CHEMOTHERAPY REGIMEN AC (DOXORUBICIN AND CYCLOPHOSPHAMIDE) IN BREAST CANCER – PREVENTION OF NAUSEA AND VOMITING
https://doi.org/10.21518/2079-701X-2017-14-112-117
Abstract
Chemotherapy regimen AС (doxorubicin and cyclophosphamide) is the most often used in adjuvant chemotherapy of breast cancer. AC regimen is high emetogenic.
Objective – to evaluate the effectiveness of the combination of aprepitant, ondansetron and dexamethasone for the prevention of nausea and vomiting in patients with breast cancer receiving chemotherapy regimen AC.
Materials and methods: 82 female patients with breast cancer received adjuvant chemotherapy regimen AC: doxorubicin 60 mg/ m2, cyclophosphamide 600 mg/m2 in day 1, each 21 day 4 cycle. Patients received an triple-therapy regimen (aprepitant 125 mg p.o. in day 1, 80 mg in days 2 and 3, ondansetron 8 mg i.v. in 1 day, dexamethasone 12 mg i.v.in 1 day, then to 8 mg/day p.o. in days 2–4) for prevention of nausea and vomiting.
Results: During the first cycle of chemotherapy in acute phase (0-24 hours from the start of chemotherapy) complete control of nausea and vomiting was achieved at 72 (87.8%) patients. During delayed phase (25-120 hours from the start of chemotherapy) complete control achieved at 56 (68.3%)patients . 57.3% of patients had complete control of nausea and vomiting during all 4 cycles.
Conclusion: Adequate regimen for prevention of nausea and vomiting is combination of NK1 receptor antagonist, 5-HT3 receptor antagonist and dexamethasone. Triple-therapy regimen allows more than half of the patients undergo 4 cycles of AC without nausea and vomiting.About the Authors
I. A. Koroleva
Medical University Reaviz
Russian Federation
Russian Federation
MD, Prof.
Samara
M. V. Kopp
Medical University Reaviz
Russian Federation
Russian Federation
MD, Prof.
Samara
E. M. Lipaeva
Samara regional clinical oncology dispensary
Russian Federation
Russian Federation
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For citations:
Koroleva IA, Kopp MV, Lipaeva EM. CHEMOTHERAPY REGIMEN AC (DOXORUBICIN AND CYCLOPHOSPHAMIDE) IN BREAST CANCER – PREVENTION OF NAUSEA AND VOMITING. Meditsinskiy sovet = Medical Council. 2017;(14):112-117. (In Russ.) https://doi.org/10.21518/2079-701X-2017-14-112-117
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