Preview

Meditsinskiy sovet = Medical Council

Advanced search

Recurrent respiratory infections – modern possibilities of a pediatrician

https://doi.org/10.21518/ms2025-488

Abstract

Frequent acute respiratory infections in children are not only a medical problem but also a socioeconomic one for both individual families and the country as a whole. Identifying the causes and effective monitoring and treatment algorithms for patients with upper respiratory infections is crucial for developing comprehensive national prevention and control strategies, as well as for more efficient allocation and use of healthcare resources. The number of episodes of acute respiratory infection during the year may vary in children depending on age, climate zone, socialization of the child and many other factors. Children susceptible to recurrent (repeated) cases of acute respiratory infections were previously called “frequently ill children” in our country. Allergies, immunodeficiencies, persistent opportunistic infections, functional digestive disorders, chronic diseases of the ENT organs and some other problems may be hidden under the guise of a “frequently ill child” or a child with recurrent respiratory infections, as such a patient is called today. A pediatrician must identify the true cause of frequent episodes of acute respiratory infections in such a child, as this will allow determining the tactics of his observation, the algorithm of diagnostic examination and, if necessary, optimizing the methods of therapy. It is extremely important in children with recurrent infections to adequately approach the treatment of each episode of respiratory infection, using modern possibilities of antiviral therapy, including drugs based on a combination of normal human immunoglobulin and recombinant interferon α-2b.

About the Authors

E. E. Lokshina
Russian University of Medicine (ROSUNIMED); Children’s State Hospital of St Vladimir
Россия

Evelina E. Lokshina, Cand. Sci. (Med.), Professor of the Department of Pediatrics; Allergist- Immunologist

4, Dolgorukovskaya St., Moscow, 127006

12А, Matrosskaya Tishina St., Moscow, 107014



O. V. Zaytseva
Russian University of Medicine (ROSUNIMED); Children’s State Hospital of St Vladimir
Россия

Olga V. Zaytseva, Dr. Sci. (Med.), Professor, Head of the Department of Pediatrics; Pediatrician

4, Dolgorukovskaya St., Moscow, 127006

12А, Matrosskaya Tishina St., Moscow, 107014



S. A. Vlasova
Russian University of Medicine (ROSUNIMED)
Россия

Svetlana A. Vlasova, Senior Laboratory Assistant of the Department of Pediatrics

4, Dolgorukovskaya St., Moscow, 127006

 



S. V. Zaytseva
Russian University of Medicine (ROSUNIMED); Federal Scientific Clinical Center for Children and Adolescents
Россия

Svetlana V. Zaytseva, Cand. Sci. (Med.), Associate Professor of the Department of Pediatrics; Pulmonologist

4, Dolgorukovskaya St., Moscow, 127006

20, Moskvorechye St., Moscow, 115409



N. A. Savitskaya
Children’s State Hospital of St Vladimir
Россия

Natalia A. Savitskaya, Cand. Sci. (Med.), Head of the 1st Pediatric Department

12А, Matrosskaya Tishina St., Moscow, 107014



T. Yu. Belyaeva
Children’s State Hospital of St Vladimir
Россия

Tatiana Yu. Belyaeva, Deputy Chief Physician for Medical Affairs

12А, Matrosskaya Tishina St., Moscow, 107014



A. V. Kulikov
Peoples’ Friendship University of Russia named after Patrice Lumumba
Россия

Andrey V. Kulikov, Cand. Sci. (Biol.), Associate Professor of the T.T. Berezov Department of Biochemistry

6, Miklukho-Maklai St., Moscow, 117198



References

1. Zhang SX, Liu YJ, Tan EL, Yang GB, Wang Y, Hu XJ et al. Global, regional, and national burden of upper respiratory infections, 1990–2021: Findings from the Global Burden of Disease study 2021. Sci One Health. 2024;3:100084. https://doi.org/10.1016/j.soh.2024.100084.

2. GBD 2021 Upper Respiratory Infections Otitis Media Collaborators. Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021. Lancet Infect Dis. 2025;25(1):36–51. https://doi.org/10.1016/S1473-3099(24)00430-4.

3. Косенко ИМ. Реккурентные респираторные инфекции у детей: современные подходы к рациональной фармакотерапии. Педиатрия. Consilium Medicum. 2018;(1):51–56. Режим доступа: https://omnidoctor.ru/library/izdaniya-dlya-vrachey/pediatriya-consilium-medicum/ped2018/ped2018_1/rekurrentnye-respiratornye-infektsii-u-detey-sovremennyepodkhody-k-ratsionalnoy-farmakoterapii/.

