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Фармакогенетика ингибиторов протонной помпы

https://doi.org/10.21518/2079-701X-2015-17-96-103

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Аннотация

Ингибиторы протонной помпы (ИПП) в настоящее время являются наиболее эффективным классом антисекреторных препаратов и широко применяются в лечении неязвенной диспепсии, рефлюкс-эзофагита и ГЭРБ, язвенной болезни и H. pilory-инфекции, а также НПВП-ассоциированных поражений желудка. Несмотря на общий механизм действия и фармакологические эффекты препаратов данного класса, в клинической практике наблюдается межиндивидуальная вариабельность влияния на продукцию кислоты, зависящая от фармакокинетических и фармакогенетических факторов. В результате наблюдается снижение клинической эффективности лечения кислотозависимых заболеваний и эрадикационной терапии против H. pilory.

Об авторе

М. В. Леонова
Российский национальный исследовательский медицинский университет им. Н.И. Пирогова
Россия


Список литературы

1. MaLfertheiner P, Megraud F, O'Morain CA et al. Management of Helicobacter pylori infection-the Maastricht IV/Florence Consensus Report. Gut, 2012. 61: 646-64.

2. Kuo CH, Kuo FC, Hu HM et al. The optimal first-line therapy of Helicobacter pylori infection in year 2012. Gastroenterol Res Pract, 2012. Article ID 168361, 8 pages. doi:10.1155/2012/168361

3. Graham DY, Shiotani A. New Concepts of Resistance in the Treatment of Helicobacter pylori Infections. Nat Clin Pract Gastroenterol Hepatol, 2008. 5(6): 321-31.

4. Kusano M, Kuribayashi S, Kawamura O et al. A Review of the management of gastric acid-related diseases: focus on rabeprazole. Clinical Medicine Insights: Gastroenterology, 2011. 3: 31-43.

5. Kirchheiner J, Glatt S, Fuhr U et al. Relative potency of proton-pump inhibitors - comparison of effects on intragastric pH. Eur J Clin Pharmacol, 2009. 65: 19-31.

6. Kromer W, Kruger U, Huber R et al. Differences in pH-dependent activation rates of substituted benzimidazoles and biological in vitro correlates. Pharmacology, 1998. 56: 57-70.

7. Pantoflickova D, Dorta G, Ravic M et al. Acid inhibition on the first day of dosing: comparison of four proton pump inhibitors. Aliment Pharmacol Ther, 2003. 17(12): 1507-14.

8. Meyer UA. Metabolic interactions of the protonpump inhibitors lansoprazole, omeprazole and pantoprazole with other drugs. Eur. J. Gastroenterol. Hepatol, 1996. 8 (Suppl. 1): S21-S25.

9. Sugimoto M, Furuta T. Efficacy of tailored Helicobacter pylori eradication therapy based on antibiotic susceptibility and CYP2C19 genotype. World J. Gastroenterol, 2014. 20: 6400-11.

10. Robinson M, Horn J. Clinical pharmacology of proton pump inhibitors: what the practising physician needs to know. Drugs, 2003. 63(24): 2739-54.

11. Horn J. Review article: relationship between the metabolism and efficacy of proton pump inhibitors - focus on rabeprazole. Aliment. Pharmacol. Ther., 2004. 20(Suppl. 6): 11-9.

12. Klotz U, Schwab M, Treiber G. CYP2C19 polymorphism and proton pump inhibitors. Basic Clin. Pharmacol. Toxicol., 2004. 95: 2-8.

13. Kuo CH, Lu CY, Shih HY. CYP2C19 polymorphism influences Helicobacter pylori eradication. World J Gastroenterol, 2014. 20(43): 16029-36.

14. Sahara S, Sugimoto M, Uotani T et al. Twice-daily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolis-ers compared with twice-daily omeprazole, rabeprazole or lansoprazole. Aliment Pharmacol Ther, 2013. 38: 1129-37.

15. Hu YM, Xu JM, Mei О et al. Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotype in healthy Chinese subjects. Acta Pharmacologica Sinica, 2005. 26 (3): 384-8.

16. Sim SC, Risinger C, Dahl M-L et al. A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin Pharmacol Ther, 2006. 79: 103-13.

17. Li-Wan-Po A, Girard T, Farndon P et al. Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17. Br J Clin Pharmacol, 2010. 69 (3):222-30.

