Новые оральные антикоагулянты и коронарная безопасность: есть ли проблема?

Е. М. Нифонтов

doi:10.21518/2079-701X-2018-5-20-25

Новые оральные антикоагулянты и коронарная безопасность: есть ли проблема?

Е. М. Нифонтов

https://doi.org/10.21518/2079-701X-2018-5-20-25

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Аннотация

В аналитическом обзоре представлены сведения о частоте развития инфаркта миокарда при использовании прямых оральных антикоагулянтов в рандомизированных клинических исследованиях и двух наблюдательных когортных исследованиях FDA, опубликованных в 2012 и 2017 гг. Отмечена большая частота инфарктов при применении прямого ингибитора тромбина дабигатрана по сравнению с варфарином. Блокатор Хa-фактора ривароксабан имеет наиболее убедительные доказательства коронарной безопасности.

Ключевые слова

апиксабан, дабигатран, ривароксабан, инфаркт миокарда

Об авторе

Е. М. Нифонтов

Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия
д.м.н., профессор

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