Effect of a new oral contraceptive on metabolism and the cardiovascular system
https://doi.org/10.21518/2079-701X-2015-XX-10-13
Abstract
The purpose of the study is to assess the impact of drospirenone-containing contraceptives on body weight and blood pressure. Material and methods. The study included 45 women (mean age 26,4 ± 1,32 years). All patients received low-dose combined oral contraceptive (COC) containing 30 mcg Ethinyl Estradiol (EE), 3 mg Drospirenone and 451 mg L-Methylfolate Calcium (Metafolin®) for conraceptive purposes. The contraceptive effect was evaluated by the number of pregnancies in patients receiving COC; side effects were assessed by the renin-aldosterone system function (blood pressure), body weight changes, glucose tolerance (blood glucose and glycated hemoglobin tests) and lipid profile. Study results. The effectiveness of birth control was 100%, without any significant side effects. Conclusion. Low-dose medication Yarina® Plus containing 30 mg micronized EE as betadex clathrate, 3 mg micronized Drospirenone and 451 mg L-Methylfolate Calcium (Metafolin®), in 21/7 regimen, has a high contraceptive efficacy, reduces blood pressure within reference values, regulates body weight and maintains normal levels of lipid and carbohydrate metabolism.
About the Author
E. V. Yenkova
Institute for Supplementary and Professional Education, Voronezh State Medical Academy named after N.N. Burdenko, the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
References
1. Андреева Е.Н. и др. Новые возможности гестагенов: дроспиренон - прогестаген с антиминералкортикоидными свойствами. Российский вестник акушера-гинеколога, 2004, 6.
2. Межевитинова Е.А., Прилепская В.Н. Предменструальный синдром. Гинекология, 2002 (прил.): 3-8.
3. OeLkers W. Drospirenone, a progestogen with antimineralocorticoid properties: a short review. Mol Cell Endocrinol., 2004, Mar. 31, 217(1-2): 255-61.
4. Losert W, Casals-Stenzel J, Buse M. Progestogens with antimineralcorticoid activity. Arzneimittelforschung, 1985, 35: 459-71.
5. Muhn P, Fuhrmann U, Fritzemeier KH, et al. Drospirenone: a novel progestogen with anti-mineralcorticoid and antiandrogenic activity. Ann N Y Acad Sci, 1995, 761: 311-35.
6. Oelkers W, Helmerhorst FM, Wuttke W, et al. Effect of an oral contraceptive containing drospirenone on the rennin-angiotensin-aldosterone system in healthy female volunteers. Gynecol Endocrinol, 2000, 14: 204-13.
7. Fuhrmann U, Krattenmacher R, Slater EP, et al. The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential. Contraception, 1996, 54: 243-51.
8. van Vloten WA, van Haselen CW, van Zuuren El, Gerlinger C, Heithecker R. The effect of 2 combined oral Contraceptives containing either drospirenone or cyproterone acetate on acne and seborrhea. Cutis, 2002, Apr. 69(Suppl. 4): 2-15.
9. Gaspard U, Endrikat J, Desager JP, Buicu C, Gerlinger C, Heithecker R. A randomized study on the influence of oral contraceptives containing ethinylestradiol combined with drospirenone or desogestrel on lipid and lipo-protein metabolism over a period of 13 cycles. Contraception, 2004, Apr. 69(4): 271-8.
10. Pinter B. Continuation and compliance of contraceptive use. Eur J Contracept Reprod Health Care, 2002, Sep. 7(3): 178-83. Review. PMID: 12428939.
11. J.Verchaeghe. Hormonal contraception in women with metabolic syndrome. Contraception Reproductive Health Care, 2010, 5 (5): 305-314.
12. A. Motivala, B. Pitt. Drospirenone fore Oral Contraception and Hormone Replacement Therapy. Drugs, 2007, 7(5): 47-655.
13. Halpeich U, Backstrom T et al. Clinical diagnostic criteria for premenstrual syndrome and guidelines for research studies. Genecolodical Endocrinjlogy, 2007, 23(3): 123-130.
14. Paul G, Bell C et al. The real deal: A feasibility study of peer-led sex education for early school leavers. Contraception Reproductive Health Care, 2010, 5(5): 343-357
15. Simpson RC, Grindlay DJ, Williams HC. What's new in acne? An analysis of systematic reviews and clinically significant trials published in 2010-11. Clin. Exp. Dermatol., 2011, 36(8): 840843; quiz 843-4. doi: 10.1111/j.1365-2230. 2011.04218.x. Review.
Review
For citations:
Yenkova EV. Effect of a new oral contraceptive on metabolism and the cardiovascular system. Meditsinskiy sovet = Medical Council. 2015;(XX):10-13. (In Russ.) https://doi.org/10.21518/2079-701X-2015-XX-10-13
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