Diuretics in the treatment of patients with arterial hypertension: results of the DOVERIE comparative study
https://doi.org/10.21518/2079-701X-2014-12-18-24
Abstract
The use of thiazide, thiazide-like and loop diuretics in patients with hypertension is widely discussed. So far, there have been few direct comparative studies of different classes of diuretics in hypertension. The randomized, comparative, open DOVERIE study (efficacy and safety of Diuver in combination therapy in hypertensive patients in outpatient setting) found that the antihypertensive effects and safety of torasemide and indapamide are not significantly different. Adding torasemide either to monotherapy with ACEI/ARB II or as substitute for hydrochlorothiazide in combination therapy with ACEI/ARB II + HCTZ resulted in a further significant decrease in blood pressure and allowed to reach target BP in a majority of patients. Therapy with torasemide was not associated with any increase in heart rate, significant changes in potassium levels, uric acid and glucose.
About the Authors
OP Shevchenko
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
EE Averin
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
VA Vygodin
National Research Center for Preventive Medicine, Moscow
Russian Federation
Russian Federation
References
1. Горбунов В.М., Оганов Р.Г. Торасемид - петлевой диуретик с особыми свойствами. Кардиоваскулярная терапия и проф., 2005, 5 (5).
2. Сидоренко Б.А., Преображенский Д.В., Батыралиев ТА. и др. Место диуретиков в лечении хронической сердечной недостаточности. Часть I Кардиология, 2005, 8: 76-83.
3. Киношенко Е.И. Ковалева Е.А., Нудьга А.Н. и др. Петлевые диуретики и артериальная гипертония. Медицина неотложных состояний, 2011, 7: 98-100.
4. Roca-Cusachs A et al. Clinical Effects of Torasemide Prolonged Release in Mild-to-Moderate Hypertension: A Randomized Noninferiority Trial Versus Torasemide Immediate Release. Cardiovasc Ther., 2008, 26(2): 91-100.
5. Coca A. Effect of torasemide in monotherapy or associated to other antihypertensive drugs on pulse pressure in essential hypertension. American Journal of Hypertension, 15.
6. Spannbrucker N, Achhammer I, Metz P, Glocke M. Comparative study on the hypertensive efficacy of torasemide and indapamide in patients with essential hypertention. Drug Res, 1988; 38 (1): 190-193.
7. Neugebauer G, Besenfelder E, van M llendorf E. Pharmacokinetics and metabolism of torasemide in man. Drug Res, 1988, 38(1): 164-166.
8. Brater DC, Leinfelder J, Anderson SA. Clinical pharmacology of torasemide, a new loop diuretic. Clin Pharmacol Ther, 1987, 42: 187-192.
9. Bоelke T, Achhammer I. Torasemide: review of its pharmacology and therapeutic use. Drugs of today, 1994, 8: 1-28.
10. Reyes AJ. Effects of diuretics on outputs and flows of urine and urinary sodium in healthy subjects. Drugs, 1991, 41(3): 35-39.
11. Achhammer I, Metz P. Low dose loop diuretics in essential hypertension: Experience with torasemide. Drugs, 1991, 41(3): 80-91.
12. Porcellati C, Verdecchia P, Schillaci G et al. La torasemide, nuovo diuretico del'ansa, nell trattamento dell'ipertensione arteriosa: Studio controlla to in doppla cecita. BasRazion Terapia, 1990, 20: 407-410.
13. Baumgart P, Walger P, von Eiff M, Achhammer I. Long-term efficacy and tolerance of torasemide in hypertension. Progress in pharmacology and Clinical Pharmacology, Gustav-Fischer-Verlag: Stuttgart 1990, 8: 169-181.
14. Spannbrucker N, Achhammer I, Metz P, Glocke M. Comparative study on the hypertensive efficacy of torasemide and indapamide in patients with essential hypertension. Drug Res, 1988, 38(1): 190-193.
15. Reyes AJ, Chiesa PD, Santucci MR et al. Hydrochlorothiazide versus a nondiuretic dose of torasemide as once daily antihypertensive monopharmaco-therapy in elderly patients; randomized and double-blind study. Progress in Pharmacology and Clinical Pharmacology, Gustav-Fischer-Verlag: Stuttgart 1990, 8: 183-209.
16. Boelke T, Piesche L Influence of 2,5-5 mg torasemide o.d. versus 25-50 mg HCTZ/50-100 triamterene o.d. on serum parameters in elderly patients with mild to moderate hypertension. Diuretics IV: Chemistry, Pharmacology and clinical Applications, Excerpta Medica: Amsterdam 1993, 279-82.
17. Achhammer I, Eberhard R Comparison of serum potassium levels during long-term treatment of hypertension patients with 2,5 mg torasemide o.d. or 50 mg triamterene/25 mg hydrochlorothi-azide o.d. Progress in Pharmacology and Clinical Pharmacology, Gustav-Fischer-Verlag: Stuttgart 1990, 8: 211-220.
18. Baumgart P. Torasemide in comparison with thiazides in the treatment of hypertension. Cardiovasc Drugs Ther., 1993, 7(1): 63-68.
19. Spannbrucker N, Achhammer I, Metz P, Glocke M. Comparative study on the hypertensive efficacy of torasemide and indapamide in patients with essential hypertension. Drug Res, 1988, 38(1): 190-193.
20. Reyes AJ, Chiesa PD, Santucci MR et al. Hydrochlorothiazide versus a nondiuretic dose of torasemide as once daily antihypertensive monopharmaco-therapy in elderly patients; randomized and double-blind study. Progress in Pharmacology and Clinical Pharmacology, Gustav-Fischer-Verlag: Stuttgart 1990, 8: 183-209.
21. Boelke T, Piesche L Influence of 2,5-5 mg torasemide o.d. versus 25-50 mg HCTZ/50-100 triamterene o.d. on serum parameters in elderly patients with mild to moderate hypertension. Diuretics IV: Chemistry, Pharmacology and clinical Applications, Excerpta Medica: Amsterdam 1993, 279-82.
22. Achhammer I, Eberhard R Comparison of serum potassium levels during long-term treatment of hypertension patients with 2,5 mg torasemide o.d. or 50 mg triamterene/25 mg hydrochlorothi-azide o.d. Progress in Pharmacology and Clinical Pharmacology, Gustav-Fischer-Verlag: Stuttgart 1990, 8: 211-220.
23. Baumgart P. Torasemide in comparison with thiazides in the treatment of hypertension. Cardiovasc Drugs Ther., 1993, 7(1): 63-68.
Review
For citations:
Shevchenko O, Averin E, Vygodin V. Diuretics in the treatment of patients with arterial hypertension: results of the DOVERIE comparative study. Meditsinskiy sovet = Medical Council. 2014;(12):18-24. (In Russ.) https://doi.org/10.21518/2079-701X-2014-12-18-24
Views:
1140
Email this article 