Chlamydia and pregnancy: Features of the course and therapy

Chlamydia infection is one of the most common sexually transmitted infections. It is caused by the obligate intracellular bacterium Chlamydia trachomatis, which affects both men and women, but in most cases it is asymptomatic, making timely diagnosis and treatment difficult. The clinical manifestations of chlamydia infection are caused by the pathogen’s tropism for the cylindrical epithelium and its ability to infect the mucous membranes of the urethra, cervical canal, fallopian tubes, endometrium, rectum, oropharynx, and conjunctiva. In women, this condition often leads to cervicitis and urethritis, as well as inflammatory pelvic diseases that can result in tubal-peritoneal infertility. Chlamydia infection is particularly dangerous during pregnancy. It increases the risk of premature birth, amniotic rupture, intrauterine infection, and underweight children. The above substantiates the importance of diagnosing and timely treating chlamydia infection during pregnancy, and the choice of an effective and safe drug during gestation is an urgent issue. The article presents clinical cases of successful use of the antibacterial drug Josafen in obstetric practice in patients with chlamydia infection during pregnancy. This drug has proven to be safe during gestation, well-tolerated, and effective against the pathogen.

Conclusion. Josafen showed high activity against Chlamydia trachomatis, which makes it an effective treatment for urogenital chlamydia during pregnancy, as evidenced by the absence of complications in the anteand postnatal periods.

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