Reproductive outcomes following surgical removal of uterine fibroids
https://doi.org/10.21518/2079-701X-2019-7-110-118
Abstract
The cohort prospective comparative study investigated the efficacy of mifepristone use in patients after surgical treatment of uterine myoma. It was shown that the use of mifepristone at a dose of 50 mg/day in a continuous mode for 3 months after surgical treatment for proliferating uterine myoma led to the absence of recurrences of the disease for 2 years after the drug withdrawal. The use of mifepristone after embolization of uterine arteries allowed to significantly reduce the size of the node by 25% during 12 months and by 50% (p<0.05) after 24 months. Complex treatment of uterine myoma, including myomectomy and drug therapy with mifepristone, allowed to realize reproductive function in 46% of patients, and delivery through the natural birth canal occurred in 24% of patients.
About the Authors
A. E. Mitichkin
State Budgetary Institution of Healthcare of the City of Moscow «City Clinical Hospital named after F.I. Inozemtsev of the Department of Healthcare of the City of Moscow».
Russian Federation
Russian Federation
Mitichkin Aleksandr Yevgenyevich – Dr. of Sci. (Med), Professor, Chief Doctor.
105187, Russia, Moscow, Fortunatovskaya St., 1.
Yu. E. Dobrokhotova
Federal State Budgetary Educational Institution of Higher Education «Russian National Research Medical University named after N.I. Pirogov» of the Ministry of Health of the Russian Federation.
Russian Federation
Russian Federation
Dobrokhotova Yulia Eduardovna – Dr. of Sci. (Med), Professor, Head of the
Department of Obstetrics and Gynecology of the Faculty of Medicine.
117997, Russia, Moscow, Ostrovityanova St., 1.
N. Yu. Ivannikov
State Budgetary Institution of Healthcare of the City of Moscow «City Clinical Hospital named after F.I. Inozemtsev of the Department of Healthcare of the City of Moscow»; Federal State Budgetary Educational Institution of Higher Education «Russian National Research Medical University named after N.I. Pirogov» of the Ministry of Health of the Russian Federation.
Russian Federation
Russian Federation
Ivannikov Nikolay Yurievich – Candidate of Medical Sciences, Associate Professor of
the Department of Obstetrics and Gynecology of the Faculty of Medicine; Deputy Chief Doctor or Obstetrical and Gynecological Care.
105187, Russia, Moscow, Fortunatovskaya St., 1.
117997, Russia, Moscow, Ostrovityanova St., 1.
V. I. Dimitrova
State Budgetary Institution of Healthcare of the City of Moscow «City Clinical Hospital named after F.I. Inozemtsev of the Department of Healthcare of the City of Moscow».
Russian Federation
Russian Federation
Dimitrova Valentina Ivanovna – Candidate of Medical Sciences, Head of the Gynecological Department.
105187, Russia, Moscow, Fortunatovskaya St., 1.
O. A. Slyusareva
State Budgetary Institution of Healthcare of the City of Moscow «City Clinical Hospital named after F.I. Inozemtsev of the Department of Healthcare of the City of Moscow».
Russian Federation
Russian Federation
Slyusareva Olga Alexandrovna– Candidate of Medical Sciences, obstetrician-gynecologist.
105187, Russia, Moscow, Fortunatovskaya St., 1.
S. A. Khlynova
Federal State Budgetary Educational Institution of Higher Education «Russian National Research Medical University named after N.I. Pirogov» of the Ministry of Health of the Russian Federation.
Russian Federation
Russian Federation
Khlynova Svetlana Anatolievna – Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology of the Medical Faculty.
117997, Russia, Moscow, Ostrovityanova St., 1.
V. A. Lyubeshkina
State Budgetary Institution of Healthcare of the City of Moscow «City Clinical Hospital named after F.I. Inozemtsev of the Department of Healthcare of the City of Moscow».
Russian Federation
Russian Federation
Lyubeshkina Vera Aleksandrovna – obstetrician-gynecologist.
105187, Russia, Moscow, Fortunatovskaya St., 1.
T. G. Mustafaeva
State Budgetary Institution of Healthcare of the City of Moscow «City Clinical Hospital named after F.I. Inozemtsev of the Department of Healthcare of the City of Moscow».
Russian Federation
Russian Federation
Mustafaeva Tatyana Gennadyevna – obstetrician-gynaecologist.
105187, Russia, Moscow, Fortunatovskaya St., 1.
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Review
For citations:
Mitichkin AE, Dobrokhotova YE, Ivannikov NY, Dimitrova VI, Slyusareva OA, Khlynova SA, Lyubeshkina VA, Mustafaeva TG. Reproductive outcomes following surgical removal of uterine fibroids. Meditsinskiy sovet = Medical Council. 2019;(7):110-118. (In Russ.) https://doi.org/10.21518/2079-701X-2019-7-110-118
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