4. Заплатников АЛ, Гирина АА, Локшина ЭЭ, Леписева ИВ, Майкова ИД, Кузнецова ОА и др. Часто болеющие дети: все ли решено? Медицинский совет. 2018;(17):206–212.

5. Зайцева ОВ, Локшина ЭЭ. Рекуррентные респираторные заболевания у детей. М.; 2015. 72 с.

6. Pasternak G, Lewandowicz-Uszyńska A, Królak-Olejnik B. Recurrent respiratory tract infections in children. Pol Merkur Lekarski. 2020;49(286):260–266. Available at: https://pubmed.ncbi.nlm.nih.gov/32827422/.

7. de Martino M, Ballotti S. The child with recurrent respiratory infections: normal or not? Pediatr Allergy Immunol. 2007;18(18):13–18. https://doi.org/10.1111/j.1399-3038.2007.00625.x.

8. Chiappini E, Santamaria F, Marseglia GL, Marchisio P, Galli L, Cutrera R et al. Prevention of recurrent respiratory infections. Ital J Pediatr. 2021;47(1):211. https://doi.org/10.1186/s13052-021-01150-0.

9. Zhou B, Niu W, Liu F, Yuan Y, Wang K, Zhang J et al. Risk factors for recurrent respiratory tract infection in preschool-aged children. Pediatr Res. 2021;90(1):223–231. https://doi.org/10.1038/s41390-020-01233-4.

10. Ciprandi G, La Mantia I, Damiani V, Passali D. Local Bacteriotherapy – a promising preventive tool in recurrent respiratory infections. Expert Rev Clin Immunol. 2020;16(11):1047–1052. https://doi.org/10.1080/1744666X.2021.1833720.

11. Zhukova LI. Recurrent respiratory infections in children (differential diagnostics, rehabilitation). Okhrana Materinstva i Detstva. 2024;1(43):81–82. (In Russ.) Available at: https://elibrary.ru/aeppux.

12. Yang IA, Jenkins CR, Salvi SS. Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment. Lancet Respir Med. 2022;10(5):497–511. https://doi.org/10.1016/S2213-2600(21)00506-3.

13. Ozkan H, Atlihan F, Genel F, Targan S, Gunvar T. IgA and/or IgG subclass deficiency in children with recurrent respiratory infections and its relationship with chronic pulmonary damage. J Investig Allergol Clin Immunol. 2005;15(1):69–74. Available at: https://pubmed.ncbi.nlm.nih.gov/15864886/

14. Collaro AJ, McElrea MS, Marchant JM, Chatfield MD, Sondergeld P, Perret JL et al. The effect of early childhood respiratory infections and pneumonia on lifelong lung function: a systematic review. Lancet Child Adolesc Health. 2023;7(6):429–440. https://doi.org/10.1016/S2352-4642(23)00030-5.

15. Schaad UB, Esposito S, Razi CH. Diagnosis and management of recurrent respiratory tract infections in children: a practical guide. Arch Pediatr Infect. 2016;4:e31039. Available at: https://www.researchgate.net/publication/290457394_Diagnosis_and_Management_of_Recurrent_Respiratory_Tract_Infections_in_Children_A_Practical_Guide.

16. Plotkin SA, Orenstein WA, Offit PA, Edwards KM. Plotkin’s Vaccines. 7th ed. Elsevier; 2017. 2331 p.

17. Chang AB, Oppenheimer JJ, Irwin RS. Managing Chronic Cough as a Symptom in Children and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2020;158(1):303–329. http://doi.org/10.1016/j.chest.2020.01.042.

18. Clementi N, Ghosh S, De Santis M, Castelli M, Criscuolo E, Zanoni I et al. Viral Respiratory Pathogens and Lung Injury. Clin Microbiol Rev. 2021;34(3):e00103-20. http://doi.org/10.1128/CMR.00103-20.

19. Denisov LA, Sholokhov IV. Interferon discovery and its clinical experience. Infectious Diseases: News, Opinions, Training. 2017;(1):23–31. (In Russ.) https://doi.org/10.24411/2305-3496-2017-00019.

