Tyrosine kinase inhibitor Tofacitinib. Safety issues
https://doi.org/10.21518/2079-701X-2015-10-77-81
Abstract
Tofacitinib (TOFA) was the first synthetic small molecule drug which was comparable with genetically engineered biological agents (GIBA) in terms of its therapeutic effect in rheumatoid arthritis (RA). Results of treatment of over 4 thousand RA patients showed that the most common adverse events were nasopharyngitis, upper respiratory infections and urinary tract infections, herpes, diarrhea, nausea, gastritis. Serious side effects were registered in 15.4% of patients, and serious infections in 4.5%. Opportunistic infections occurred in 0.6% of patients, half of which were cases of tuberculosis. Anemia, hemocytopenia, increased lipidemia, a mild temporary decrease in glomerular filtration rate and increased creatinemia were also recorded. There were no anaphylactic or other immediate reactions. TOFA administration results were not different from those after treatment with GIBA in terms of mortality, incidence of infections and cancer.
About the Authors
G. V. Lukina
V.A. Nasonova Research Institute of Rheumatology RAMS; Moscow Clinical Research Center
Russian Federation
Russian Federation
Y. A. Sigidin
V.A. Nasonova Research Institute of Rheumatology RAMS
Russian Federation
Russian Federation
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Review
For citations:
Lukina GV, Sigidin YA. Tyrosine kinase inhibitor Tofacitinib. Safety issues. Meditsinskiy sovet = Medical Council. 2015;(10):77-81. (In Russ.) https://doi.org/10.21518/2079-701X-2015-10-77-81
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