Новые оральные антикоагулянты и коронарная безопасность: есть ли проблема?
Аннотация
В аналитическом обзоре представлены сведения о частоте развития инфаркта миокарда при использовании прямых оральных антикоагулянтов в рандомизированных клинических исследованиях и двух наблюдательных когортных исследованиях FDA, опубликованных в 2012 и 2017 гг. Отмечена большая частота инфарктов при применении прямого ингибитора тромбина дабигатрана по сравнению с варфарином. Блокатор Хa-фактора ривароксабан имеет наиболее убедительные доказательства коронарной безопасности.
Об авторе
Е. М. Нифонтов
Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия
д.м.н., профессор
Россия
д.м.н., профессор
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Для цитирования:
Нифонтов Е.М. Новые оральные антикоагулянты и коронарная безопасность: есть ли проблема? Медицинский Совет. 2018;(5):20-25. https://doi.org/10.21518/2079-701X-2018-5-20-25
For citation:
Nifontov E.M. New oral anticoagulants and cardiac safety: do we have a problem? Meditsinskiy sovet = Medical Council. 2018;(5):20-25. (In Russ.) https://doi.org/10.21518/2079-701X-2018-5-20-25
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