Пазопаниб в терапии распространенного почечноклеточного рака

Пазопаниб – пероральный мультикиназный ингибитор, применяемый при распространенном раке почки в большинстве стран мира. Пазопаниб блокирует рецепторы тирозинкиназ, участвующих в опухолевом ангиогенезе и пролиферации, включая VEGF, фактор роста, исходящий из тромбоцитов (PDGF), и фактор роста стволовых клеток c-Kit, что приводит к ингибированию ангиогенеза, роста и пролиферации опухолевых клеток. В клинических испытаниях пазопаниб демонстрировал преимущество в БПВ по сравнению с плацебо у ранее не леченных больных и пациентов, получавших цитокины, а также отсутствие ущерба БПВ по сравнению с сунитинибом в первой линии терапии светлоклеточного ПКР групп хорошего и промежуточного прогноза. Кроме того, пазопаниб продемонстрировал лучший профиль безопасности, чем сунитиниб. Результаты применения пазопаниба в широкой клинической практике согласуются с данными рандомизированных исследований, подтверждая высокую эффективность данного препарата в сочетании с хорошей переносимостью даже у пациентов, не соответствующих общепринятым критериям включения в клинические испытания.

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