Prevalence of endothelial dysfunction and dyslipidemia in patients with chronic rheumatic heart disease
https://doi.org/10.21518/2079-701X-2019-12-14-18
Abstract
The article presents the results of the study of endothelial function (EF) and lipid spectrum in 114 patients with chronic rheumatic heart disease (CRHD) during 5 years. The average age of the patients was 58.68 ±0.47 years; 18 men (15.8%) and 96 women (84.2%). Angioscan-01 apparatus was used to study EF. The occlusion index amplitude was reduced in all patients with CRHD. The minimum values of EF in the system of small resistive arteries were in patients with I functional class (FQ of chronic heart failure: 1.39 ± 0.07, and the maximum with II FO 1.73 ± 0.16. In the system of large conductive arteries, on the contrary, more pronounced changes are noted in II FC (-10,36 ± 2,07) and III FC (-8,94 ± 2,23), and the smallest in I FC (1,46 ± 6,69). The augmentation index showed high rigidity of the vascular wall and tended to decrease from the group with FC I (15,65 ± 2,05%) to the group with FC III (13,06 ± 2,35), but the difference was statistically insignificant. The age of the vascular wall varied significantly from 62.88 ± 3.46 years (I FC) to 70.71 ± 2.74 years (III FC). The values of total cholesterol (5.14 ± 0.12 and 5.48 ± 0.20 mm/l, after 5 years) and low-density lipoproteins (2.75 ± 0.09 and 2.72 ± 0.12 mm/l, after 5 years) did not change. Thus, patients with СRHD have EF disorders both in large conductive arteries (phase shift -6.64 ± 1.95 and -4.42 ± 2.29 ms, after 5 years) and in the microcirculation system (occlusion index 1.40 ± 0.09 and 1.46 ± 0.08, after 5 years) without significant dynamics during 5 years of observation.
About the Author
V. S. Petrov
Federal State Budgetary Educational Institution of Higher Education «Ryazan State Medical University named after Academician I.P. Pavlov» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Petrov Vadim Sergeevich - Cand. of Sci. (Med), Associate Professor of the Department of Hospital Therapy.
390026, Ryazan, Vysokovoltnaya St., 9; tel: +7(910) 642-58-96
References
1. Filippov E.V, Petrov VS., Okorokov VG. IHD, myocardial infarction and stroke. Prevalence, association, impact on outcome (according to the research Meridian-RO). Medicinskjisovet. 2015;8:14-21. (In Russ.)
2. Yakushin S.S., Filippov E.V. Value assessment of endothelial function at the population level (according to the research Meridian-RO). Nauka molodykh (Ernditio Juvenium). 2013;3:48-55. (In Russ.)
3. Katz S.D., Hryniewicz K., Hriljac I., Balidemaj K., Dimayuga C., Hudaihed A. et al. Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation. 2005;111:310-4.
4. Kalinin R.E., Suchkov I.A., Mzha-vanadze N.D., Povarov V.O. Endotelial dysfunction in patients with cardiac implantable electronic devices (literature review). Nauka molodykh (Eruditio Juvenium). 2016;3:84-92. (In Russ.)
5. Petrov V.S. Result of 5-year observation for patients with rheumatic heart disease. \P Pavlov Medical Biological Herald. 2015;3:83-7. (in Russ.)
6. Rossi A., Faggiano P., Amado A.E., Cicoira M., Bonapace S., Franceschini L. et al. Mitral and aortic valve sclerosis calcification and carotid atherosclerosis: results from 1065 patients. Heart Vessels. 2014;29(6):776-83.
7. Novo G., Guarneri F.P., Ferro G., Russo R., Fattouch K., Novo S. Association between asymptomatic carotid atherosclerosis and degenerative aortic stenosis .Atherosclerosis. 2012;2 23(2) :519-22.
8. Zhernakova Yu.V., Kaveshnikov V.S., Serebriakova V.N.,Trubacheva i.A., Oshepkova E.V., Balahonova T.V. et al. The prevalence of carotid atherosclerosis in spontaneous populations in Tomsk. Systemic Hypertension. 2014;4:37-42. (In Russ.)
9. Emren Z.Y., Emren S.V., Kiligaslan B., Solmaz FI., Susam I., Sayin A. et al. Evaluation of the prevalence of coronary artery disease in patients with valvular heart disease.Journal of Cardiothoracic Surgery. 2014;9:153.
10. Bobrowska B.,Zasada W.,Surdacki A., Rakowski I, Kleczynski R, Swierszcz J. et al. Predictors of Coronary and Carotid Atherosclerosis in Patients with Severe Degenerative Aortic Stenosis. IntJ Med Sci. 2013;10:1361-66. doi: 10.7150/ijms.6389.
11. Sabbagh A.El., Nishimura R.A. Clinical Conundrum of Coronary Artery Disease and Aortic Valve Stenosis. Journal of the American Head: Association. 2017;6:e005593. doi: 10.1161/JAFIA.l17.005593.
12. Paradis J.M., Fried J., Nazif T., Kirtane A., Flarjai K-, Khalique O. et al. Aortic stenosis and coronary artery disease: What do we know? What don’t we know? A comprehensive review of the literature with proposed treatment algorithms. European Heart Journal. 2014;35:2069-2082.
13. Parfenov A.S. Early diagnosis of cardiovascular diseases using hardware-software complex the Angio-scan-01. Policlinika. 2012;2:1-5. (in Russ.)
14. Kosheleva N.A., Rebrov А.Р. Endothelial dysfunction in patients with chronic heart failure. Vestniksovremennoi klinicheskoi mediciny. 2009;1:9-14. (In Russ.)
15. Fischer D., Rossa S., Landmesser U., Spiekermann S., Engberding N., Hornig B. et al. Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization cardiac transplantation, or death. European Head Journal. 2005;26:65-69.
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For citations:
Petrov VS. Prevalence of endothelial dysfunction and dyslipidemia in patients with chronic rheumatic heart disease. Meditsinskiy sovet = Medical Council. 2019;(12):14-18. (In Russ.) https://doi.org/10.21518/2079-701X-2019-12-14-18
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