Preview

Медицинский Совет

Расширенный поиск

Витамин Д и репродуктивное здоровье женщин (обзор литературы)

https://doi.org/10.21518/2079-701X-2018-12-164-172

Полный текст:

Аннотация

Поиск литературы о взаимосвязи между витамином Д и фертильностью у женщин проведен в Pubmed. Рецепторы витамина Д (РВД) и витамин-Д-связанные ферменты были найдены в репродуктивных органах мужчин и женщи н. Предоставлены свидетельства, что витамин Д участвует в репродуктивном здоровье женщин, влияя на результаты искусственного оплодотворения и синдром поликистозных яичников (СПЯ). У женщин с СПЯ низкий уровень 25-гидроксивитамина Д (25(OH) Д) связан с ожирением, метаболическими и гормональными нарушениями, а потребление витамина Д может способствовать регуляции менструального цикла и метаболических нарушений. Более того, витамин Д может влиять на стероидогенез половых гормонов (эстрадиола и прогестерона) у здоровых женщин, при этом высокий уровень 25(OH)Д может быть у женщин с эндометриозом.

 

Об авторах

Я. З. Зайдиева
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»
Россия

д.м.н., профессор



В. Е. Балан
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»
Россия
д.м.н., профессор


Список литературы

1. Holick MF. Vitamin D defi ciency. New England Journal of Medicine, 2007, 357: 266-281. doi:10.1056/NEJMra070553.

2. Pilz S, Dobnig H, Winklhofer-Roob B, Riedmiiller G, Fischer JE, Seelhorst U, Wellnitz B, Boehm BO, Marz W. Low serum levels of 25-hydroxyvita-min D predict fatal cancer in patients referred to coronary angiography. Cancer Epidemiology, Biomarkers and Prevention, 2008, 17: 1228-1233. doi:10.1158/1055-9965.EPI- 08-0002.

3. Pilz S, Marz W, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai HP, Boehm BO, Dobnig H. Association of vitamin D defi ciency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. Journal of Clinical Endocrinology and Metabolism, 2008, 93: 3927-3935. doi:10.1210/jc.2008-0784.

4. Benyamini Y, Gozlan M, Kokia E. Variability in the diffi culties experienced by women undergoing infertility treatments. Fertility and Sterility, 2005, 83: 275-283. doi:10.1016/j.fertnstert.2004. 10.014.

5. Thonneau P, Marchand S, Tallec A, Ferial ML, Ducot B, Lansac J, Lopes P, Tabaste JM, Spira A. Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988-1989). Human Reproduction, 1991, 6: 811-816.

6. Forti G, Krausz C. Clinical review 100: evaluation and treatment of the infertile couple. Journal of Clinical Endocrinology and Metabolism, 1998, 83: 4177-4188. doi:10.1210/jc.83.12. 4177.

7. Gyllenborg J, Skakkebaek NE, Nielsen NC, Keiding N, Giwercman A. Secular and seasonal changes in semen quality among young Danish men: a statistical analysis of semen samples from 1927 donor candidates during 1977-1995. International Journal of Andrology, 1999, 22: 28-36. doi:10.1046/j.1365-2605.1999.00137.x.

8. J0rgensen N, Asklund C, Carlsen E, Skakkebaek NE. Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern. International Journal of Andrology, 2006, 29: 54-61. doi:10.1111/j.1365- 2605.2005.00635.x.

9. Zitzmann M. Testosterone defi ciency, insulin resistance and the metabolic syndrome. Nature Reviews. Endocrinology, 2009, 5: 673-681. doi:10.1038/nrendo.2009.212.

10. Wehr E, Pilz S, Boehm BO, Marz W, Obermayer-Pietsch B. Association of vitamin D status with serum androgen levels in men. Clinical Endocrinology, 2010, 73: 243-248. doi:10.1111/j.1365-2265.2010.03852.x.

