Practical use of modern guidelines for the diagnosis and treatment of exocrine pancreatic insufficiency in patients with chronic pancreatitis
https://doi.org/10.21518/2079-701X-2018-14-109-113
Abstract
The article presents a review of current European and Russian guidelines on diagnostics and treatment of exocrine pancreatic insufficiency in patients with chronic pancreatitis. Results of our own comparative study on treatment of 55 chronic pancreatitis patients with low and adequate doses of pancreatic enzyme replacement therapy (PERT) confirm the need for usage of recommended doses of modern micronized polyenzyme drugs since it improves both clinical manifestation and nutritional status in such patients unlike the lower doses. Our research findings show that the optimal criterium for PERT efficacy assessment is the normalization of antropometric and biochemical nutritional markers.
About the Authors
O. N. Minushkin
Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian Federation
Russian Federation
Russian Federation
L. V. Maslovsky
Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian Federation
Russian Federation
Russian Federation
A. E. Evsikov
Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian Federation
Russian Federation
Russian Federation
A. M. Chebotareva
Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian Federation
Russian Federation
Russian Federation
References
1. Khatkov IE, Maev IV, Bordin DS, et al. Russian consensus on the diagnosis and treatment of chronic pancreatitis. Ter. Arkhiv, 2017, 2: 105-113.
2. Matthias Lоhr J, Dominguez-Munoz JЕ, Rosendah J et al. United European Gastroenterology evidence based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU) United European. Gastroenterology Journal, 2017, 5(2): 153-199.
3. Lindkvist B, Phillips ME, Dominguez-Munoz JE. Clinical, anthropometric and laboratory nutritional markers of pancreatic exocrine insufficiency: Prevalence and diagnostic use. Pancreatology, 2015, 15: 589-397.
Review
For citations:
Minushkin ON, Maslovsky LV, Evsikov AE, Chebotareva AM. Practical use of modern guidelines for the diagnosis and treatment of exocrine pancreatic insufficiency in patients with chronic pancreatitis. Meditsinskiy sovet = Medical Council. 2018;(14):109-113. (In Russ.) https://doi.org/10.21518/2079-701X-2018-14-109-113
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