The possibility of feeding children with cancer, taking into account taste sensitivity at the outpatient stage
https://doi.org/10.21518/ms2025-461
Abstract
Rational nutrition plays a crucial role in ensuring the harmonious physical development and cognitive abilities of infants and young children, which is relevant in the context of pediatric oncology, at the outpatient stage. Children with cancer may have problems with feeding and nutritional status. These conditions require monitoring and often immediate intervention, as well as an individual approach to correction. The nutritional difficulties of young children suffering from cancer can be roughly divided into several categories. The first group includes difficulties with eating, such as impaired chewing, dysphagia, and changes in taste sensitivity. The second group is associated with appetite, including hyporexia and hyperrexia, selective appetite, and fear of eating. The third category includes disorders of the gastrointestinal tract and persistent metabolic changes. The fourth category is changes in the structure of nutrition and the formation of vicious eating habits. All these problems can significantly affect the nutritional status of children with cancer, which is reflected in tissue imbalance, lack or excess of body weight and negatively affects their health and quality of life. The causes of these disorders are diverse and can be related to both the direct effects of cancer, as well as side effects of treatment, as well as emotional stress. The development and implementation of personalized nutrition programs that take into account the needs of young children, meet all requirements in terms of composition, safety and taste, as well as those developed on the basis of scientific research, are the most important components of an integrated and multidisciplinary approach to monitoring such patients on an outpatient basis.
About the Authors
T. A. EvdokimovaРоссия
Tatiana A. Evdokimova, Cand. Sci. (Med.), Head of the Department of Clinical Dietetics; Associate Professor of the Department of Dietetics and Nutritionology
1/9, 4th Dobryninsky Lane, Moscow, 119049
2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993
T. A. Kovtun
Россия
Tatiana A. Kovtun, Cand. Sci. (Med.), Assistant of the Department of Dietetics and Nutritionology
2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993
A. Е. Andzhel
Россия
Andrey Е. Andzhel, Deputy Chief Physician for Medical Affairs
1/9, 4th Dobryninsky Lane, Moscow, 119049
Yu. S. Yablokova
Россия
Yuliya S. Yablokova, Dietitian at the Department of Clinical Dietetics
1/9, 4th Dobryninsky Lane, Moscow, 119049
References
1. Баранов АА, Тутельян ВА. Программа оптимизации вскармливания детей первого года жизни в Российской Федерации. М.; 2019. 112 с. Режим доступа: https://nczd.ru/wp-content/uploads/2019/12/Met_rekom_1_god_.pdf.
2. Vashura AY, Kucher MA, Kovtun TA, Alymova YA, Litvinov DV, Zubarovskaya LS, Kulagin AD. The role and relevance of nutritional diagnosis in pediatric oncology. Meditsinskiy Sovet. 2023;(12):99–109. (In Russ.) https://doi.org/10.21518/ms2023-170.
3. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489–495. https://doi.org/10.1016/S1470-2045(10)70218-7.
4. Armstrong GT, Stovall M, Robison LL. Long-term effects of radiation exposure among adult survivors of childhood cancer: results from the childhood cancer survivor study. Radiat Res. 2010;174(6):840–850. https://doi.org/10.1667/RR1903.1.
5. Estado nutricio en pacientes de primer ingreso a hospitalización del Servicio de Hematología del Instituto Nacional de Cancerología [Nutritional status in patients first hospital admissions service hematology National Cancer Institute]. Nutr Hosp. 2013;28(4):1259–1265. (In Spanish) https://doi.org/10.3305/nh.2013.28.4.6484.
6. Withycombe JS, Smith LM, Meza JL, Merkle C, Faulkner MS, Ritter L et al. Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity: a report from the Children’s Oncology Group. Pediatr Blood Cancer. 2015;62(3):434–439. https://doi.org/10.1002/pbc.25316.
7. Polevichenko EV. Nutritional aspects of the treatment of malignant neoplasms in children. RMJ. 2009;22(17):1512–1516. (In Russ.) Available at: https://www.rmj.ru/articles/onkologiya/Nutritivnye_aspekty_lecheniya__zlokachestvennyh_novoobrazovaniy_u_detey.
