ACUTE HEPATITIS С ON THE BACKGROUND OF LIVER Cirrhosis IN THE OUTCOME OF CHRONIC HEPATITIS C: CLINICAL CASE
https://doi.org/10.21518/2079-701X-2017-20-118-123
Abstract
A patient with Child-Pugh B cirrhosis as the outcome of chronic hepatitis C (HCV), genotype 1b was treated with ombitasvir/ paritaprevir/ritonavir/dasabuvir (Viekira Pak) and ribavirin (Ribavirin-SZ) for 12 weeks with achievement of sustained virological response. 48 weeks after the end of the antiviral treatment the patient developed acute viral hepatitis with high level of liver aminotransferases caused by the hepatitis C virus genotype 3a. On day 18 of hospitalization antiviral therapy with sofosbuvir 400 mg per day and daclatasvir 60 mg per day for 12 weeks was administered. Drug tolerance was good, biochemical and sustained virological response was achieved.
About the Authors
V. G. Morozov
Medical Company Hepatolog.
Russian Federation
Russian Federation
MD, Prof.
Samara.
E. S. Malova
Medical Company Hepatolog.
Russian Federation
Russian Federation
MD.
Samara.
L. M. Topornina
Medical Company Hepatolog.
Russian Federation
Samara.
Russian Federation
Samara.
E. V. Jarkova
Medical Company Hepatolog.
Russian Federation
Samara.
Russian Federation
Samara.
A. A. Ribkina
Medical Company Hepatolog.
Russian Federation
Samara.
Russian Federation
Samara.
L. N. Finko
Medical University Reaviz.
Russian Federation
Russian Federation
MD.
Samara.
A. M. Kalishenko
Samara Regional Center for the Prevention and Control of AIDS and Infectious Diseases.
Russian Federation
Samara.
Russian Federation
Samara.
P. E. Tkachenko
First Moscow State Medical University named after I.M.Semashko, MoH RF.
Russian Federation
Moscow.
Russian Federation
Moscow.
A. A. Ishmukhametov
First Moscow State Medical University named after I.M.Semashko, MoH RF; Chumakov Federal Scientific Center for Research and Development of Immune-and- Biological Products of Russian Academy of Sciences.
Russian Federation
MD, Prof, corresponding member of the RAS.
Russian Federation
MD, Prof, corresponding member of the RAS.
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Review
For citations:
Morozov VG, Malova ES, Topornina LM, Jarkova EV, Ribkina AA, Finko LN, Kalishenko AM, Tkachenko PE, Ishmukhametov AA. ACUTE HEPATITIS С ON THE BACKGROUND OF LIVER Cirrhosis IN THE OUTCOME OF CHRONIC HEPATITIS C: CLINICAL CASE. Meditsinskiy sovet = Medical Council. 2017;(20):118-123. (In Russ.) https://doi.org/10.21518/2079-701X-2017-20-118-123
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