TREATMENT OF DIABETIC DISTAL POLYNEUROPATHY WITH ACTOVEGIN® IN TYPE 2 DIABETIC PATIENTS.
https://doi.org/10.21518/2079-701X-2017-11-162-164
Abstract
The possibilities of treatment of diabetic polyneuropathy with Actovegin® are discussed in this publication. In the multicenter, randomized, double-blind trial 567 patients with type 2 diabetes received 20 intravenous infusions of 20% solution of Actovegin® or placebo followed by 1800 mg of Actovegin® in tablets or placebo for 140 days. The effectiveness was assessed by changes of Total Symptom Score and vibration perception as primary outcomes, neuropathy impaired score of the lower limbs (NIS-LL) and quality of life as secondary end points. Treatment with Actovegin resulted in significant improvement in TSS (p = 0,0003), sensory component of NIS-LL (p = 0,021), improvement of vibration perception (р = 0,08) and mental domain of quality of life. Thus, treatment of diabetic distal polyneuropathy with Actovegin® in type 2 diabetic patients improves different functions of peripheral nervs.
About the Authors
E. U. Komelyagina
Endocrinology Dispensery of the Department of health of Moscow city
Russian Federation
Russian Federation
M. B. Antsiferov
Endocrinology Dispensery of the Department of health of Moscow city
Russian Federation
Russian Federation
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For citations:
Komelyagina EU, Antsiferov MB. TREATMENT OF DIABETIC DISTAL POLYNEUROPATHY WITH ACTOVEGIN® IN TYPE 2 DIABETIC PATIENTS. Meditsinskiy sovet = Medical Council. 2017;(11):162-164. (In Russ.) https://doi.org/10.21518/2079-701X-2017-11-162-164
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