8. Benson AC, Torode ME, Singh MA. Muscular strength and cardiorespiratory fitness is associated with higher insulin sensitivity in children and adolescents. Int J Pediatr Obes. 2006;1(4):222–231. https://doi.org/10.1080/17477160600962864.
9. Mayorova OA, Rumyantsev AG. Features of the gastrointestinal tract in patients with oncological diseases and during cytostatic therapy (clinical, morphological and functional changes). Russian Pediatric Journal. 2001;(6):44–48. (In Russ.) Available at: http://elib.fesmu.ru/Article.aspx?id=66621.
10. Vashura AYu, Kovtun TA, Lukina SS. Taste disorders in children with hemoblastosis and malignant CNS tumors after treatment. Russian Bulletin of Perinatology and Pediatrics. 2021;66(4):74–80. (In Russ.) https://doi.org/10.21508/1027-4065-2021-66-4-74-80.
11. Argilés JM, Moore-Carrasco R, Fuster G, Busquets S, López-Soriano FJ. Cancer cachexia: the molecular mechanisms. Int J Biochem Cell Biol. 2003;35(4):405–409. https://doi.org/10.1016/s1357-2725(02)00251-0.
12. Damasco-Ávila E, Velasco-Hidalgo L, Zapata-Tarrés M, Cárdenas-Cardos R, Rivera-Luna R. Feeding difficulties and eating disorders in pediatric patients with cancer. Bol Med Hosp Infant Mex. 2019;76(3):113–119. https://doi.org/10.24875/BMHIM.19000072.
13. Zakharova IN, Dmitriyeva YuA, Machneva EB, Kasyanova AN. Physiology of taste perception: the role of genetic and environmental factors in the formation of taste preferences. Russian Bulletin of Perinatology and Pediatrics. 2018;63(4):23–29. (In Russ.) https://doi.org/10.21508/1027-4065-2018-63-4-23-29.
14. Zakharova IN, Dmitrieva YuA, Gordeeva EА. What does the gustatory preferences development in infants depend on? Current Pediatrics. 2012;11(6):69–74. (In Russ.) https://doi.org/10.15690/vsp.v11i6.494.
15. Cohen J, Laing DG, Wilkes FJ, Chan A, Gabriel M, Cohn RJ. Taste and smell dysfunction in childhood cancer survivors. Appetite. 2014;75:135–140. https://doi.org/10.1016/j.appet.2014.01.001.
16. Beaulieu-Gagnon S, Bélanger V, Marcil V. Food habits during treatment of childhood cancer: a critical review. Nutr Res Rev. 2019;32(2):265–281. https://doi.org/10.1017/S0954422419000131.
17. Vashura AY, Alymova JA. Nutrition features of young children with oncological diseases in the process of antitumor treatment. Meditsinskiy Sovet. 2019;(11):200–204. (In Russ.) https://doi.org/10.21518/2079-701X-2019-11-200-204.
18. Schcolnik-Cabrera A, Chávez-Blanco A, Domínguez-Gómez G, DueñasGonzález A. Understanding tumor anabolism and patient catabolism in cancer-associated cachexia. Am J Cancer Res. 2017;7(5):1107–1135. Available at: https://pubmed.ncbi.nlm.nih.gov/28560061.
19. Esper DH, Harb WA. The cancer cachexia syndrome: a review of metabolic and clinical manifestations. Nutr Clin Pract. 2005;20(4):369–376. https://doi.org/10.1177/0115426505020004369.
20. Curra M, Soares Junior LAV, Martins MD, Santos PSDS. Chemotherapy protocols and incidence of oral mucositis. An integrative review. Einstein. 2018;16(1):eRW4007. https://doi.org/10.1590/s1679-45082018rw4007.2025;19(19):296–302
21. Scaglioni S, De Cosmi V, Mazzocchi A. Nutritional Habits and Interventions in Childhood. Nutrients. 2022;14(13):2730. https://doi.org/10.3390/nu14132730.
