Possibilities of essential phospholipids in alcoholic liver disease of terminal stage
https://doi.org/10.21518/2079-701X-2016-14-58-61
Abstract
Essential phospholipids (Essentiale Forte N, Aventis, France-Germany) in alcohol-associated hepatic cirrhosis improve the subjective state of patients, reduce manifestations of asthenic and dyspeptic syndromes, intensity of jaundice, have a positive effect on biochemical indicators of cytolysis and cholestasis. The conducted clinical study showed effectiveness of use of essential phospholipids as hepatoprotective agents for hepatic diseases of alcoholic etiology.
About the Authors
M. A. ButovRussian Federation
MD, Prof.
A. S. Vasilevskaya
Russian Federation
PhD
References
1. Галимова С.Ф. Лекарственные поражения печени (часть 1). Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012, 22(3): 38-48. / Galimova S.F. Druginduced hepatic lesions (Part 1). Rossiysky Zhurnal Gastroenterologii, Gepatologii, Koloproktologii, 2012, 22(3): 38-48.
2. Ливзан М.А., Лялюкова В.А. Алкогольная болезнь печени: современные аспекты диагностики и лечения. Медицинский совет, 2014, 13: 49-53. / Livzan M.A., Lyulyakova V.A. Alcoholic liver disease: modern aspects of diagnostics and therapy. Meditsinsky Sovet, 2014, 13: 49-53.
3. Немцов A.B., Андриенко Ю.В. Самоотчеты населения России о потреблении алкоголя. Наркология, 2007, 5: 58-61. / Nemtsov A.V., Andrienko Y.V. Self-reports of Russia about alcohol consumption. Narkologia, 2007, 5: 58-61.
4. EASL Clinical Practical Guidelines: Management of Alcoholic Liver Disease Hepatology, 2012, 5: 399-420.
5. Бобров А.Н., Белякин С.А., Плюснин С.В. Этиологический профиль циррозов печени с благоприятным и неблагоприятным исходами по данным 15-летнего наблюдения (1996–2010 гг.) в многопрофильном госпитале. Российский журнал гастроэнтерологии, гепатологии, колопрок- тологии, 2011, 21(1): 152. / Bobrov A.N., Belyakin S.A., Plyusnin S.V. Etio logical profile of hepatic cirrhosis with favourable and unfavourable outcomes by data of the 15-year long observation (1996 – 2010) in the multi-profile hospital. Rossiysky Zhurnal Gastro enterologii, Gepatologii, Koloproktologii, 2011, 21 (1): 152.
6. Jampana SC, Khan R. Pathogenesis of alcoholic hepatitis: Role of inflammatory signaling and oxidative stress. World J Hepatology, 2011, 3 (5): 114-117.
7. Global Health Observatory Data Repository URL: http://apps.who.int/gho/data/node.country.country-RUS.
8. Рум Р. Влияние потребления алкоголя на заболеваемость. Наркология, 2006, 4: 13-16. / Rum R. Effect of alcohol consumption on incidence rate. Narkologia, 2006, 4: 13-16.
9. Boyer JL. Liver cirrhosis and its development. Falk sumposium, 2011, 115: 244-257.
10. Еремина Е.Ю. Алкогольная болезнь печени. Архив внутренней медицины, 2012, 6(8): 50-55. / Eremina E.Y. Alcoholic liver disease. Arkhiv Vnutrenney Meditsiny, 2012, 6(8): 50.55
11. Трухан Д.И. Неалкогольная жировая болезнь печени, ассоциированная с ожирением: возможности эссенциальных фосфолипидов. Медицинский совет, 2016, 4: 116-122. / Trukhan D.I. Non-alcoholic fatty liver disease associated with obesity: possibilities of essential phospholipids. Meditsinsky Sovet, 2016, 4: 116-122.
12. Sas E, Grinevich V, Kravchuk O. Polyunsaturated phosphatidylcholine reduces insulin resistance and hepatic fibrosis in patients with alcoholic liver disease. Results of randomized blinded prospective clinical study. J Hepatology, 2011, 54: 207.
13. Lieber CS. Phosphatidyleholine protects against fibrosis and cirrosis in the baboon. Gastroenterology, 1994, 106: 152-159.
14. Gundermann KJ. Activity of essential phospholipids (EPL) from soybean in liver diseases. Pharmacol. Reports Pr., 2011, 63(3): 643–659.
15. Востриков В.В. Методы диагностики алкогольной зависимости. Обзоры по клинической фармакологии и лекарственной терапии, 2008, 6(4): 26-52. / Vostrikov V.V. Methods of alcoholic dependence diagnostics. Obzory po Klinicheskoy Farmakoloii I Lekarstvennoy Terapii, 2008, 6 (4): 26-52.
16. Gundermann et al. Essential phospholipids in fatty liver: a scientific update. Clinical and Experimental Gastroenterology 2016:9 105-117.
Review
For citations:
Butov MA, Vasilevskaya AS. Possibilities of essential phospholipids in alcoholic liver disease of terminal stage. Meditsinskiy sovet = Medical Council. 2016;(14):58-61. (In Russ.) https://doi.org/10.21518/2079-701X-2016-14-58-61