Why a pediatrician needs to know about the neurophysiological mechanisms underlying left-sidedness and left-handedness in children
https://doi.org/10.21518/ms2025-345
Abstract
Left-sidedness is a characteristic of individual typological features of a person. Left-handedness can be considered as a clear marker of functional brain asymmetry, which determines the specificity of the cognitive features of a child. Archaeological evidence confirms the existence of left-handedness among early ancestors, predating modern humans and living over a million years ago. This suggests that the left-handedness, as a marker of asymmetry, persists at a certain level due to evolutionary mechanisms, which contributes to the stability and adaptability of the species. Historical data indicate a high left-handedness stigma degree ingrained in people’s heads. Fundamental scientific research allowed us to do away with an evil practice of “correcting” left-handed children. The awakened scientific interest in neurophysiology has spurred the development of numerous hypotheses and theories to explain the phenomenon of left-handedness. However, there is no single generally accepted theory of this phenomenon. According to modern concepts, left-handedness is considered a manifestation of functional asymmetry in the brain performance. Asymmetry is a phenomenon that is observed at various levels and has certain forms of expression. In the prenatal period, the ontogenesis of the brain reveals a number of functional and anatomical asymmetries, which reflects the dynamic, multifaceted process of brain lateralization. The article discusses possible causes of left-handedness with an emphasis on the method of assessing a child’s hand dominance. The discovery of the phenomenon of lateralization is a major step towards understanding the mental characteristics and cognitive functions of children. The concept of these aspects of development underlies the individual approach both in pedagogical activity and in the context of interactions between pediatricians, patients, and their parents.
About the Authors
I. N. ZakharovaРоссия
Irina N. Zakharova, Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Head of the Department of Pediatrics named after Academician G.N. Speransky
2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993
V. D. Churilova
Россия
Viktoriya D. Churilova, Postgraduate Student of the Department of Pediatrics named after Academician G.N. Speransky
2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993
References
1. Postoeva VA, Pachomov VP. Modern neuropsychological conception of lefthanders phenomenon. Vestnik Tomskogo gosudarstvennogo pedagogicheskogo universiteta. 2010;(2):113–117. (In Russ.) Available at: https://www.elibrary.ru/mmbmtn.
2. Papadatou-Pastou M, Ntolka E, Schmitz J, Martin M, Munafò MR, Ocklenburg S, Paracchini S. Human handedness: A meta-analysis. Psychol Bull. 2020;146(6):481–524. https://doi.org/10.1037/bul0000229.
3. Papadatou-Pastou M, Martin M, Munafò MR, Jones GV. Sex differences in left-handedness: a meta-analysis of 144 studies. Psychol Bull. 2008;134(5):677–699. https://doi.org/10.1037/a0012814.
4. Movsesian AA. Anthropology of left-handedness: historical, evolutionary, and cultural aspects. Moscow University Biological Sciences Bulletin. 2025;(1):79–89. (In Russ.) https://doi.org/10.55959/MSU2074-8132-25-1-8.
5. McManus C. Right Hand, Left Hand: The Origins of Asymmetry in Brains, Bodies, Atoms and Cultures. Cambridge, MA: Harvard University Press; 2002. 412 р. Available at: https://books.google.ca/books?id=20oza63ZuG4C.
6. Milenkovic S, Belojević G, Paunovic K, Davidović D. Historical aspects of left-handedness. Srp Arh Celok Lek. 2019;147(11-12):782–785. https://doi.org/10.2298/sarh190522095m.
7. Llaurens V, Raymond M, Faurie C. Why are some people left-handed? An evolutionary perspective. Philos Trans R Soc Lond B Biol Sci. 2009;364(1519):881–894. https://doi.org/10.1098/rstb.2008.0235.
8. Gutwinski S, Löscher A, Mahler L, Kalbitzer J, Heinz A, Bermpohl F. Understanding left-handedness. Dtsch Arztebl Int. 2011;108(50):849–853. https://doi.org/10.3238/arztebl.2011.0849.
9. Corballis MC. Human Laterality. New York: Academic Press; 1983. 255 p. Available at: https://thelib.net/975152-human-laterality.html.
10. Ayrumyan GS. Historical aspect of the problem of left-handedness. Young Scientist. 2012;(11):387–389. (In Russ.) Available at: https://moluch.ru/archive/46/5681/.