11. Pilz S, Frisch S, Koertke H, Kuhn J, Дreier J, Ober-mayer-Pietsch B, Wehr E, Zittermann A. Eff ect

12. of vitamin D supplementation on testosterone levels in men. Hormone and Metabolic Research, 2011, 43: 223-225. doi:10.1055/s-0030-1269854.

13. Kovacs CS. Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies. American Journal of Clinical Nutrition, 2008, 88: 520S-528S.

14. Lewis S, Lucas RM, Halliday J, Ponsonby AL. Vitamin Д defi ciency and pregnancy: from preconception to birth. Molecular Nutrition and Food Research, 2010, 54: 1092-1102.

15. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know. Journal of Clinical Endocrinology and Metabolism, 2011, 96: 53-58. doi:10. 1210/jc.2010-2704.

16. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato

17. S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology, 2000, 141: 1317-1324. doi:10.1210/en.141.4.1317.

18. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin Д. Physiological Reviews, 1998, 78: 1193-1231.

19. Jenster G, Spencer TE, Burcin MM, Tsai SY, Tsai MJ, O’Malley BW. Steroid receptor induction of gene transcription: a two-step model. PNAS, 1997, 94: 7879-7884. doi:10.1073/ pnas.94.15.7879.

20. Bouillon R, Carmeliet G, Verlinden L, van Etten

21. E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Reviews, 2008, 29: 726-776. doi:10.1210/er.2008-0004.

22. Agic A, Xu H, Altgassen C, Noack F, Wolfl er MM, Diedrich K, Frie-drich M, Taylor RN, Hornung D. Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1a-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxy-lase in endometriosis and gynecologic cancers. Reproductive Sciences, 2007, 14: 486-497. doi:10.1177/1933719107304565.

23. Parikh G, Varadinova M, Suwandhi P, Araki T, Rosenwaks Z, Poretsky L, Seto-Young D. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Hormone and Metabolic Research, 2010, 42: 754-757. doi:10.1055/s-0030-1262837.

24. Tanamura A, Nomura S, Kurauchi O, Furui T, Mizutani S, Tomoda Y. Purifi cation and characterization of 1,25(OH)2D3 receptor from human placenta. Journal of Obstetrics and Gynaecology, 1995, 21: 631-639.

25. Henry HL, Norman AW. Vitamin D: metabolism and biological actions. Annual Review of Nutrition, 1984, 4: 493-520. doi:10. 1146/annurev. nu.04.070184.002425.

26. Perez-Fernandez R, Alonso M, Segura C, Munoz I, Garcfa-Caballero T, Дiguez C. Vitamin D receptor gene expression in human pituitary gland. Life Sciences, 1997, 60: 35-42. doi:10. 1016/S0024-3205(96)00586-3.

27. Vigano P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, Panina-Bordignon P, Be-sozzi M, Di Blasio AM. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. Journal of Molecular Endocrinology, 2006, 36: 415-424. doi:10.1677/ jme.1.01946.

28. Sun T, Zhao Y, Mangelsdorf DJ, Simpson ER. Characterization of a region upstream of exon I.1 of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells. Endocrinology, 1998, 139: 1684-1691. doi:10. 1210/en.139.4.1684.

29. Barrera D, Avila E, Hernandez G, Mendez I, Gonzalez L, Halhali A, Larrea F, Morales A, Diaz L. Calcitriol aff ects hCG gene transcription in cultured human syncytiotrophoblasts. Reproductive Biology and Endocrinology, 2008, 6: 3. doi:10.1186/1477-7827-6-3.

30. Barrera D, Avila E, Hernandez G, Halhali A, Biruete B, Larrea F, Diaz L. Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol. Journal of Steroid Biochemistry

31. and Molecular Biology, 2007 103 529-532. doi:10.1016/j.jsbmb.2006.12.097.

32. Tuan RS, Moore CJ, Brittingham JW, Kirwin JJ, Akins RE, Wong M. In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. Journal of Cell Science, 1991, 98: 333-342.