20. Ершов ФИ. Интерферонам – 60 лет. Туберкулез и социально значимые заболевания. 2018;(2):71–77. Режим доступа: https://www.tb-journal.ru/jour/article/view/437. Ershov FI. Sixty years history of interferons. Tuberculosis and Socially Significant Diseases. 2018;(2):71–77. (In Russ.) Available at: https://www.tbjournal.ru/jour/article/view/437.

21. Pikuza OI, Zakirova AM, Volyanyuk EV, Filatov VS, Pikuza AV, Zakirov AM. Functional potential of colonization defense of buccal epitheliocytes as an indicator of the clinical course of respiratory tract diseases. Practical Medicine. 2023;21(1):76–80 (In Russ.) https://doi.org/10.32000/2072-1757-2023-1-76-80.

22. Pikuza OI, Faizullina RA, Zakirova AM, Moroz TB, Rashitova EL, Volyanyuk EV. Bacterial lysate in the therapy of acute and recurrent respiratory infections in children. Doctor.Ru. 2021;20(3):11–16. (In Russ.) Available at: https://journaldoctor.ru/catalog/pediatriya/bakterialnyy-lizat-vterapii-ostrykhi-retsidiviruyushchikh-infektsiy-dykhatelnykh-putey-u-detey/.

23. Kerimova MK. The effectivity of the Immunobiological preperat Kipferon in treatment of frequently ailing children. 2008;(5-6):292–294. (In Russ.) Available at: http://science-journal.kg/media/Papers/nntiik/2008/5/nntiik2008-N5-6-292-294.pdf.

24. Gorelov AV, Omarova HG, Belikova EE, Eremina OL, Dombayan SH, Zaitseva NS et al. Results of an open multicenter non-interventional observ ational prospective study of the effect on quality of life of the drug Kipferon® used in children 0–7 years old with acute respiratory viral infections in the conditions of routine outpatient practice. Clinical Practice in Pediatrics. 2024;19(1): 64–74. (In Russ.) https://doi.org/10.20953/1817-7646-2024-1-64-74.

25. Feklisova LV, Meskina ER, Galkina LA, Tselipanova EE, Kazakova SP, Savitskaya NA. Optimization of treatment results for viral and bacterial infections in children: an algorithm for using Kipferon® suppositories. RMJ. 2009;(7):468. Available at: https://www.rmj.ru/articles/infektsionnye_bolezni/Optimizaciya_rezulytatov_lecheniya__virusnobakterialynyh_infekciy_u_detey__algoritm_primeneniya_suppozitoriev_Kipferona/.

26. Zakirova AM, Moroz TB, Shayapova DT, Kadriev AG, Palmova LY, Rashitova et al. Influence of a combined interferon-alpha-containing drug on the course of respiratory diseases in frequently ill children. Meditsinskiy Sovet. 2023;(12):32–44. (In Russ.) https://doi.org/10.21518/ms2023-202.

27. Zhang X, Dai X, Li X, Xie X, Chen Y, Chen Y et al. Recurrent respiratory tract infections in children might be associated with vitamin A status: a casecontrol study. Front Pediatr. 2024;11:1165037. https://doi.org/10.3389/fped.2023.1165037.

28. Zaplatnikov AL, Girina AA, Burtseva EI, Lepiseva IV, Svintsitskaya VI, Leshik MV. Children with recurrent respiratory infections: state of the art. Russian Journal of Woman and Child Health. 2024;7(4):1–9. (In Russ.) https://doi.org/10.32364/2618-8430-2024-7-4-7.

29. Zhang Y, Xu Y, Hu L, Wang X. Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children. Front Pediatr. 2025;13:1508613. https://doi.org/10.3389/fped.2025.1508613.

30. Bellussi LM, Passali FM, Ralli M, De Vincentiis M, Greco A, Passali D. An overview on upper respiratory tract infections and bacteriotherapy as innovative therapeutic strategy. Eur Rev Med Pharmacol Sci. 2019;23(1):27–38. https://doi.org/10.26355/eurrev_201903_17345.


Review

For citations:


Lokshina EE, Zaytseva OV, Vlasova SA, Zaytseva SV, Savitskaya NA, Belyaeva TY, Kulikov AV. Recurrent respiratory infections – modern possibilities of a pediatrician. Meditsinskiy sovet = Medical Council. 2025;(19):248–254. (In Russ.) https://doi.org/10.21518/ms2025-488

Views: 158

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)