Features of laboratory diagnostics of undifferentiated connective tissue dysplasia in women with genital prolapse

Introduction. The issues of connective tissue dysplasia are currently highly urgent, particularly when it comes to the increase in a woman’s life expectancy and high incidence rates of the disease. According to various sources, the incidence of undifferentiated connective tissue dysplasia (uCTD) reaches 80%.

The purpose and objectives. Determine laboratory criteria for the diagnosis of undifferentiated connective tissue dysplasia (UCTD) in women with genital prolapse.

Relevance. In clinical practice, a point-based approach to the UCTD is widely used, when each phenotypic sign is evaluated by a certain number of points, the sum of which allows you to rank the manifestations of the pathology by severity. At the same time, implicit phenotypic manifestations of UCTD, which are accompanied by failure.

Material and research methods. We conducted a survey of 204 women with genital prolapse, who were divided into 2 groups. The main group consisted of 97 women with signs of UCTD, a comparison group of 107 patients without UCTD. The age of women in the main group was on average 54.2(2.5) years, in the comparison group 56.3 (1.9) years (p > 0.05). At the time of the survey, all women were in menopause from 3 to 6 years. In addition to registering phenotypic stigmas, methods for diagnosing UCTD included determining the content of amino acids in the blood serum that are involved in the synthesis of collagen and elastin, estradiol, and hormonal parameters of the thyroid system. To evaluate changes in laboratory parameters: the content of amino acids in blood serum, estradiol, the hormonal profile of the thyroid gland.

Results. We analyzed the serum levels of amino acids (Proline, lysine, and hydroxyproline) involved in the synthesis of collagen and elastin.in women with undifferentiated connective tissue dysplasia, deviations in their content from the norm were detected. Conclusion. In women with prolapse of the genitals, it is necessary to diagnose UCTD, which must be confirmed by the amino acid profile, densitometry and hormonal diagnostics of the state of thyroid function.

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