33. Stephanou A, Ross R, Handwerger S. Regulation of human placental lactogen expression by 1,25-dihydroxyvitamin D3. Endocrinology, 1994, 135: 2651-2656. doi:10.1210/en.135.6. 2651.

34. Du H, Daftary GS, Lalwani SI, Taylor HS. Дirect regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Molecular Endocrinology, 2005, 19: 2222-2233. doi:10.1210/me.2004-0336.

35. Bagot CN, Troy PJ, Taylor HS. Alteration of maternal Hoxa10 expression by in vivo gene transfection aff ects implantation. Gene Therapy, 2000, 7: 1378-1384. doi:10.1038/sj.gt.3301245.

36. Hamden K, Carreau S, Jamoussi K, Ayadi F, Garmazi F, Mezgenni N, Elfeki A. Inhibitory effects of 1α, 25dihydroxyvitamin D3 and Ajugaiva extract on oxidative stress, toxicity and hypofertility in diabetic rat testes. Journal of Physiology and Biochemistry, 2008, 64: 231-239. doi:10.1007/BF03216108.

37. Kwiecinski GG, Petrie GI, DeLuca HF. 1,25-Дihydroxyvitamin D3 restores fertility of vitamin D-defi cient female rats. American Journal of Physiology, 1989, 256: E483-E487.

38. Kwiecinski GG, Petrie GI, DeLuca HF. Vitamin D is necessary for reproductive functions of the male rat. Journal of Nutrition, 1989, 119: 741-744.

39. Osmundsen BC, Huang HF, Anderson MB, Christakos S, Walters MR. Multiple sites of action of the vitamin D endocrine system: FSH stimulation of testis 1,25-dihydroxyvitamin

40. D3 receptors. Journal of Steroid Biochemis

41. try, 1989, 34: 339-343. doi:10.1016/0022-4731(89)90105-2.

42. Uhland AM, Kwiecinski GG, DeLuca HF. Normalization of serum calcium restores fertility in vitamin D-defi cient male rats. Journal of Nutrition, 1992, 122: 1338-1344.

43. De Felici M, Dolci S, Siracusa G. An increase of intracellular free Ca2 + is essential for spontaneous meiotic resumption by mouse oocytes. Journal of Experimental Zoology, 1991, 260: 401-405. doi:10.1002/jez.1402600314.

44. Halhali A, Acker GM, Garabedian M. 1,25-Дihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells. Journal of Reproduction and Fertility, 1991, 91: 59-64. doi:10. 1530/jrf.0.0910059.

45. Horii I, Takizawa S, Fujii T. Eff ect of 1,25-dihydroxyvitamin D3 on the female reproductive system in rats. Journal of Toxicological Sciences, 1992, 17: 91-105. doi:10.2131/jts.17.91.

46. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchiyama Y, Masushige S, Fukamizu A, Matsumoto T, Kato S. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nature Genetics, 1997, 16: 391-396. doi:10.1038/ ng0897-391.

47. Kovacs CS, Woodland ML, Fudge NJ, Friel JK. The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice. American Journal of Physiology. Endocrinology and Metabolism, 2005, 289: E133-E144. doi:10.1152/ ajpendo.00354.2004.

48. Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D. Targeted ablation of the 25-hydroxyvitamin D 1α- hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. PNAS, 2001, 98: 7498-7503. doi:10. 1073/pnas.131029498.

49. Johnson LE, DeLuca HF. Vitamin D receptor null mutant mice fed high levels of calcium are fertile. Journal of Nutrition, 2001, 131: 1787-1791.

50. Sun W, Xie H, Ji J, Zhou X, Goltzman D, Miao D. Defective female reproductive function in 1,25(OH)2D-defi cient mice results from indirect eff ect mediated by extracellular calcium and/or phosphorus. American Journal of Physiology. Endocrinology and Metabolism, 2010, 299: E928-E935. doi:10.1152/ajpendo. 00378.2010.

51. Rojansky N, Brzezinski A, Schenker JG. Seasonality in human reproduction: an update. Human Reproduction, 1992, 7: 735-745.