18. Sugimoto M, Shirai N, Nishino M et al. Rabeprazole 10 mg q.d.s. decreases 24-h intra-gastric acidity significantly more than rabepra-zole 20 mg b.d. or 40 mg o.m., overcoming CYP2C19 genotype. Aliment Pharmacol Ther, 2012. 36: 627-34.

19. Goldstein JA, Ishizaki T, Chiba K et al. Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabo-lizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics, 1997. 7: 59-64.

20. Мирзаев К.Б., Сычев Д.А., Андреев Д.А. Этнические особенности в Российской Федерации полиморфизма гена cyp2d9, ассоциированного с нарушением ответа на клопидогрел. Молекулярная медицина, 2014. 1: 13-21.

21. Furuta T, Shirai N, Takashima M et al. Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin. Clin. Pharmacol. Ther., 2001. 69: 158-68.

22. Furuta T, Ohashi K, Kamata T et al. Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann. Intern. Med, 1998. 129: 1027-30.

23. Chaudhry AS, Kochhar R, Kohli KK. Genetic polymorphism of CYP2C19 & therapeutic response to proton pump inhibitors. Indian J Med Res, 2008. 127: 521-30.

24. Padol S, Yuan Y, Thabane M et al. The effect of CYP2C19 polymorphisms on H. pylori eradication rate in dual and triple first-line PPI therapies: а meta-analysis. Am. J. Gastroenterol., 2006. 101: 1467-75.

25. Zhao F, Wang J, Yang Y et al. Effect of CYP2C19 genetic polymorphisms on the efficacy of proton pump inhibitor-based triple therapy for Helicobacter pylori eradication: a meta-analysis. Helicobacter, 2008. 13(6): 532-41.

26. McNicholl AG, Linares PM, Nyssen OP et al. Meta-analysis: еsomeprazole or rabeprazole vs. first-generation pump inhibitors in the treatment of Helicobacter pylori infection. Aliment Pharmacol. Ther., 2012. 36: 414-425.

27. Tamura T, Kurata M, Inoue ES et al. Improvements in Helicobacter pylori eradication rates through clinical CYP2C19 genotyp-ing. Nagoya J. Med. Sci., 2011. 73: 25-31.

28. Furuta T, Shirai N, Kodaira M et al. Pharmaco-genomics-based tailored versus standard therapeutic regimen for eradication of H. pylori. Clin Pharmacol Ther, 2007. 81: 521-8.

29. Furuta T, Shirai N, Sugimoto M et al. Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies. Drug Metab. Pharmacokinet., 2005. 20(3): 153-67.

30. Sugimoto M, Furuta T, Shirai N et al. Comparison of an increased dosage regimen of rabeprazole versus a concomitant dosage regimen of famotidine with rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotypes. Clin. Pharmacol. Ther., 2005.; 77(4): 302-11.

31. Kawamura M, Ohara S, Koike T et al. The effects of lansoprazole on erosive reflux oesophagitis are influenced by CYP2C19 polymorphism. Aliment Pharmacol. Ther., 2003. 17(7): 965-73.

32. Lee YC, Lin JT, Wang HP et al. Influence of cytochrome P450 2C19 genetic polymorphism and dosage of rabeprazole on accuracy of proton-pump inhibitor testing in Chinese patients with gastroesophageal reflux disease. J. Gastroenterol. Hepatol., 2007. 22(8): 1286-92.

33. Thomson AB, Sauve MD, Kasam N, Kamitakahara H. Safety of long-term use of protein pump inhibitors. World J. Gastroenterol, 2010. 16(19): 2323-30.

34. Hu YM, Mei О, Xu XH et al. Pharmacodynamic and kinetic effect of rabeprazole on serum gastrin level in relation to CYP2C19 polymorphism in Chinese. World J Gastroenterol, 2006. 12(29): 4750-3.

35. Furuta T, Sugimoto M, Shirai N. Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromy-cin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. Aliment. Pharmacol. Ther., 2007. 26: 693-703.

36. Hagymasi K, Mullner K, Herszenyi L, Tulassay Z. Update on the Pharmacogenomics of Proton Pump Inhibitors. Pharmacogenomics, 2011. 12(6): 873-88.

37. Lehmann DF, Medicis JJ, Franklin PD. Polymorphisms and the pocketbook: the cost-effectiveness of cytochrome P450 2C19 genotyping in the eradication of Helicobacter pylori infection associated with duodenal ulcer. J Clin Pharmacol, 2003. 43(12): 1316-23.


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ISSN 2079-701X (Print)
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