11. de Campos D, Coutinho Rodrigues D, Buso L. The right hand of Leonardo da Vinci (1452–1519): ulnar or median nerve palsy? J R Soc Med. 2019;112(11):452. https://doi.org/10.1177/0141076819865886.
12. Lazzeri D. The handedness of Michelangelo Buonarroti. Clin Anat. 2018;31(5):645–647. https://doi.org/10.1002/ca.23203.
13. Безруких ММ, Князева МГ. Если ваш ребенок левша. Тула: Арктоус; 1996. 78 c. Режим доступа: https://psyinst.moscow/biblioteka/?part=article&id=2347.
14. Александров СГ. Функциональная асимметрия и межполушарные взаимодействия головного мозга. Иркутск: ИГМУ; 2014. 62 с. Режим доступа: https://irkgmu.ru/src/downloads/13f13c93_funktsionalnaya_asimmetriya_.pdf.
15. Corballis MC. The evolution and genetics of cerebral asymmetry. Philos Trans R Soc Lond B Biol Sci. 2009;364(1519):867–879. https://doi.org/10.1098/rstb.2008.0232.
16. Bisiacchi P, Cainelli E. Structural and functional brain asymmetries in the early phases of life: a scoping review. Brain Struct Funct. 2022;227(2):479–496. https://doi.org/10.1007/s00429-021-02256-1.
17. Ford A, Ammar Z, Li L, Shultz S. Lateralization of major white matter tracts during infancy is time-varying and tract-specific. Cereb Cortex. 2023;33(19):10221–10233. https://doi.org/10.1093/cercor/bhad277.
18. Olulade OA, Seydell-Greenwald A, Chambers CE, Turkeltaub PE, Dromerick AW, Berl MM et al. The neural basis of language development: Changes in lateralization over age. Proc Natl Acad Sci U S A. 2020;117(38):23477–23483. https://doi.org/10.1073/pnas.1905590117.
19. Behrmann M, Plaut DC. A vision of graded hemispheric specialization. Ann N Y Acad Sci. 2015;1359:30–46. https://doi.org/10.1111/nyas.12833.
20. Ocklenburg S, Mundorf A, Gerrits R, Karlsson EM, Papadatou-Pastou M, Vingerhoets G. Clinical implications of brain asymmetries. Nat Rev Neurol. 2024;20(7):383–394. https://doi.org/10.1038/s41582-024-00974-8.
21. Ocklenburg S, Friedrich P, Fraenz C, Schlüter C, Beste C, Güntürkün O, Genç E. Neurite architecture of the planum temporale predicts neurophysiological processing of auditory speech. Sci Adv. 2018;4(7):eaar6830. https://doi.org/10.1126/sciadv.aar6830.
22. Toga AW, Thompson PM. Mapping brain asymmetry. Nat Rev Neurosci. 2003;4(1):37–48. https://doi.org/10.1038/nrn1009.
23. Duboc V, Dufourcq P, Blader P, Roussigné M. Asymmetry of the Brain: Development and Implications. Annu Rev Genet. 2015;49:647–672. https://doi.org/10.1146/annurev-genet-112414-055322.
24. McManus C. Cerebral Polymorphisms for Lateralisation: Modelling the Genetic and Phenotypic Architectures of Multiple Functional Modules. Symmetry. 2022;14(4):814. https://doi.org/10.3390/sym14040814.
25. Badzakova-Trajkov G, Häberling IS, Roberts RP, Corballis MC. Cerebral asymmetries: complementary and independent processes. PLoS ONE. 2010;5(3):e9682. https://doi.org/10.1371/journal.pone.0009682.
26. Геодакян СВ. Homo Asimmetricus? Эволюционная теория асимметрии В.А. Геодакяна. М.; 2014. 156 с. Режим доступа: https://www.sci.aha.ru/ots/doc/book030.pdf.
27. O’Callaghan MJ, Burn YR, Mohay HA, Rogers Y, Tudehope DI. Handedness in extremely low birth weight infants: aetiology and relationship to intellectual abilities, motor performance and behaviour at four and six years. Cortex. 1993;29(4):629–637. https://doi.org/10.1016/s0010-9452(13)80286-9.
28. Williams CS, Buss KA, Eskenazi B. Infant resuscitation is associated with an increased risk of left-handedness. Am J Epidemiol. 1992;136(3):277–286. https://doi.org/10.1093/oxfordjournals.aje.a116493.