52. Rojansky N, Benshushan A, Meirsdorf S, Lewin

53. A, Laufer N, Safran A. Seasonal variability in fertilization and embryo quality rates in women undergoing IVF. Fertility and Sterility, 2000, 746 476-481. doi:10.1016/S0015-0282(00)00669-5.

54. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian

55. G, Hickmon C, Pal L. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertility and Sterility, 2009, 94: 1314-1319. doi:10.1016/j.fertnstert.2009.05.019.

56. Aleyasin A, Hosseini MA, Mahdavi A, Safdarian L, Fallahi P, Mohajeri MR, Abbasi M, Esfahani F. Predictive value of the level of vitamin D in follicular fl uid on the outcome of assisted reproductive technology. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 2011, 159: 132-137. doi:10.1016/j. ejogrb.2011.07.006.

57. Anifandis GM, Dafopoulos K, Messini CI, Chalvatzas N, Liakos N, Pournaras S, Messinis IE. Prognostic value of follicular fl uid 25-OH vitamin D and glucose levels in the IVF outcome. Reproductive Biology and Endocrinology, 2010, 8: 91. doi:10. 1186/1477-7827-8-91.

58. Asuncion M, Calvo RM, San Millan JL, Sancho

59. J, Avila S, Escobar-Morreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. Journal of Clinical Endocrinology and Metabolism, 2000, 85: 2434-2438. doi:10.1210/ jc.85.7.2434.

60. Diamanti-Kandarakis E, Kouli CR, Bergiele AT, Filandra FA, Tsianateli TC, Spina GG, Zapanti ED, Bartzis MI. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profi le. Journal of Clinical Endocrinology and Metabolism, 1999, 84: 4006-4011. doi:10.1210/jc.84.11. 4006.

61. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews, 1997, 18: 774-800. doi:10.1210/er.18.6.774.

62. Wehr E, Moller R, Horejsi R, Giuliani A, Kopera Д, Schweighofer N, Groselj-Strele A, Pieber TR, Obermayer-Pietsch B. Subcutaneous adipose tissue topography and metabolic disturbances in polycystic ovary syndrome. Wiener Klinische Wochenschrift, 2009, 121: 262-269. doi:10.1007/ s00508-009- 1162-2.

63. Ehrmann ДA. Polycystic ovary syndrome. New England Journal of Medicine, 2005, 352: 1223-1236. doi:10.1056/NEJMra041536.

64. Wehr E, Pilz S, Schweighofer N, Giuliani A, Kopera Д, Pieber TR, Obermayer-Pietsch B. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. European Journal of Endocrinology, 2009, 161: 575-582. doi:10.1530/ EJE-09-0432.

65. Ngo DT, Chan WP, Rajendran S, Heresztyn T, Amarasekera A, Sverdlov AL, O’Loughlin PД, Morris HA, Chirkov YY, Norman RJ, Horowitz JD. Determinants of insulin responsiveness in young women: impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide, 2011, 25: 326-330. doi:10.1016/j.niox. 2011.06.005.

66. Yildizhan R, Kurdoglu M, Adali E, Kolusari A, Yildizhan B, Sahin HG, Kamaci M. Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Archives of Gynecology and Obstetrics, 2009, 280: 559-563. doi:10.1007/s00404-009-0958-7.

67. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, Kimmig R, Mann K, Janssen OE. Low serum 25-hydroxyvitamin

68. D concentrations are associated with insulin resistance and obesity in women with polycys-tic ovary syndrome. Experimental and Clinical Endocrinology and Diabetes, 2006, 114: 577-583. doi:10.1055/s-2006-948308.

69. Mahmoudi T, Gourabi H, Ashrafi M, Yazdi RS, Ezabadi Z. Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome. Fertility and Sterility, 2010, 93: 1208-1214. doi:10.1016/j. fertnstert.2008.11.031.

