Aflibercept: side effects in focus
https://doi.org/10.21518/2079-701X-2018-10-18-26
Abstract
A new anti-angiogenic drug aflibercept has been authorized as a second-line therapy in patients with metastatic colon cancer. The use of this drug as part of FOLFIRI regimen significantly reduces the risk of disease progression (RR = 0.758, p = 0.00007). At the same time, the additional use of aflibercept in the VELOUR study led to the development of side effects of 3-4 degrees of severity in 83.5% of patients. In this case, the use of aflibercept in combination with FOLFIRI is not only associated with complications that are typical for anti-angiogenic drugs, but also with a high percentage of cases of diarrhea and neutropenia. In this regard, the oncologist should understand the pathogenesis, the methods for prevention and treatment of complications associated with the use of aflibercept. These particular aspects are highlighted is this review.
About the Author
M. Yu. Fedyanin
N.N.Blokhin National Medical Research Cancer Centre of Oncology, Federal State Budgetary Institution of the Ministry of Health of Russia
Russian Federation
Russian Federation
MD
Moscow
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Review
For citations:
Fedyanin MY. Aflibercept: side effects in focus. Meditsinskiy sovet = Medical Council. 2018;(10):18-26. (In Russ.) https://doi.org/10.21518/2079-701X-2018-10-18-26
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