The use of combined topical glucocorticosteroids in infectious dermatitis of the folds
https://doi.org/10.21518/ms2025-263
Abstract
The article describes clinical cases of the use of a combined topical glucocorticosteroid (THCS) (Acriderm GK drug) in the form of a cream (in the version: betamethasone + gentamicin + clotrimazole) to update data on its effectiveness in infectious dermatitis of the folds. The patients were prescribed the drug as the main treatment according to the scheme: apply a small amount of cream to the affected areas of the skin, lightly rubbing, 2 times a day.
Results. Patient A., 52 years old, was diagnosed with infectious dermatitis of the large folds of the perineum (intercostal and perineo-scrotal folds) and vitiligo of the intercostal fold. Prior to treatment, erythema with slight swelling of the skin and vitiligo were locally noted. Relief of erythema, swelling, and a decrease in the area of the leukoderma were noted 15 days after the start of treatment. A clinical cure has been established. Patient B., 55 years old, was diagnosed with infectious dermatitis of the transverse fold of the anterior abdominal wall. Prior to treatment, severe hyperemia, weeping, and soreness with slight peeling were locally noted. A clinical cure was established 14 days after the start of treatment.
Conclusion. The high therapeutic efficacy of combined THC in the form of a cream for external use (Acriderm GK) has been shown for various types of infectious dermatitis of the folds, including with primary lesions of the folds, and with existing chronic dermatoses in this area.
About the Author
N. V. Shperling
Reaviz University
Russian Federation
Russian Federation
Natalia V. Shperling, Dr. Sci. (Med.), Professor, Professor of the Department of Clinical Medicine
8, Bldg. 2а, Kalinin St., St Petersburg, 198095
References
1. Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009;326(5960):1694–1697. https://doi.org/10.1126/science.1177486.
2. Shperling NV, Shperling IA, Chaplygin AV, Ustinov MV. Topical drugs for acne treatment. Klinicheskaya Dermatologiya i Venerologiya. 2021;20(6):66–70. (In Russ.) https://doi.org/10.17116/klinderma20212006166.
3. Shperling NV, Shperling IA, Yurkevich SW. The effectiveness of external therapy of dyshidrotic eczema with a combined drug. Klinicheskaya Dermatologiya i Venerologiya. 2020;19(2):200–204. (In Russ.) https://doi.org/10.17116/klinderma202019021200.
4. Кубанов АА, Хардикова СА, Заславский ДВ, Новиков ЮА, Радул ЕВ, Правдина ОВ и др. Экзема: клинические рекомендации. 2021. Режим доступа: https://www.rodv.ru/klinicheskie-rekomendacii/.
5. Кубанов АА, Поддубная ИВ, Белоусова ИЭ, Самцов АВ, Знаменская ЛФ, Чикин ВВ и др. Грибовидный микоз: клинические рекомендации. 2021. Режим доступа: https://www.rodv.ru/klinicheskie-rekomendacii/.
6. Katsambas AD, Lotti TM. European Handbook of Dermatological Treatments. М.: МЕД-пресс-информ; 2014. 724 с.
7. Шперлинг МИ, Шперлинг НВ. Экстрагенитальная патология и беременность. Диагностика и лечение. М.: ГЭОТАР-Медиа; 2023. 208 с.
8. Adwan K, Abu-Hasan N. Gentamicin resistance in clinical strains of Enterobacteriaceae associated with reduced gentamicin uptake. Folia Microbiol. 1998;43(4):438–440. https://doi.org/10.1007/BF02818588.
9. Ausili A, Yakymenko I, Teruel JA, Gómez-Fernández JC. Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane. Biomolecules. 2021;2;11(9):1304. https://doi.org/10.3390/biom11091304.
10. Lobko SS, Khomenko AI. Common rationally pharmacotherapeutics of oral fungal diseases. Meditsinskie Novosti. 2016:(2):54–60. (In Russ.) Available at: https://www.mednovosti.by/Journal.aspx?id=338.
11. Rzayeva RN, Mozgovaya EV, Palgova LC. Liver steatosis at women with obesity. The features of pregnancy. Journal of Obstetrics and Women’s Diseases. 2014;63(6):55–65. (In Russ.) Available at: https://journals.eco- vector.com/jowd/issue/view/161.
12. Alamri ZZ. The role of liver in metabolism: an updated review with physiological emphasis. J Basic Clin Pharmacol. 2018;7(11):2271–2276. https://doi.org/10.18203/2319-2003.ijbcp20184211.
13. Varpit F, Galama V. Human Blood. In: Blood Groups – More than Inheritance of Antigenic Substances. 2022.
14. Yudina YuV, Korsunsky AA, Aminova AI, Abdullayeva GD, Prodeus AP. Gut microbiota as a separate body system. Russian Journal of Evidence-Based Gastroenterology. 2019;8(4-5):36–43. (In Russ.) https://doi.org/10.17116/dokgastro2019804-05136.
Review
For citations:
Shperling NV. The use of combined topical glucocorticosteroids in infectious dermatitis of the folds. Meditsinskiy sovet = Medical Council. 2025;19(13):269-272. (In Russ.) https://doi.org/10.21518/ms2025-263
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