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Aging changes in skin: causes and effects

https://doi.org/10.21518/ms2023-027

Abstract

Aging, and in particular aging changes in skin, are increasingly giving cause for concern to the mankind, especially given the fact that the life expectancy is extending. Skin aging is not only a problem that concerns skin sagginess, but rather it is a complex problem caused by many factors, from immune deficiency to the lifestyle, which affects both the maintenance of the skin’s barrier function and the well-being of the stem cells that support the organ. The structure and amount of lipids in the stratum corneum changes over time, the epidermis becomes thinner, which leads to decreased barrier function of the skin. These changes also cause increased loss of transepidermal fluid. The aging-associated processes in the dermis lead to a loss of skin elasticity and a decrease in hydration. The increased levels of cytokines and histamine in the skin can cause itching and scratching, which will lead to a further increase in skin inflammation. All this can be manifested by severe xerosis, peeling and other unpleasant symptoms. It is impossible to defeat aging, but to minimize its manifestations is an achievable goal. Our experience allows us to recommend care products with pronounced nutritional and moisturizing properties, which contain panthenol, prebiotics and probiotics, sodium hyaluronate and a natural complex of glycoceramides, cholesterol and phospholipids. Panthenol has a regenerating and softening effect, nourishes and relieves irritation, contributes to the increasing strength of collagen fibres. Sodium hyaluronate is responsible for deep hydration of the skin, improving its tone and elasticity. The ceramide complex compensates for the lack of lipids and helps to retain moisture in the stratum corneum. Regular care helps to minimize xerosis, itching, skin tightness and maintain quality of life in aging patients.

About the Authors

A. L. Piruzyan
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS
Russian Federation

Anastas L. Piruzyan, Dr. Sci. (Med.), Professor, Leading Researcher

30, Srednyaya Kalitnikovskaya St., Moscow, 109029, Russia 



D. R. Mildzikhova
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS
Russian Federation

Dzerassa R. Mildzikhova, Junior Researcher, Cosmetologist, Dermatologist 

30, Srednyaya Kalitnikovskaya St., Moscow, 109029, Russia 



L. R. Sakaniya
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS; Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology
Russian Federation

Luiza R. Sakaniya, Junior Researcher, Dermatovenerologist;  Dermatovenerologist, Cosmetologist, Trichologist

30, Srednyaya Kalitnikovskaya St., Moscow, 109029, Russia 

20, Seleznevskaya St., Moscow, 127473, Russia 



I. M. Korsunskaya
Center for Theoretical Problems of Physico-Chemical Pharmacology RAS
Russian Federation

Irina M. Korsunskaya, Dr. Sci. (Med.), Professor, Head of Laboratory 

30, Srednyaya Kalitnikovskaya St., Moscow, 109029, Russia 



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Review

For citations:


Piruzyan AL, Mildzikhova DR, Sakaniya LR, Korsunskaya IM. Aging changes in skin: causes and effects. Meditsinskiy sovet = Medical Council. 2023;(2):8-12. (In Russ.) https://doi.org/10.21518/ms2023-027

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ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)