Clinical application of mineralocorticoid receptor antagonists in chronic heart failure
https://doi.org/10.21518/2079-701X-2014-12-70-80
Abstract
The review of literature discusses pathogenetic aspects of chronic heart failure and post-infarction remodelling in the heart. The focus is on the role of neurohormonal activation and the important role of aldosterone. There is data on the efficacy and safety of drugs belonging to mineralocorticoid receptor antagonists obtained in the course of randomized clinical trials. Different aspects of clinical application of the selective aldosterone receptor blocker eplerenone are emphasized. The application in clinical practice is supported by research findings.
About the Author
MG Bubnova
National Research Center for Preventive Medicine, Moscow
Russian Federation
Russian Federation
References
1. Инструкция по медицинскому применению препарате Инспра". Л CP-0MQ52/10-070510.
2. Pitt В. Remrne W, Zannad F, et aL Epierenone. a selective aldosterone blacker, in potiens with left ventricular dysfunction after myocardial Infarction. N Engl J Med 2003; 34& 1309-2.
Review
For citations:
Bubnova M. Clinical application of mineralocorticoid receptor antagonists in chronic heart failure. Meditsinskiy sovet = Medical Council. 2014;(12):70-80. (In Russ.) https://doi.org/10.21518/2079-701X-2014-12-70-80
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