ANTIOXIDANT THERAPY IS THE KEY TO THE TREATMENT OF IDIOPATHIC MALE INFERTILITY
https://doi.org/10.21518/2079-701X-2017-20-177-181
Abstract
Idiopathic infertility (II) accounts for up to 30% of male infertility. Antioxidants were empirically used in the treatment of II based on their ability to improve reproductive function suppressed by oxidative stress (OS), which was often found in these patients. The review article was aimed to report the validity of available data confirming the use of antioxidants. Antioxidants such as glutathione, vitamins E and C, carnitines, coenzyme Q10, N-acetylcysteine, selenium, zinc, folic acid and lycopene have been shown to reduce sperm damage caused by OS. Although rigorous scientific evidence in the form of double-blind, placebo-controlled clinical trial is limited, recent systematic reviews and meta-analyses showed a positive effect of antioxidants on sperm parameters and fertility rates. There is, however, a need for further investigation with randomised controlled studies to confirm the efficacy and safety of antioxidant therapy in the medical treatment of idiopathic male infertility as well as the need to determine the effective dose of each compound to improve semen parameters, fertilisation rates and healthy pregnancy outcomes.
About the Authors
R. I. Ovchinnikov
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of Russia.
Russian Federation
Russian Federation
PhD in medicine.
Moscow.
A. Yu. Popova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of Russia.
Russian Federation
Russian Federation
PhD in medicine.
Moscow.
S. I. Gamidov
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of Russia.
Russian Federation
Russian Federation
MD, Prof.
Moscow.
A. V. Kvasov
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of Russia.
Russian Federation
Moscow.
Russian Federation
Moscow.
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Review
For citations:
Ovchinnikov RI, Popova AY, Gamidov SI, Kvasov AV. ANTIOXIDANT THERAPY IS THE KEY TO THE TREATMENT OF IDIOPATHIC MALE INFERTILITY. Meditsinskiy sovet = Medical Council. 2017;(20):177-181. (In Russ.) https://doi.org/10.21518/2079-701X-2017-20-177-181
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