Possibilities of sodium picosulfate application in constipation pharmacotherapy in functional intestinal disorders
https://doi.org/10.21518/2079-701X-2019-3-92-97
Abstract
Constipation, which is currently one of the global problems of mankind, requires modern approaches to its pharmacological correction. Constipation that occurs in the absence of organic digestive pathology is in most cases considered a symptom of functional constipation or irritable bowel syndrome, the diagnosis of which is based on the compliance of the patient’s complaints and anamnestic data with the Rome IV criteria for the diagnosis of these functional disorders. Regulax Picosulphate, an intravenous droplet, is a modern laxative drug with a possibility of precise and easy dosing that does not have a local irritant effect on the gastric and duodenal mucous membranes; the efficacy and safety of this drug has been proven in controlled clinical trials.
About the Authors
V. N. Drozdov
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Dr. of Sci. (Med), Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases,
8, Trubetskaya Street, Moscow, 119991, p. 2
K. I. Karnouh
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Clinical resident of the Department of Clinical Pharma co logy and Propaedeutics of Internal Diseases,
8, Trubetskaya Street, Moscow, 119991, p. 2
S. Y. Serebrova
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University);
Federal State Budgetary Institution «Scientific Center of Expertise of Medical Devices» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci. (Med), Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases, 8, Trubetskaya street, Moscow, 119991, p. 2;
127051, Moscow, Petrovsky Boulevard, 8, p.
I. A. Komissarenko
Federal State Budgetary Educational Institution of the Higher Education «Moscow State University of Medicine and Dentistry named after A.I. Yevdokimov» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci. (Med), Professor of the Department of Polyclinic Therapy,
127473, Moscow, 20, Delegateskaya St
A. K. Starodubtsev
Federal State Autonomous Educational Institution of Higher Education First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Dr. of Sci. (Med), Professor of the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases,
8, Trubetskaya Street, Moscow, 119991, p. 2
References
1. Lembo A.J. Constipation. In: Sleisenger and Fordtran’s Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Ed. by M. Feldman, L.S. Friedman, L.J. Brandt. 10th ed. 2015.
2. Suares N.C., Ford A.C. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and metaanalysis. Am J Gastroenterol. 2011;10 (9):1582–91.
3. Prilepskaya S.I., Parfenov A.I., Lazebnik L.B. Prevalence and risk factors of constipation in the adult population of Moscow according to the data of the population study «MUZA». Experimental and clinical gastroenterology [Jeksperim. i klin. Gastrojenterologija]. 2011;3:68–73. (In Russ.)
4. Belsey J., Greenfield S., Candy D., Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther. 2010;31:938–49.
5. Самсонов А.А., Кучерявый Ю.А., Андреев Д.Н. Хронический запор: проблемы терапии. Врач. 2011;4:24–9. [Samsonov A.A., Kucheryavy Yu.A., Andreev D.N. Chronic constipation: problems of therapy. Doctor [Vrach]. 2011;4:24–9.] (In Russ.)
6. Lacy B.E., Mearin F., Chang L. et al. Bowel Disorders. Gastroenterology. 2016;150:1393–1407.
7. Baranskaya E.K. Irritated bowel syndrome: diagnostics and treatment. Dyspepsia. Attachment [Dispepsija. Pril.]. 2002:31-36. (In Russ.)
8. Cheremushkin S.V., Kucheryavy Y.A. Principles of treatment of chronic constipation. Medical advice [Med. Sovet]. 2012;9:52–7. (In Russ.)
9. Kazyulin A.N., Kucheryavy Y.A. Practical and clinical aspects of clinical constipation syndrome. Methodical guidelines for physicians. М., 2005. (In Russ.)
10. Chung B.D., Parekh U., Sellin J.H. Effect of increased fluid intake on stool output in normal healthy volunteers. J. Clin. Gastroenterol. 1999;28:29–32.
11. Ivashkin V.T., Maev I.V., Sheptulin A.A. and others. Clinical recommendations of the Russian Gastroenterological Association for the diagnosis and treatment of adult patients with chronic constipation. Rus. journal of gastroenterology, hepatology, coloproctology [Ros. zhurn. gastrojenterologii, gepatologii, koloproktologii]. 2017;27(3):75–83. (In Russ.)
12. Zaychikova M.S. Laxatives. Monitoring of pharmacy sales. New pharmacy [Novaja apteka]. 2015;1-7:16-18. (In Russ.)
13. Farack U.M., Gruber E., Loeschke K. The influence of bisacodyl and deacetylbisacodyl on mucus secretion, mucus synthesis and electrolyte movements in the rat colon in vivo. Eur J Parmacol. 1985;117:215–22.
14. Kienzle-Horn S., Vix J.M., Schuijt C., et al. Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation. Curr Med Res Opin. 2007;23: 691–99.
15. Mueller-Lissner S., Kamm M.A., Wald A., et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol. 2010;105(4):897–903.
16. Friedrich C., Richter E., Trommeshauser D., et al. Absence of excretion of the active moiety of Bisacodyl and Sodium Picosulfate into human breast milk: an open-label, parallelgroup, multiple-doses study in healthy lactating women. Drug Metab Pharmacokinet. 2011;26(5):458–64.
Review
For citations:
Drozdov VN, Karnouh KI, Serebrova SY, Komissarenko IA, Starodubtsev AK. Possibilities of sodium picosulfate application in constipation pharmacotherapy in functional intestinal disorders. Meditsinskiy sovet = Medical Council. 2019;(3):92-97. (In Russ.) https://doi.org/10.21518/2079-701X-2019-3-92-97
Views:
946
Email this article 