Possibilities of therapeutic use of HER2-inhibitorsin metastatic colorectal cancer: a case report
https://doi.org/10.21518/2079-701X-2019-19-126-131
Abstract
Current landscape of personalized and molecular-driven approach to cancer treatment contributes to a rapid growth of novel biomarkers used for a targeted therapy. Amplification or over-expression of HER2 has been shown to play an important role in the development and progression of some cancers. Recent studies have shown that over-expression of HER2 is found in up to 5% of colorectal cancers (CRC). These findings led to active research of therapeutic use of HER2-targeted therapy in a subset of patients with metastatic CRC, especially in patients with wild-type RAS, who progressed on anti-EGFR targeted therapy. According to data from several published studies, the rate of objective responses, progression-free and overall survival in this subset of patients matches or exceeds same rates that are achieved while using BRAF-targeted therapies in BRAF-mutated metastatic CRC patients and immunotherapy used in subjects diagnosed with MSI-H tumors. Currently, there is no conclusive data on potential of HER2-targeted therapy in RAS-mutated CRC patients. In this paper, we report a case of durable objective response obtained on trastuzumab therapy in patient with metastatic CRC, mutation in 12th exon of KRAS gene and over-expression of HER2 in 40% of tumor cells, after progression on several lines of chemotherapy and anti-angiogenic targeted therapy.
About the Authors
A. A. Kachmazov
Federal State Budgetary Institution «National Medical Research Radiological Center» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Junior Researcher, Department of Antitumor Drug Therapy
3, 2-nd Botkinskiy proezd, Moscow, 125284, Russia
SPIN-code: 7547-7725; AuthorID: 1041704
L. V. Bolotina
Federal State Budgetary Institution «National Medical Research Radiological Center» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of Chemotherapy Unit, Department of Antitumor Drug Therapy
3, 2-nd Botkinskiy proezd, Moscow, 125284, Russia
SPIN-code: 2787-5414; AuthorID: 594953
A. L. Kornietskaya
Federal State Budgetary Institution «National Medical Research Radiological Center» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Senior Researcher, Chemotherapy Unit, Department of Antitumor Drug Therapy
3, 2-nd Botkinskiy proezd, Moscow, 125284, Russia
SPIN-code: 2651-7158; AuthorID: 951395
T. V. Ustinova
Federal State Budgetary Institution «National Medical Research Radiological Center» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Physician of Chemotherapy Unit, Department of Antitumor Drug Therapy
3, 2-nd Botkinskiy proezd, Moscow, 125284, Russia
SPIN-code: 3638-0120; AuthorID: 951518
V. A. Tolstov
Federal State Budgetary Institution «National Medical Research Radiological Center» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Resident Physician of Chemotherapy Unit, Department of Antitumor Drug Therapy
3, 2-nd Botkinskiy proezd, Moscow, 125284, Russia
A. A. Fedenko
Federal State Budgetary Institution «National Medical Research Radiological Center» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Head of Department of Antitumor Drug Therapy
3, 2-nd Botkinskiy proezd, Moscow, 125284, Russia
SPIN-code: 9847-7668; AuthorID: 823233
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Review
For citations:
Kachmazov AA, Bolotina LV, Kornietskaya AL, Ustinova TV, Tolstov VA, Fedenko AA. Possibilities of therapeutic use of HER2-inhibitorsin metastatic colorectal cancer: a case report. Meditsinskiy sovet = Medical Council. 2019;(19):126-131. (In Russ.) https://doi.org/10.21518/2079-701X-2019-19-126-131
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