70. Li HW, Brereton RE, Anderson RA, Wallace AM, Ho CK. Vitamin D defi ciency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism, 2011, 60: 1475-1481. doi:10.1016/j.metabol. 2011.03.002.

71. Panidis D, Balaris C, Farmakiotis Д, Rousso Д, Kourtis A, Balaris V, Katsikis I, Zournatzi V, Diamanti-Kandarakis E. Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clinical Chemistry, 2005, 51: 1691-1697. doi:10.13 73/ clinchem.2005.052761.

72. Chavarro JE, Rich-Edwards JW, Rosner B, Willett WC. A prospective study of dairy foods intake and anovulatory infertility. Human Reproduction, 2007, 22: 1340-1347. doi:10.1093/ humrep/ dem019.

73. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. American Journal of Clinical Nutrition, 2000, 72: 690-693.

74. Compston JE, Vedi S, Ledger JE, Webb A, Gazet JC, Pilkington TR. Vitamin D status and bone histomorphometry in gross obesity. American Journal of Clinical Nutrition, 1981, 34: 2359-2363.

75. Kamycheva E, Joakimsen RM. Jorde R. Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. Journal of Nutrition, 2003, 133: 102-106.

76. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin Д and calcium in type 2 diabetes. A systematic review and meta-analysis. Journal of Clinical Endocrinology and Metabolism, 2007, 92: 2017-2029. doi:10.1210/jc.2007-0298.

77. Maestro B, Davila N, Carranza MC, Calle C. Identi-

78. fi cation of a vitamin D response element in the human insulin receptor gene promoter. Journal of Steroid Biochemistry and Molecular Biology, 2003, 84: 223-230. doi:10.1016/S0960-0760(03)00032-3.

79. Maestro B, Molero S, Bajo S, Davila N, Calle C. Transcriptional activation of the human insulin receptor gene by 1,25- dihydroxyvitamin D (3). Cell Biochemistry and Function, 2002, 20: 227-232. doi:10.1002/cbf.951.

80. Milner RD, Hales CN. The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia, 1967, 3: 47-49. doi:10.1007/BF01269910.

81. Bikle D. Nonclassic actions of vitamin D. Journal of Clinical Endocrinology and Metabolism, 2009, 94: 26-34. doi:10.1210/jc. 2008-1454.

82. Shoelson SE, Herrero L, Naaz A. Obesity, infl am-mation, and insulin resistance. Gastroenterology, 2007, 132: 2169-2180. doi:10.1053/j.gastro.2007.03.059.

83. Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba AJ. Eff ects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment. Journal of Clinical Endocrinology and Metabolism, 2011, 96: 3494-3501. doi:10.1210/ jc.2011-0501.

84. Sathyapalan T, Shepherd J, Arnett C, Coady AM, Kilpatrick ES, Atkin SL. Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome. Clinical Chemistry, 2010, 56: 1696-1700. doi:10.1373/ clinchem.2010. 144014.

85. Mahmoudi T. Genetic variation in the vitamin Д receptor and polycystic ovary syndrome risk. Fertility and Sterility, 2009, 92: 1381-1383. doi:10.1016/j.fertnstert.2009.05.002.

86. Wehr E, Trummer O, Giuliani A, Gruber HJ, Pieber TR, Obermayer-Pietsch B. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D defi ciency in polycystic ovary syndrome. European Journal of Endocrinology, 2011, 164: 741-749. doi:10.1530/EJE-11-0134.

87. Ranjzad F, Mahban A, Shemirani AI, Mahmoudi T, Vahedi M, Nikzamir A, Zali MR. Infl uence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. Journal of Assisted Reproduction and Genetics, 2011, 28: 225-232. doi:10.1007/ s10815-010-9506-4.

88. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel ДP, Streeten EA, Ohls-son C, Koller ДL, Peltonen L, Cooper JД, O’Reilly PF, Houston ДK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH. Common genetic determinants of vitamin D insuffi ciency: a genome-wide association study. Lancet, 2010, 376: 180-188. doi:10.1016/ S0140-6736(10)60588-0.

