PREGNANCY PLANNING. VITAMIN D DEFICIT – INFERTILITY, CORRECTION OF VITAMIN D DEFICIT
https://doi.org/10.21518/2079-701X-2017-2-46-47
Abstract
Study objective. To study the efficacy of the drugs vitamin D at the stage of planning of pregnancy in women with infertility of various etiologies, according to domestic and foreign literature.
Materials and methods. We conducted a search of the literature sources by the keywords “vitamin D”, “infertility”, “pregravid preparation” in domestic and foreign databases: elibrary, Medline/PubMed, Embase, CINAHL. 23 sources were selected.
Study results. Vitamin D plays an important role in the regulation of the menstrual cycle and the reproductive health of women. The prevalence of vitamin D deficiency among women with infertility of various etiologies reaches 69%. It is vital to achieve an adequate level of vitamin D in a woman’s body and to prevent its deficiency.
Conclusion. For all women with infertility at the stage of preparation it is recommended to conduct assessment of adequacy of vitamin D by determination of 25(OH)D in serum and correction of its deficit to achieve levels of 25(OH)D more than 30 ng/ml.
About the Authors
O. I. Yazykova
Academician Kulakov Scientific Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Russian Federation
Moscow
Russian Federation
Moscow
E. G. Khilkevich
Academician Kulakov Scientific Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Russian Federation
Russian Federation
MD, Prof.,
Moscow
References
1. Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol, 2008, 3(5): 1535-1541.
2. Pérez-López FR, Chedraui P Fernández-Alonso AM. Vitamin D and aging: Beyond calcium and bone metabolism. Maturitas, 2011, 69: 27-36.
3. Alpert PT, Shaikh U. The effects of vitamin D deficiency and insufficiency on the endocrine and paracrine systems. Biol. Res. Nurs., 2007, 9(2): 117-29.
4. Holick MF, Binkley NC, a Bischoff-Ferrari H, Gordon CM, a Hanley D, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab., 2011, 96(7): 1911-30.
5. Калинченко С.Ю., Жиленко М.И., Гусакова Д.А. Витамин D и репродуктивное здоровье женщин. Проблемы репродукции, 2016, 4: 28-36.
6. Dressler N, Chandra A, Aguirre Davila L, Spineli LM, Schippert C, von Versen-Höynck F. BMI and season are associated with vitamin D deficiency in women with impaired fertility: a two-centre analysis, Arch. Gynecol. Obstet., 2016, 293(4): 907-914.
7. Deressa E, Wammer AC, Falch JA, Jahnsen J. Bone metabolism in patients with newly diagnosed caeliac disease, Tidsskr. Nor Laegeforen., 2006, 126: 0807–7096 (Electronic), : 1201–1204.
8. Наими З.М.С., Калинина Е.А., Донников А.Е. Ассоциация уровня витамина D в крови с исходами программ вспомогательных репродуктивных технологий. Акушерство и гинекология, 2016, 8: 93-98.
9. Grundmann M, Von Versen-Höynck F. Vitamin D – roles in women ’ s reproductive health ? Reprod. Biol. Endocrinol., 2011, 25(9): 1-12.
10. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: A systematic review. Fertil. Steril., 2014, 102(2): 460-468.
11. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology, vol. 141, no. 4, : 1317–1324, 2000.
12. Надь Ю.Г. Клиническое значение применения витамина Д при гипогонадизме. Научный альманах, 2015, 10(8): 601-603.
13. Pagliardini L, Vigano’ P, Molgora M, Persico P, Salonia A, Vailati SH, Paffoni A, Somigliana E, Papaleo E, Candiani M. High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction. Nutrients, 2015, 7(12): 9972-84.
14. Al-Jaroudi D, Al-Banyan N, Aljohani NJ, Kaddour O, Al-Tannir M. Vitamin D deficiency among subfertile women: case-control study. Gynecol. Endocrinol., 2016, 32(4): 272-5.
15. Viganò P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, Panina-Bordignon P, Besozzi M, Di Blasio AM. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol., 2006, 36(3): 415-424.
16. Thomson RL, Spedding S, Buckley JD. Vitamin D in the aetiology and management of polycystic ovary syndrome. Clin. Endocrinol. (Oxf)., 2012, 77(3): 343-350.
17. Patra SK, Nasrat H, Goswami B, Jain A. Vitamin D as a predictor of insulin resistance in Polycystic Ovarian Syndrome. Diabetes Metab. Syndr. Clin. Res. Rev., 2012, 6(3): 146-149.
18. ehghani Firouzabadi RD, Aflatoonian A, Modarresi S, Sekhavat L, MohammadTaheri S. Therapeutic effects of calcium & vitamin D supplementation in women with PCOS. Complement. Ther. Clin. Pract., 2012, 18(2): 85-88.
19. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J, Taylor H. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol. Endocrinol., 2012, 28(12): 965-8.
20. Polyzos NP, Anckaert E, Guzman L, Schiettecatte J, Van Landuyt L, Camus M, Smitz J, Tournaye H. Vita min D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum. Reprod., 2014, 29(9): 2032-2040.
21. Paffoni A, Ferrari S, Viganò P, Pagliardini L, Papaleo E, Candiani M, Tirelli A, Fedele L, Somigliana E. Vitamin D deficiency and infertility: Insights from in vitro fertilization cycles. J. Clin. Endocrinol. Metab., 2014, 99(11): E2372-E2376.
22. Paffoni A, Somigliana E, Vigano P, Benaglia L, Cardellicchio L, Pagliardini L, Papaleo E, Candiani M, Fedele L. Vitamin D Status in Women With Uterine Leiomyomas. J Clin Endocrinol Metab., 2013 Aug, 98(8): 1374-8.
23. Громова О.А., Лиманова О.А., Торшин И.Ю., Керимкулова Н.В., Рудаков Н.В. Дозозависимость защитных эффектов фолиевой кислоты в прегравидарный период, во время беременности и в период лактации. РМЖ, 2014, 1: 27-34.
Review
For citations:
Yazykova OI, Khilkevich EG. PREGNANCY PLANNING. VITAMIN D DEFICIT – INFERTILITY, CORRECTION OF VITAMIN D DEFICIT. Meditsinskiy sovet = Medical Council. 2017;(2):46-47. (In Russ.) https://doi.org/10.21518/2079-701X-2017-2-46-47
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