Treatment of chronic venous insufficiency of the lower extremities
https://doi.org/10.21518/2079-701X-2019-12-153-158
Abstract
The article discusses up-to-date concepts of the prevalence, pathogenesis and clinical manifestations of chronic venous diseases and chronic venous insufficiency of the lower extremities. It discusses the current views on the mechanism of action of various phlebotrophic drugs used in the symptomatic treatment of chronic venous diseases of the lower extremities and chronic venous insufficiency, updates data on the advantages of micronized purified flavonoid fraction for the treatment of all clinical classes of chronic venous diseases.
About the Author
M. N. Kudykin
Association of Angiologists, Phlebologists and Vascular Surgeons of Nizhny Novgorod Region
Russian Federation
Russian Federation
Kudykin Maxim Nikolaevich - Dr. of Sci. (Med.), Executive Director of the public organization; Vice-President of Association of Phlebologists of Russia.
603141, Nizhny Novgorod, Geologov St., 1, Office 29; tel.: +7(902) 304-75-75
References
1. Shlyakova A.A., Korneva K.G., Kudykin M.N., Peretyagin P.V. Features of microcirculation of the lower extremities in patients with type 2 diabetes mellitus in combination with chronic venous insufficiency. Terapevt. 2014;1:15-18. (In Russ).
2. Bergan JJ., Schmid-Schonbein G.W., Coleridge-Smith P.D. Chronic venous disease. N Engl J Med. 2006;355(3):488-96.
3. Nicolaides A., Kakkos S., Eklof B., et al. Management of chronic venous disorders of the lower limbs. Guidelines according to scientific evidence. Int Angiol. 2014;33(2):87-208.
4. Allegra C., Antignani P.-L., Bergan J.J., et al. The «С» of CEAP: Suggested definitions and refinements: An international Union of Phlebology conference of experts. J Vasc Surg. 2003;37(1):129-31.
5. Rabe E., Guex J.-J., Puskas A., Scuderi A., Fernandez Ouesada F. The VCP Coordinators Epidemiology of chronic venous disorders in geographically diverse populations: results from the Vein Consult Program. Int Angiol. 2012;31(2):105-15.
6. Eklof Bo, Perrin M., Konstantinos T. Delis et al. Up-date terminology of chronic venous disorders: The VEIN-TERM transatlantic interdisciplinary consensus document. J Vasc Surg. 2009;49:498-501.
7. Bogachev V.Yu. Modern pharmacotherapy of chronic venous insufficiency of the lower extremities. Farmat-sevtichesky Vestnik. 2006;10(2):54-59. (In Russ).
8. Ruckley C.V., Fowkes F.G.R., Bradbury A.W. VenousDisease. Epidemiology, Management and Delivery of Care.Springer.1999; 278.
9. Jawien A., Grzela T., Ochwat A. Prevalence of chronic venous insufficiency in men and women in Poland: multicentre cross-sectional study in 40095 patients. Phlebology. 2003;81:110-122.
10. Langer R.D., Ho E., Deneberg J.O., et al. Relation-ship between symptoms and venous disease. Arch Int Med. 2005;165:1420-1424.
11. Labropoulos N., Stansby G. Venous and Lymphatic Diseases. Taylor & Francis. 2006; 559.
12. Schmid-Schonbein G.W., Granger D.N. Molecular Basis for Microcirculatory Disorders. Springer. 2003; 640.
13. Nicolaides A.N., Allegra C., Bergan J. et al. Management of Chronic Venous Disorders of the Lower Limbs Guidelines According to Scientific Evidence. International Angiology. 2008;27:1-59.
14. Ramelet A.-A., Perrin M., Kern P., Bounameaux H. Phlebology, 5-th edition, Elsevier Masson. 2008:565.
15. Davies A.H. Management of Chronic Venous Disease: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg. 2015 Nov 17. pii: S1078-5884(15)00699-1. doi: 10.1016/j.ejvs.2015.09.024.
16. Varicose Veins in the Legs: The Diagnosis and Management of Varicose Veins. National Clinical Guideline Centre (UK). London: National Institute for Health and Care Excellence (UK); 2013 Jul.
17. Russian clinical guidelines for diagnosis and treatment of chronic venous diseases. Flebologia. 2018;3:146-240 (In Russ).
18. das Gragas C., de Souza M., Cyrino F.Z., de Carvalho JJ. Protective Effects of Micronized Purified Flavonoid Fraction (MPFF) on a Novel Experimental Model of Chronic Venous Hypertension. Eur J Vasc Endovasc Surg. 2018 May;55(5):694-702. doi: 10.1016/j.ejvs.2018.02.009. Epub 2018 Mar 24.
19. Jantet G. RELIEF Study Group. Chronic Venous Insufficiency: Worlwide Results of the RELIEF Study. Angiology. 2002;53:245-256.
20. Rabe E., Agus G.B., Roztocil K. Analysis of the effects of micronized purified flavonoid fraction versus placebo on symptoms and quality of life in patients suffering from chronic venous disease: from a prospective randomized trial. Int Angiol. 2015 Oct;34(5):428-36. Epub 2015 May 14.
21. Belczak S.Q., Sincos I.R., Campos W., Beserra J., Nering G., Aun R. Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial. Phlebology. 2014 Aug;29(7):454-60. doi: 10.1177/0268355513489550. Epub 2013 May 16.
22. Maggioli A., Carpentier P. Efficacy of MPFF 1000 mg oral suspension on CVD C0s-C1- related symptoms and quality of life. Int Angiol. 27. 2019 Apr;38(2):83-89. doi: 10.23736/S0392-9590.18.04054-3.
23. StoTko I.M., Iashkin M.N., Tiurin V.P., Gudymovich V.G. Efficacy and safety of micronized purified flavonoid fraction (MPFF) in treatment of venousdiseases in geriatric patients. Angiol Sosud Khir. 2019;25(1):88-91.
24. Bogachev V.Y., Boldin B.V., Lobanov V.N. Benefits of micronized purified flavonoid fraction as adjuvant therapy on inflammatory response after sclerotherapy. Int Angiol. 2018 Feb;37(1):71-78. doi: 10.23736/S0392-9590.17.03868-8. Epub 2017 Sep 22.
25. Colerige-Smith P, Lok C., Ramelet A.A. Venous leg ulcer: meta-analysis of adjunctive therapy with micronized purified flavonoid fraction. Eur J Vasc. Endovasc. Surg. 2005;30:198-208.
26. Chesnokova N.N., Kononova S.V., Zaporozhskaya L.I., Kudykin M.N. Study of the regional market segment of drugs to treat and prevent varicose veins of the lower extremities. MeditsynskyAlmanakh. 2015;4(39):205-209. (In Russ).
27. Porembskaya O.Ya., Kosenko I.M. Pharmacotherapy for chronic vein diseases: how to choose efficiently a phlebotropic drug? Flebologia. 2018;12(3):123-133. https://doi.org/10.17116/flebo201812312. (In Russ).
28. http://www.gks.ru/wps/wcm/connect/rosstat_main/rosstat/ru/statistics/population/level/section: Incomes, expenses and living conditions of households (In Russ).
Review
For citations:
Kudykin MN. Treatment of chronic venous insufficiency of the lower extremities. Meditsinskiy sovet = Medical Council. 2019;(12):153-158. (In Russ.) https://doi.org/10.21518/2079-701X-2019-12-153-158
Views:
902
Email this article 