Vitamin D and acute respiratory infections: prevention or treatment?
https://doi.org/10.21518/2079-701X-2019-6-116-124
Abstract
Vitamin D has a large number of biological effects due to the effect on the vitamin D receptor, which is present in most tissues in the body. The possible role of vitamin D in infections is explained by its effect on the mechanisms of the innate and acquired immune response. Suppression of the inflammatory response is also an important effect of vitamin D. Many scientists strongly believe that vitamin D deficiency is among the so-called «seasonal stimulators» of acute respiratory viral infections (ARVI), the potential for the prophylactic and therapeutic use of vitamin D in the season of ARVI and influenza is of particular interest. 25-hydroxycalciferol-stimulated production of antimicrobial peptides, such as defensin and cathelicidin is the most important fact proving the possible protective role of vitamin D in influenza and other acute respiratory infections. These endogenous peptides have a direct action, destroying not only microbial pathogens, but also viruses, including the influenza virus.
About the Authors
N. B. Lazareva
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Lazareva Nataliya Borisovna – Dr. of Sci. (Med.), Professor of the Chair for Clinical Pharmacology and Propaedeutics of Internal Diseases
8, Trubetskaya Street, Moscow, 119991, p. 2
E. V. Rebrova
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Rebrova Ekaterina Vladislavovna – Cand. of Sci. (Med.), Associate Professor of the Chair for Clinical Pharmacology and Propaedeutics of Internal Diseases
8, Trubetskaya Street, Moscow, 119991, p. 2
L. R. Panteleeva
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Panteleeva Lola Remindzhanovna – Cand. of Sci. (Med.), Associate Professor of the Chair for Clinical Pharmacology and Propaedeutics of Internal Diseases
8, Trubetskaya Street, Moscow, 119991, p. 2
A. Yu. Ryazanova
Federal State Budgetary Educational Institution of Higher Education «Volgograd State Medical University» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Ryazanova Anastasia Yuryevna – Associate Professor of the Chair for Clinical Pharmacology and Intensive Therapy with a course of Clinical Pharmacology of Faculty of Continuing Medical Education, Clinical Allergology of Faculty of Continuing Medical Education
400131, Volgograd, pl. Pavshikh Bortsov, 1
D. A. Bondarenko
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Bondarenko Dmitri Alexandrovich – a student of the Chair for Clinical Pharmacology and Propaedeutics of Internal Diseases
8, Trubetskaya Street, Moscow, 119991, p. 2
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For citations:
Lazareva NB, Rebrova EV, Panteleeva LR, Ryazanova AY, Bondarenko DA. Vitamin D and acute respiratory infections: prevention or treatment? Meditsinskiy sovet = Medical Council. 2019;(6):116-124. (In Russ.) https://doi.org/10.21518/2079-701X-2019-6-116-124
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