Effectiveness of topical therapy of secondarily infected atopic dermatitis in children

Abstract

Introduction. In present day conditions, atopic dermatitis is characterized by an early onset, persistent relapsing course, development of complications and has certain difficulties in treatment. Nowadays, in unfavourable environmental context and irrational use of antibiotics, bacterial and fungal infection is one of the factors leading to the aggravation of atopic dermatitis, which plays an important role in maintaining a chronic inflammatory process in the skin.
Aim. To improve methods for treating atopic dermatitis complicated by fungal and bacterial infection in children by using non-steroidal activated zinc pyrithione drug (in the form of 0.2% cream or 0.2% aerosol), which has antimicrobial and antifungal, as well as anti-inflammatory effects.
Materials and methods. 46 children aged 1 to 3 years with complicated forms of atopic dermatitis were observed. They used activated zinc pyrithione drug applied topically as part of the complex antiallergic therapy.
Results and discussion. The on-going therapy resulted in a positive clinical effect in 69.5% of cases and the achievement of a stable remission of the disease on average on the 16th day from the start of therapy. The results of cultural bacteriological and mycological examination were negative in 78.1% of cases. The one-year dynamic follow-up of children showed that 53.1% had a stable remission of the disease, and 28.1% of children had exacerbations observed after treatment, which were characterized by a lower intensity of clinical manifestations.
Conclusions. The introduction of a nonsteroidal activated zinc pyrithione drug (0.2% cream or 0.2% aerosol) as topical monotherapy in the complex treatment of atopic dermatitis complicated by secondary fungal and bacterial infection showed high clinical efficacy.