Clinical and neurophysiological studies of chronic demyelinating polyneuropathy associated with monoclonal secretion
https://doi.org/10.21518/2079-701X-2015-10-93-99
Abstract
Paraproteinemic polyneuropathy accounts for up to 30% of chronic demyelinating polyneuropathies. The aim of this study was to determine the clinical and neurophysiological patterns of the nosology compared with chronic inflammatory demyelinating polyneuropathy (CIDP). We examined 30 patients with PNP against a background of monoclonal gammopathy (16 with monoclonal gammopathy of undetermined significance (MGUS) and 14 with hemoblastosis) and 30 patients with CIDP. The history, neurological status and results of stimulation electroneuromyography were evaluated. A number of significant differences were recorded which suggest paraproteinemia in patients with demyelinating PNP. Nevertheless, immunofixation electrophoresis is currently the only method of the disease verification.
About the Authors
M. A. Ginsberg
Research Center of Neurology
Russian Federation
Russian Federation
E. Y. Varlamova
Hematological Scientific Centre
Russian Federation
Russian Federation
V. V. Ryzhko
Hematological Scientific Centre MH RF, Moscow
Russian Federation
Russian Federation
N. А. Suponeva
Research Center of Neurology
Russian Federation
Russian Federation
M. A. Piradov
Hematological Scientific Centre
Russian Federation
Russian Federation
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Review
For citations:
Ginsberg MA, Varlamova EY, Ryzhko VV, Suponeva NА, Piradov MA. Clinical and neurophysiological studies of chronic demyelinating polyneuropathy associated with monoclonal secretion. Meditsinskiy sovet = Medical Council. 2015;(10):93-99. (In Russ.) https://doi.org/10.21518/2079-701X-2015-10-93-99
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