Possibilities of topical antibacterial drugs in practice of ENT-doctors
https://doi.org/10.21518/2079-701X-2020-4-94-98
Abstract
Introduction. Antibiotic resistance is a topic that is currently causing concern for all of humanity in the world. Experts at the World Health Organization consider it a global threat. Irrational and uncontrolled use of antibacterial drugs, the low level of prevention of bacterial and viral infections have led to an increase in mutations and the emergence of new resistant strains of microorganisms. The growth of antimicrobial resistance dictates the search for alternatives to systemic antibiotic therapy. In this connection, the search for an alternative to systemic antibiotic therapy is relevant.
Goal of research. This article discusses the use of a topical antibacterial drug tiamphenicol glycinate acetylcysteinate, which is a combination of a broad-spectrum antibiotic and a mucolytic.
Materials and methods. A literature review was conducted with an analysis of scientific research data on the effectiveness of the topical antibacterial drug tiamphenicol glycinate acetylcysteinate.
Results. In the practice of an otorhinolaryngologist topical use of tiamphenicol glycinate acetylcysteinate, including inhalation, helps to improve the course and prognosis of the disease, reduce the recovery time, and in some cases, reduce the systemic antibiotic use.
Conclusion. The obtained data allow us to recommend topical antibacterial drug tiamphenicol glycinate acetylcysteinate for use in otorhinolaryngological practice.
About the Authors
K. V. EremeevaRussian Federation
Kseniya V. Eremeeva - Cand. of Sci. (Med.), Associate Professor of the Department of Ear, Throat and Nose Diseases, Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University).
8, p. 2, Trubetskaya St., Moscow, 119991.
V. M. Svistushkin
Russian Federation
Valeriy M. Svistushkin - Dr. of Sci. (Med.), professor, Head of the Department of Ear, Throat and Nose Diseases, Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University).
8, p. 2, Trubetskaya St., Moscow, 119991.
Ya. A. Turutina
Russian Federation
Yana A. Turutina - Resident of the Department of Ear, Throat and Nose Diseases, Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University).
8, p. 2, Trubetskaya St., Moscow, 119991.
References
1. Piskunov S.Z., Piskunov G.Z. Morphological and functional features of the nasal mucous membrane and the paranasal sinuses. Principles of sparing endonasal surgery. Training manual for physicians. Moscow: Medical and Health Association of the Council of Ministers of the Soviet Union; 1991. (In Russ.)
2. Pal'chun V.T. (ed.). National Manual on Otolaryngology. Moscow: GEOTARMedia; 2009. (In Russ.)
3. Kolosova N.G., Kolosova A.B. Topical issues of inhaled antibacterial therapy of respiratory diseases in children. Meditsinskiy sovet = Medical Council. 2018;(17):128-131. (In Russ.) doi: 10.21518/2079-701X-2018-17-128-131.
4. Rachina S., Kozlov R., Tatochenko V.K. et al. Paediatricians approach to prescribing of systemic antimicrobials in outpatient children with upper respiratory tract and ENT infections:data from multicenter survey. Klinicheskaya farmakologiya i terapiya = Clinical Pharmacology and Therapy. 2016;25(2):20-27. (In Russ.) Available at: https://clinpharm-journal.ru/files/articles/praktika-lecheniya-ostryh-respiratornyh-infektsij-u-detej-v-ambulatorno-poliklinicheskih-uchrezhdeniyah-rf-rezultaty-mnogotsentrovogo-farmakoepidemiologicheskogo-issledovaniya.pdf.
5. Benninger M.S., Holy C.E., Track D. Acute rhinosinusitis: prescription patterns in real-world setting. Otolaryngol Head Neck Surg. 2016;154(5):957-962. doi: 10.1177/0194599816630310.
6. Sharp H.J., Denman D., Puumala S., Leopold D.A Treatment of acute and chronic rhinosinusitis in the United States. Arch Otolaryngol Head Neck Surg. 2007;133(3):260-265. doi: 10.1001/archotol.133.3.260.
7. Geppe N.A., Kolosova N.G., Dronov I.A. An experience of treatment of acute bronchitis using thiamphenicol glycinate acetylcisteinate in children. RMZH = RMG. 2016;(6):386-390. (In Russ.) Available at: https://www.rmj.ru/articles/pediatriya/Effektivnosty_primeneniya_tiamfenikola_glicinat_acetilcisteinata_pri_ostryh_bronhitah_u_detey/
8. Yakovleva V.P., Yakovleva S.V. Rational antimicrobial pharmacotherapy. Manual for Practitioners. Moscow: Litterra; 2003. 1008 p. (In Russ.)
9. Radzig E.Yu. Antibacterial drugs in ENT pathology in children: indications and ways of administration. Pediatriya. Zhurnal imeni G.N. Speranskogo = Journal “Pediatria” named after G.N. Speransky. 2013;92(1):111-117. (In Russ.) Available at: https://pediatriajournal.ru/files/upload/mags/327/2013_1_3610.pdf.
10. Yurgel' N.V. State Register of Medicinal Remedies: official edition (as of April 1, 2009). In 2 vol. Moscow: Meditsinskiy sovet; 2009. (In Russ.)
11. Angotoeva I.B., Pshennikov D.S. The inhalation therapy of moderate forms of acute bacterial rhinosinusitis. Meditsinskiy sovet = Medical Council. 2018;(6):84-88. (In Russ.) doi: 10.21518/2079-701X-2018-6-84-88.
12. Kunelskaya N.L., Turovskiy A.B., Izotova G.N., Talalayko Y.V., Kiselyova O.A. Options for the use of combination inhalers in the treatment of acute sinusitis. Meditsinskiy sovet = Medical Council. 2014;(3):28-31. (In Russ.) doi: 10.21518/2079-701X-2014-3-28-31.
13. Shcherbakov D.A., Tyryk O.B., Krotova A.S. et al. Russian patent of 2018; IPC A61K31/195 A61P11/02. (In Russ.) Available at: https://patenton.ru/patent/RU2646806C1.
14. Balyasinskaya G.L., Bogomil'skiy M.R., Lyumanova S.R. Experience of application of topical mucolytic drugs in treatment of rhinosinusitis in children. Pediatriya. Zhurnal imeni G.N. Speranskogo = Journal “Pediatria” named after G.N. Speransky. 2005;84(6):61-64. (In Russ.) Available at: https://elibrary.ru/item.asp?id=9173290.
15. Kirichenko I.M. Topic inhaled antibiotic therapy in children with prolonged adenoiditis. Rossiyskiy Vestnik Perinatologii i Pediatrii = Russian Bulletin of Perinatology and Pediatrics. 2019;64(3):87-90. (In Russ.) doi: 10.21508/10274065-2019-64-3-87-90.
16. Kryukov A.I., Kunelskaya N.L., Romanenko S.G., Pavlikhin O.G., Eliseyev O.V., Yakovlev V.S., Krasnikova D.I., Lesogorova E.V. Treatment of inflammatory diseases of the throat. Meditsinskiy sovet = Medical Council. 2013;(2):38-41. (In Russ.) doi: 10.21518/2079-701X-2013-2-38-41.
Review
For citations:
Eremeeva KV, Svistushkin VM, Turutina YA. Possibilities of topical antibacterial drugs in practice of ENT-doctors. Meditsinskiy sovet = Medical Council. 2020;(4):94-98. (In Russ.) https://doi.org/10.21518/2079-701X-2020-4-94-98