89. Thys-Jacobs S, Дonovan Д, Papadopoulos A, Sar-rel P, Bilezikian JP. Vitamin D and calcium dys-regulation in the polycystic ovarian syndrome. Steroids, 1999, 64: 430-435. doi:10.1016/S0039-128X(99)00012-4.

90. Selimoglu H, Duran C, Kiyici S, Ersoy C, Guclu M, Ozkaya G, Tuncel E, Erturk E, Imamoglu S. The effect of vitamin Dreplacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. Journal of Endocrino-logical Investigation, 2010, 33: 234-238.

91. Kotsa K, Yavropoulou MP, Anastasiou O, Yovos JG. Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertility and Sterility, 2009, 92: 1053-1058. doi:10. 1016/j. fertnstert.2008.07.1757.

92. Wehr E, Pieber TR, Obermayer-Pietsch B. Eff ect of vitamin D3 treatment on glucose metabolism and menstrual frequency in PCOS women - a pilot study. Journal of Endocrinological Investigation, 2011, 34: 757-763. doi:10.3275/7748.

93. Rashidi B, Haghollahi F, Shariat M, Zayerii F. The eff ects of calcium-vitamin Д and metformin on polycystic ovary syndrome: a pilot study. Taiwanese Journal of Obstetrics and Gynecology, 2009, 48: 142-147. doi:10.1016/S1028-4559(09)60275-8.

94. Knight JA, Wong J, Blackmore KM, Raboud JM, Vieth R. Vitamin D association with estradiol and progesterone in young women. Cancer Causes and Control, 2010, 21: 479-483. doi:10. 1007/s10552-009-9466-0.

95. Freedman DM, Looker AC, Chang SC, Graubard BI. Prospective study of serum vitamin D and cancer mortality in the United States. Journal of the National Cancer Institute, 2007, 99: 1594-1602. doi:10.1093/jnci/djm204.

96. Somigliana E, Panina-Bordignon P, Murone S, Di Lucia P, Vercellini P, Vigano P. Vitamin D reserve is higher in women with endometriosis. Human Reproduction, 2007, 22: 2273-2278. doi:10.1093/ humrep/dem142.

97. Hartwell D, R0dbro P, Jensen SB, Thomsen K, Christiansen C. Vitamin D metabolites - relation to age, menopause and endometriosis. Scandinavian Journal of Clinical and Laboratory Investigation, 1990, 50: 115-121. doi:10.3109/003655190090 89142.

98. Vilarino FL, Bianco B, Lerner TG, Teles JS, Mafra FA, Christofolini DM, Barbosa CP. Analysis of vitamin D receptor gene polymorphisms in women with and without endometriosis. Human Immunology, 2011, 72: 359-363. doi:10.1016/j. humimm.2011.01.006.

99. Faserl K, Golderer G, Kremser L, Lindner H, Sarg B, Wildt L, Seeber B. Polymorphism in vitamin D-binding protein as a genetic risk factor in the pathogenesis of endometriosis. Journal of Clinical Endocrinology and Metabolism, 2011, 96: E233-E241.doi:10.1210/jc.2010-1532.

100. Borkowski J, Gmyrek GB, Madej JP, Nowacki W, Goluda M, Gabrys M, Stefaniak T, Chelmomka-Soyta A. Serum and peritoneal evaluation of vitamin D-binding protein in women with endometriosis. Postepy Higieny i Medycyny Дdoswiadczalnej, 2008, 62: 103-111.

101. Ferrero S, Gillott ДJ, Anserini P, Remorgida V, Price KM, Ragni N, Grudzinskas JG. Vitamin D binding protein in endometriosis. Journal of the Society of Gynecological Investigation, 2005, 12: 272-277. doi:10.1016/j.jsgi.2005.01.02 7.