29. Powls A, Botting N, Cooke RW, Marlow N. Handedness in very-lowbirthweight (VLBW) children at 12 years of age: relation to perinatal and outcome variables. Dev Med Child Neurol. 1996;38(7):594–602. https://doi.org/10.1111/j.1469-8749.1996.tb12124.x.
30. Fagard J, De Agostini M, Huet V, Granjon L, Heude B. Is Handedness at Five Associated with Prenatal Factors? Int J Environ Res Public Health. 2021;18(7):3529. https://doi.org/10.3390/ijerph18073529.
31. Ittyerah M. Handedness in low-birthweight children: Insights in lateralization. Front Psychol. 2023;13:1018913. https://doi.org/10.3389/fpsyg.2022.1018913.
32. de Kovel CGF, Carrión-Castillo A, Francks C. A large-scale population study of early life factors influencing left-handedness. Sci Rep. 2019;9(1):584. https://doi.org/10.1038/s41598-018-37423-8.
33. Annett M. Left, Right, Hand and Brain: The Right Shift Theory. London, UK: Lawrence Erlbaum Associates; 1985. 488 p.
34. McManus IC. The inheritance of left-handedness. In: Bock GR, Marsh J (eds.). Biological Asymmetry and Handedness. Chichester, UK: Wiley; 1991, pp. 251–281. Available at: https://aldebaran.one/author/marsh_joan/kniga_biological_asymmetry_and_handedness/.
35. Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE et al. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry. 2007;12(12):1129–1139. https://doi.org/10.1038/sj.mp.4002053.
36. Cuellar-Partida G, Tung JY, Eriksson N, Albrecht E, Aliev F, Andreassen OA et al. Genome-wide association study identifies 48 common genetic variants associated with handedness. Nat Hum Behav. 2021;5(1):59–70. https://doi.org/10.1038/s41562-020-00956-y.
37. Schijven D, Soheili-Nezhad S, Fisher SE, Francks C. Exome-wide analysis implicates rare protein-altering variants in human handedness. Nat Commun. 2024;15(1):2632. https://doi.org/10.1038/s41467-024-46277-w.
38. Zverev YP, Chisi J. Is handedness related to health status? Malawi Med J. 2004;16(1):14–16. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC3345498/.
39. Richardson T, Gilman RT. Left-handedness is associated with greater fighting success in humans. Sci Rep. 2019;9(1):15402. https://doi.org/10.1038/s41598-019-51975-3.
40. Hepper PG, McCartney GR, Shannon EA. Lateralised behaviour in first trimester human foetuses. Neuropsychologia. 1998;36(6):531–534. https://doi.org/10.1016/s0028-3932(97)00156-5.
41. Ververs IA, de Vries JI, van Geijn HP, Hopkins B. Prenatal head position from 12–38 weeks. I. Developmental aspects. Early Hum Dev. 1994;39(2):83–91. https://doi.org/10.1016/0378-3782(94)90157-0.
42. Tan U, Tan M. Incidences of asymmetries for the palmar grasp reflex in neonates and hand preference in adults. Neuroreport. 1999;10(16):3253–3256. https://doi.org/10.1097/00001756-199911080-00001.
43. Annett M. A classification of hand preference by association analysis. Br J Psychol. 1970;61(3):303–321. https://doi.org/10.1111/j.2044-8295.1970.tb01248.x.
44. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9(1):97–113. https://doi.org/10.1016/0028-3932(71)90067-4.
45. Bryden MP. Measuring handedness with questionnaires. Neuropsychologia. 1977;15(4-5):617–624. https://doi.org/10.1016/0028-3932(77)90067-7.
46. Scharoun SM, Bryden PJ. Hand preference, performance abilities, and hand selection in children. Front Psychol. 2014;5:82. https://doi.org/10.3389/fpsyg.2014.00082.
47. Cavill S, Bryden P. Development of handedness: comparison of questionnaire and performance-based measures of preference. Brain Cogn. 2003;53(2):149–151. https://doi.org/10.1016/s0278-2626(03)00098-8.
48. Bryden PJ, Roy EA, Rohr LE, Egilo S. Task demands affect manual asymmetries in pegboard performance. Laterality. 2007;12(4):364–377. https://doi.org/10.1080/13576500701356244.
Review
For citations:
Zakharova IN, Churilova VD. Why a pediatrician needs to know about the neurophysiological mechanisms underlying left-sidedness and left-handedness in children. Meditsinskiy sovet = Medical Council. 2025;(19):304–312. (In Russ.) https://doi.org/10.21518/ms2025-345
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