Immunological aspects of the course of the toxic-allergic form of chronic tonsillitis against the background of the use of a combined herbal medicinal product

Introduction. To this day, chronic tonsillitis is considered an urgent research issue in otorhinolaryngological practice, as it is characterized by a complex course and the risk of complications.

Aim. To determine the role of immunity in children with chronic tonsillitis of a toxic-allergic form against the background of the use of a complex herbal preparation.

Materials and methods. The study included 38 children with chronic toxic-allergic tonsillitis, who, depending on the type of treatment, were divided into 2 groups. Group 1 (n = 18) – standard treatment was performed. Group 2 (n = 20 – traditional therapy + combined herbal medicinal product Tonsilgon® N. The research methods included biochemical methods – assessment of the degree of intoxication, activity of lipid peroxidation processes, liver function, intensification of the immune system, intensification of the hemostasis system.

Results. It was found that the development of chronic toxic-allergic tonsillitis is characterized by significant disturbances in the activity of the immune system. An increase in the activity of the pro-inflammatory link of the immune system and depression of the anti-inflammatory component were noted. These changes led to the progression of tonsillitis in the form of endogenous intoxication and oxidative stress, on the one hand, and the development of complications – hepatic depression and hemostatic disorders. The ineffectiveness of traditional therapy in chronic tonsillitis is due to the lack of specific administration complex anti-inflammatory agent, which leads to the resort to surgical intervention. The nature of the above violations was persistent and irreversible against the background of standard treatment, and reversible with complex therapy. The inclusion of complex anti-inflammatory agent from the early stages of the disease led to a decrease in endotoxicosis, lipoperoxidation activity, restoration of immune, hepatic, and hemostatic activity for 10 days.

Conclusion. The immunological component plays an important role in the pathogenetic process of the toxic-allergic form of chronic tonsillitis, requiring the inclusion of a combined herbal medicinal product.

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