention Study, 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci, 1996, 143: 1–13.

20. Bhatt D, Fox K, Hacke W et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med, 2006, 354: 1706-1717.

21. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC). European Heart Journal, 2016, 50(5): e1-e88.

22. Amarenco P, Labreuche J, Lavalle´e P, Touboul P-J. Statin in stroke prevention and carotid atherosclerosis : systematic review and meta-analysis. Stroke, 2004, 35: 2902–2909.

23. Kim JH, Sim WS, Won BH. Effectiveness of elastic band-type ankle–foot orthoses on postural control in poststroke elderly patients as determined using combined measurement of the stability index and body weight-bearing ratio. Clinical Interventions in Aging, 2015, 10: 1839–1847.

24. Popovi MD, Kosti MD, Rodi SZ, Konstantinovi LM. Feedback-Mediated Upper Extremities Exercise: Increasing Patient Motivation in Poststroke Rehabilitation. BioMed Research International, 2014: ID 520374.

25. Shaw LC, Price CIM, van Wijck FMJ et al. Botulinum Toxin for the Upper Limb After Stroke (BoTULS) Trial: Effect on Impairment, Activity Limitation, and Pain. Stroke, 2011, 42: 1371-1379.

26. Lim S M, Yoo J, Lee E et al. Acupuncture for Spasticity after Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine, 2015: ID 870398.

27. Galvaõ SCB, dos Santos RBC, dos Santos PB et al. Efficacy of Coupling Repetitive Transcranial Magnetic Stimulation and Physical Therapy to Reduce Upper-Limb Spasticity in Patients With Stroke: A Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation, 2014, 95: 222-229.

28. Kim DH, Shin JC, Jung S et al. Effects of intermittent theta burst stimulation on spasticity after stroke. NeuroReport, 2015, 26: 561–566.

29. Álvarez XA, Fuentes P. Cerebrolysin in Alzheimer’s disease. Drugs Today (Barc), 2011, 47: 487-513.

30. Ren J, Sietsma D, Qiu S, Moessler H, Finklestein SP. Cerebrolysin enhances functional recovery following focal cerebral infarction in rats. Restor Neurol Neurosci, 2007, 25: 25–31.

31. Zhang C, Chopp M, Cui Y et al. Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke. J Neurosci Res, 2010, 88: 3275–81.

32. Plosker GL, Gautheir S. Cerebrolyzin: a review of its use in dementia. Drugs Aging, 2009, 26(11): 893-915.

33. Chen N, Yang M, Guo J et al. Cerebrolyzin for VaD. Cochrane Database Syst Rev, 2013: CD008900.

34. Sayed El, Zaki I, Fayed A et al. A meta-analysis of the effect of different neuroprotective drugs in management of patients with traumatic brain injury. Neurosurg Rev, 2016. doi:10.1007/ s10143-016-0775-y.

35. Muresanu DF, Heiss WD, Hoemberg V et al. Cerebrolysin and Recovery After Stroke (CARS). A Randomized, Placebo-Controlled, DoubleBlind, Multicenter Trial. Stroke, 2016, 47: 3, doi:10.1161/STROKEAHA.115.012181.

36. Chang WH, Park CН, Kim DY et al. Cerebrolysin combined with rehabilitation promotes motor recovery in patients with severe motor impairment after stroke. BMC Neurology, 2016, 16: 31. DOI 10.1186/s12883-016-0553-z.


Review

For citations:


Parfenov VA. MANAGEMENT OF PATIENTS AFTER ISCHEMIC STROKE WITH MOTOR DISTURBANCES. Meditsinskiy sovet = Medical Council. 2017;(17):6-10. (In Russ.) https://doi.org/10.21518/2079-701X-2017-17-6-10

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ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)