102. Dent CE, Gupta MM. Plasma 25-hydroxyvitamin-D-levels during pregnancy in Caucasians and in vegetarian and nonvegetarian Asians. Lancet, 1975, 2: 1057-1060. doi:10.1016/ S0140-6736(75)90430-4.

103. Turton CW, Stanley P, Stamp TC, Maxwell JД. Altered vitamin-D metabolism in pregnancy. Lancet, 1977 1 222-225. doi:10. 1016/S0140-6736(77)91017-0.

104. Looker AC, Pfeiff er CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. American Journal of Clinical Nutrition, 2008, 88: 1519-1527. doi:10.3945/ ajcn.2008.26182.

105. Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, Williams MA. Maternal plasma 25-hydroxyvitamin Д concentrations and the risk for gestational diabetes mellitus. PLoS ONE, 2008, 3(11): e3753. doi:10.1371/journal.pone.0003753.

106. Maghbooli Z, Hossein-Nezhad A, Karimi F, Shafaei AR, Larij ani B. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metabolism Research and Review, 2008, 24: 27-32. doi:10.1002/dmrr.737.

107. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D defi -ciency increases the risk of preeclampsia. Journal of Clinical Endocrinology and Metabolism, 2007, 92: 3517-3522. doi:10.1210/jc.2007-0718.

108. Bodnar LM, Krohn MA, Simhan HN. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. Journal of Nutrition, 2009, 139: 1157-1161. doi:10.3945/jn.108.103168.

109. Haugen M, Brantsaeter AL, Trogstad L, Alexander J, Roth C, Magnus P, Meltzer HM. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology, 2009 Sep, 20(5):720-6. doi: 10.1097/ EDE.0b013e3181a70f08.

110. Bodnar LM, Catov JM, Zmuda JM, Cooper ME, Parrott MS, Roberts JM, Marazita ML, Simhan HN. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for gestational age births in white women. Journal of Nutrition, 2010, 140: 999-1006. doi:10.3945/ jn.109.119636.

111. Brooke OG, Brown IR, Bone CD, Carter ND, Cleeve HJ, Maxwell JD, Robinson VP, Winder SM. Vitamin D supplements in pregnant Asian women: eff ects on calcium status and fetal growth. BMJ, 1980, 280: 751-754. doi:10.1136/ bmj.280.6216.751.

112. Wagner CL, Greer FR & American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and vitamin D defi ciency in infants, children, and adolescents. Pediatrics, 2008, 122: 1142-1152. doi:10.1542 / peds.2008- 1862.

113. Javaid MK, Crozier SR, Harvey NC, Gale CR, Den-nison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C. Princess Anne Hospital Study Group. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet, 2006, 367: 36-43. doi:10.1016/ S0140-6736(06)67922-1.

114. Camargo CA Jr, Rifas-Shiman SL, Litonjua AA, Rich-Edwards JW, Weiss ST, Gold DR, Kleinman K, Gillman MW. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. American Journal of Clinical Nutrition, 2007, 85: 788-795.

115. McGrath J. Does ‘imprinting’ with low prenatal vitamin D contribute to the risk of various adult disorders? Medical Hypotheses, 2001, 56: 367-371. doi:10.1054/mehy.2000.1226.

116. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. Journal of Bone and Mineral Research, 2011, 26: 2341-2357. doi:10.1002/ jbmr.463.

117. Hollis BW. Randomized controlled trials to determine the safety of vitamin D supplementation during pregnancy and lactation. In Fourteenth Workshop on Vitamin D. Brugge, Belgium, 2009.

118. Holick MF, Binkley NC, Bischoff -Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 2011, 96: 1911-1930. doi:10.1210/jc.2011-0385.

119. Heany RP. Vitamin D in health and disease. Clinical Journal of the American Society of Nephrology, 2008, 3: 1535-1541. doi:10. 2215/ CJN.01160308.

120. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporosis International, 1997, 7: 439-443. doi:10.1007/s001980050030.

121. Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. European Journal of Endocrinology, 2012, 166: 765–778.


Просмотров: 172


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)