Combination therapy for acute tonsillopharyngitis

Introduction. The clinical manifestations of acute tonsillopharyngitis (ATP) are varied, the combined use of topical medications with synergistic and complementary mechanisms of action in various dosage forms is of practical interest.

Aim. To study the effectiveness of combination topical therapy for ATP in adults and children using ambazon and benzydamine.

Materials and methods. From March to May 2025, a multicenter clinical observational study was conducted in Samara among patients who sought medical attention from an otolaryngologist complaining of sore throat. To exclude the possible etiology of ATP due to Group A beta-hemolytic streptococcus, the otolaryngologist performed a rapid diagnostic procedure at the initial consultation. The study group included 30 patients, 13 children and 17 adults (mean age 24.9 ± 15.1 years). All patients received a combination of ambazon and benzydamine at the recommended dosage.

Results and discussion. Treatment effectiveness was assessed on days 2, 3, and 5 of treatment, as well as 2 days after the end of the treatment period. By day 2, sore throat was completely relieved in 10% of patients, and another 40% of patients expe­rienced a reduction in throat pain intensity. The VAS score was 3.8 ± 2.3 points, compared to the baseline of 6.7 ± 2.6 points (p < 0.001). By the end of treatment, sore throat was completely relieved in 50% of patients, and the pain intensity score for another 50% was 0.6 ± 0.6 points. A patient survey on day 7 revealed that 96.7% (n = 29) of patients had no sore throat.

Conclusions. The obtained data on a significant regression of objective and subjective signs of ATP, including a reduction in inflammatory changes in the pharyngeal mucosa, indicate the feasibility of using the studied combination in the compre­hensive treatment of ATP in adults and children.

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