Modern prospects for treating genital herpes
https://doi.org/10.21518/2079-701X-2019-13-80-84
Abstract
The review focuses on the clinical and epidemiological characteristics of herpes viral infection, in particular genital herpes. The current treatment options for recurrent genital herpes are presented. The main mechanisms of action of acyclic nucleosides are presented. A detailed description of valaciclovir (Valvir) is given.
About the Authors
A. A. KhryaninRussian Federation
Khryanin Aleksey Alekseevich, Dr. of Sci. (Med.), Professor, Chair for Dermatovenerology and Cosmetology, Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian Federation
Novosibirsk; Krasnyy Prospekt, 52, Novosibirsk, 630091,
Lenina ul., 55, Novosibirsk, 630108
О. V. Reshetnikov
Russian Federation
Reshetnikov Oleg Vadimovich, Dr. of Sci. (Med.), Leading Researcher
Novosibirsk; Borisa Bogatkova ul., 175/1, Novosibirsk, 630089
References
1. Looker K.J., Garnett G.P., Schmid G.P. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ. 2008t;86(10):805-812. doi: 10.2471/blt.07.046128.
2. Khryanin A.A., Reshetnikov O.V., Kandrushina M.P. Long-term trends in the prevalence rate of the herpes simplex virus in the siberian population. Vestnik Dermatologii i Venerologii. 2010;(5):96-101. (In Russ.) Available at: https://elibrary.ru/item.asp?id=15318354.
3. Centers for Disease Control and Prevention. Guidelines for treatment of sexually transmitted diseases. MMWR. 2015. Available at: https://www.cdc.gov/std/tg2015/tg-2015-print.pdf.
4. Goryachkina M.V., Belousova T.A. Episodic and suppressive therapy of herpes simplex using acyclic nucleosides. Klinicheskaya dermatologiya i venerologiya = Russian Journal of Clinical Dermatology and Venereology. 2014;(4):68-74. (In Russ.) Available at: https://www.mediasphera.ru/issues/klinicheskaya-dermatologiya-i-venerologiya/2014/4/031997-28492014413.
5. Orlov E.V., Kotel’nikova E.V., Vasil’yev-Stupal’skiy E.A., Mudarisov R.M., Pevzner N.J. Genital herpes: efficacy of antiviral therapy. Klinicheskaya dermatologiya i venerologiya = Russian Journal of Clinical Dermatology and Venereology. 2015;(3):40-45. (In Russ.) doi: 10.17116/klinderma20151434045.
6. Khaldin A.A., Giliadov A.D., Bykhanova O.N., Isaeva D.R. Generic synthetic acyclic nucleosides in causal treatment of herpes simplex relapses. Klinicheskaya dermatologiya i venerologiya = Russian Journal of Clinical Dermatology and Venereology. 2014;(2):79-83. Available at: https://www.mediasphera.ru/issues/klinicheskayadermatologiya-i-venerologiya/2014/2/031997-28492014214/annotation.
7. Clinical guidelines for the management of patients with sexually transmitted infections and urogenital infections. Russian Society of Dermatovenerologists and Cosmetologists. 2012. (In Russ). Available at: https://www.dnatechnology.ru/sites/default/files/klinicheskie_rekomendacii_zppp.pdf.
8. Ipsos Comcon, survey Prindex «Drug Prescription Monitoring», Autumn Wave, 2018. (In Russ.) Available at: https://www.ipsos.com/ru-kz/rynok-naznacheniy-lekarstvennykh-preparatovitogi-2018-goda.
9. Canadian Agency for Drugs and Technologies in Health. Acyclovir versus valacyclovir for herpes virus in children and pregnant women: a review of the clinical evidence and guidelines. CADT Rapid Response Reports. 2014. Available at: https://www.ncbi.nlm.nih.gov/pubmed/25411683.
10. Hollier L.M., Wendel G.D. Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal herpes. Cochrane Database Syst Rev. 2008;(1):CD004946. doi: 10.1002/14651858.CD004946.pub2.
Review
For citations:
Khryanin AA, Reshetnikov ОV. Modern prospects for treating genital herpes. Meditsinskiy sovet = Medical Council. 2019;(13):80-84. (In Russ.) https://doi.org/10.21518/2079-701X-2019-13-80-84