Pharmacogenetics of proton pump inhibitors
https://doi.org/10.21518/2079-701X-2015-17-96-103
Abstract
Proton pump inhibitors (PPI) are currently the most effective class of antisecretory drugs widely used in the treatment of non-ulcer dyspepsia, reflux esophagitis and GERD, peptic ulcer disease and H. pilory infection, as well as NSAID-associated gastric lesions. Despite the common mechanism of action and pharmacological effects of this class of drugs, there is clinical inter-individual variability of their effect on acid production determined by pharmacokinetic and pharmacogenetic factors. As a result, the clinical efficacy of treatment of acid-base disorders and eradication of H. pilory is decreased.
About the Author
M. V. Leonova
Russian Medical Research University named after N.I. Pirogov
Russian Federation
Russian Federation
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Review
For citations:
Leonova MV. Pharmacogenetics of proton pump inhibitors. Meditsinskiy sovet = Medical Council. 2015;(17):96-103. (In Russ.) https://doi.org/10.21518/2079-701X-2015-17-96-103
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