Why do acute respiratory infections in children remain a pressing problem? Current, prevention and treatment options
https://doi.org/10.21518/2079-701X-2019-17-198-206
Abstract
Literary data on peculiarities of immune system, anti-infectious immunity, including local protection of respiratory tract (lymphaticepithelial pharyngeal system), in children of early and preschool age, causing their higher incidence of acute respiratory infections (ARI) are given in the article. This age period is characterized by «physiological» humoral immune deficiency, reduced activation of the complement system, insufficient synthesis of cytokines, including interferons, T-cell immunosuppression, impaired intercellular cooperation, poor functional activity of natural killers and phagocytes. Despite the large range of means and methods of prophylaxis of infectious and inflammatory diseases of viral and bacterial etiology, it is necessary to search for new approaches taking into account the peculiarities of immune status in young children. The article presents the possibilities of controlling the system of congenital and adaptive immunity with medications, in particular, by using the bacterial lysate Broncho-munal®. The immunoregulatory role of bacterial lysates is presented in detail. The pathogenetic substantiation of the use of bacterial lysate Broncho-munal® for the prevention of acute respiratory infections in children, including children with recurrent respiratory infections is given.
About the Authors
E. V. Kanner
Federal State Institution of Science «Central Research Institute of Epidemiology of Rospotrebnadzor»
Russian Federation
Kanner Ekaterina Valer’yevna, Cand. of Sci. (Med.), Senior Researcher of the Clinical Department of Infectious Pathology
Russian Federation
Kanner Ekaterina Valer’yevna, Cand. of Sci. (Med.), Senior Researcher of the Clinical Department of Infectious Pathology
3A, Novogireevskaya str., Moscow, 111123
A. V. Gorelov
Federal State Institution of Science «Central Research Institute of Epidemiology of Rospotrebnadzor»;
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Gorelov Aleksandr Vasil’yevich, Dr. of Sci.(Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Deputy Director for Research of the Federal State Institution of Science «Central Research Institute of Epidemiology of Rospotrebnadzor», Professor of the Department of Children’s Diseases of the Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
3A, Novogireevskaya str., Moscow, 111123,
p. 2, 8, Trubetskaya Street, Moscow, 119991
D. V. Pechkurov
Federal State Budgetary Educational Institution of Higher Education «Samara State Medical University of the Ministry of Health of the Russian Federation»
Russian Federation
Russian Federation
Pechkurov Dmitriy Vladimirovich, Dr. of Sci. (Med.), Professor, Head of the Department of Children’s Diseases
liter B, 165, Karl Marx Avenue, Samara, 443079
M. L. Maksimov
Kazan State Medical Academy, a branch of the Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuous Professional Education» of the Ministry of Health of the Russian Federation;
Federal State Budgetary Educational Institution of Higher Education «Russian National Research Medical University named after N.I. Pirogov» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Maksimov Maxim Leonidovich, Dr. of Sci. (Med.), Chief Freelance Specialist Clinical Pharmacologist of the Ministry of Health of the Republic of Tatarstan, Head of the Department of Clinical Pharmacology and Pharmacotherapy of the Kazan State Medical Academy, a branch of the Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuous Professional Education» of the Ministry of Health of the Russian Federation, Professor, Department of Pharmacology, Paediatric Faculty, Federal State Budgetary Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University», Ministry of Health of the Russian Federation
11, Musthari St., Kazan, 420012,
1, Ostrovityanova St., Moscow, 117997
A. S. Ermolayeva
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Ermolayeva Anna Savvichna, Cand. of Sci. (Med.), Associate Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases
p. 2, 8, Trubetskaya Street, Moscow, 119991
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For citations:
Kanner EV, Gorelov AV, Pechkurov DV, Maksimov ML, Ermolayeva AS. Why do acute respiratory infections in children remain a pressing problem? Current, prevention and treatment options. Meditsinskiy sovet = Medical Council. 2019;(17):198-206. (In Russ.) https://doi.org/10.21518/2079-701X-2019-17-198-206
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