Optimization of allergen-specific immunotherapy in patients with seasonal allergic rhinitis and secondary immunodeficiency syndrome

Abstract

Seasonal allergic rhinitis (SAR) remains an important medical and social problem, the importance of which is determined by the steady growth of morbidity, the expansion of the spectrum of pollen sensitisation, the development of complications in the form of otitis, sinusitis, eustachitis, and often low efficiency of standard therapy. One of the reasons for the complication of allergic diseases in general and SAR in particular is the combination of allergy and secondary immune deficiency syndrome (SID). In order to form an understanding of the possibilities of allergen-specific immunotherapy (ASIT) optimization, an analysis of the clinical, immunological and allergic status of patients suffering from SAR with concomitant SID syndrome who received two ASIT courses. All patients (40 people aged 18-60 years) were divided into two groups: those receiving only SIT (20 people) and those receiving gamma-D-glutamyl triptofan (GDGT) immunomodulator treatment (20 people) in addition to standard therapy. The results of the study clearly indicate a sufficiently high therapeutic efficacy of the used approach of combination of preventive immunocorrection and ASIT, which consists in a reliable reduction of morbidity and duration of ARVI episodes, more significant effectiveness of ASIT. The basis of the positive effect of preventive therapy of GDGT is the restoration of functional parameters of the immune system.