Efficacy of Isoket inhalation in patients with angina pectoris
https://doi.org/10.21518/2079-701X-2015-4-58-61
Abstract
The article tells about the key pharmacological properties of isosorbide dinitrate in aerosol. There is a brief overview of relevant articles with results of clinical trials of antianginal efficacy of the drug. In patients with limited physical activity due to angina pectoris, Isoket spray was associated with a relief of attacks and improved exercise tolerance, which had a favorable impact on the emotional condition. Isosorbide dinitrate in aerosol is highly effective both for relief and prevention of angina attacks.
Keywords
изосорбид,
динитрат,
Изокет,
аэрозоль,
стенокардия,
isosorbide dinitrate,
Isoket aerosol,
angina pectoris
About the Author
A. A. Kirichenko
the Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation
Russian Federation
References
1. Montalescot G, Sechtem U et al. 2013 ESC guidelines on the management of stable coronary artery disease. Eur. Heart J. doi:10.1093/eur-heartj/ent296.
2. Hutt V, Theodor R, Pabst G, Lutz D, Bonn R and Fritschi R. Bioavailability and pharmacokinetics of a new isosorbide dinitrate spray preparation in healthy volunteers. Arzneim Forsch/Drug Res. 1993, 43: 842-6.
3. Ольбинская Л.И., Сизова Ж.М., Ушакова А.В. Сравнительная эффективность, безопасность, кардиогемодинамические эффекты аэрозоля изосорбида динитрата и сублингвальных таблеток нитроглицерина. Терапевтический архив, 1998, 5: 69-72.
4. Vogt D, Trenk D, Bonn R and Jahnchen E. Pharmacokinetics and haemo-dynamic effect of ISDN following different dosage forms and routes of administration. Eur J Clin. Pharmacol., 1994, 46: 319-324.
5. Marmor A. Comparative evaluation of new formulation of isosorbide dinitrate oral spray and sublingual nitroglycerin tablets. Am. J. Cardiol. 1990, 65: 43-45.
6. Reisin LH, Candau E and Darawshi A. More rapid relief of pain with isosorbide dinitrate oral spray than with sublingual tablets in elderly patients with angina pectoirs. Am. J Cardiol. 1988, 61: 2-3.
7. Marmor A, Plich M, Blondheim D, Sharir T and Alpert JS. Increased exercise tolerance and reduced duration of ischaemia after isosorbide dinitrate oral spray in angina pectorios. Am. J Cardiol. 1988, 61: 4-6.
8. Jakob M, Retting-Sturmer G and Stepien J. Isosorbide dinitrate solution spray in exer cise-induced angina pectoirs. Drug Invest, 1993, 6: 223-230.
9. Кириченко А.А., Панчук Л.Н. Влияние ингаляционной формы изосорбида динитрата на качество жизни пациентов со стабильной стенокардией. Кардиоваскулярная терапия и профилактика, 2005, 3: 72-76.
Review
For citations:
Kirichenko AA. Efficacy of Isoket inhalation in patients with angina pectoris. Meditsinskiy sovet = Medical Council. 2015;(4):58-61. (In Russ.) https://doi.org/10.21518/2079-701X-2015-4-58-61
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