22. Garg P, Williams JA, Satyavrat V. A pilot study to assess the utility and perceived effectiveness of a tool for diagnosing feeding difficulties in children. Asia Pac Fam Med. 2015;14(1):7. https://doi.org/10.1186/s12930-015-0024-5.
23. Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017;36(1):11–48. https://doi.org/10.1016/j.clnu.2016.07.015.
24. Becker P, Carney LN, Corkins MR, Monczka J, Smith E, Smith SE et al.; Academy of Nutrition and Dietetics; American Society for Parenteral and Enteral Nutrition. Consensus statement of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition: indicators recommended for the identification and documentation of pediatric malnutrition (undernutrition). Nutr Clin Pract. 2015;30(1):147–161. https://doi.org/10.1177/0884533614557642.
25. Damasco-Ávila E, Velasco-Hidalgo L, Zapata-Tarrés M, Cárdenas-Cardos R, Rivera-Luna R. Feeding difficulties and eating disorders in pediatric patients with cancer. Bol Med Hosp Infant Mex. 2019;76(3):113–119. https://doi.org/10.24875/BMHIM.19000072.
26. Kerzner B, Milano K, MacLean WC, Berall G, Stuart S, Chatoor I. A practical approach to classifying and managing feeding difficulties. Pediatrics. 2015;135(2):344–353. https://doi.org/10.1542/peds.2014-1630.
27. Aldridge VK, Dovey TM, Martin CI, Meyer C. Identifying clinically relevant feeding problems and disorders. J Child Health Care. 2010;14(3):261–270. https://doi.org/10.1177/1367493510370456.
28. Bryant-Waugh R, Markham L, Kreipe RE, Walsh BT. Feeding and eating disorders in childhood. Int J Eat Disord. 2010;43(2):98–111. https://doi.org/10.1002/eat.20795.
29. Chatoor I. Feeding disorders in infants and toddlers: diagnosis and treatment. Child Adolesc Psychiatr Clin N Am. 2002;11(2):163–183. https://doi.org/10.1016/s1056-4993(01)00002-5.
30. Pavlovskaya EV. Feeding disorders in children: modern approaches to diagnosis and management. Meditsinskiy Sovet. 2021;(17):32–39. (In Russ.) https://doi.org/10.21518/2079-701X-2021-17-2.
31. Klockars A, Wood EL, Gartner SN, McColl LK, Levine AS, Carpenter EA et al. Palatability of Goat’s versus Cow’s Milk: Insights from the Analysis of Eating Behavior and Gene Expression in the Appetite-Relevant Brain Circuit in Laboratory Animal Models. Nutrients. 2019;11(4):720. https://doi.org/10.3390/nu11040720.
32. Jung C, González Serrano A, Batard C, Seror E, Gelwane G, Poidvin A et al. Whole Goat Milk-Based Formula versus Whey-Based Cow Milk Formula: What Formula Do Infants Enjoy More? A Feasibility, Double-Blind, Randomized Controlled Trial. Nutrients. 2023;15(18):4057. https://doi.org/10.3390/nu15184057.
33. Rubio-Martín E, García-Escobar E, Ruiz de Adana MS, Lima-Rubio F, Peláez L, Caracuel AM et al. Comparison of the Effects of Goat Dairy and Cow Dairy Based Breakfasts on Satiety, Appetite Hormones, and Metabolic Profile. Nutrients. 2017;9(8):877. https://doi.org/10.3390/nu9080877.
34. Jung C, González Serrano A, Batard C, Seror E, Gelwane G, Poidvin A et al. Whole Goat Milk-Based Formula versus Whey-Based Cow Milk Formula: What Formula Do Infants Enjoy More? – A Feasibility, Double-Blind, Randomized Controlled Trial. Nutrients. 2023;15(18):4057. https://doi.org/10.3390/nu15184057.
35. Barrionuevo M, Alferez MJ, Lopez AI, Sanz SM, Campos MS. Beneficial effect of goat milk on nutritive utilization of iron and copper in malabsorption syndrome. J Dairy Sci. 2002;85(3):657–664. https://doi.org/10.3168/jds.s0022-0302(02)74120-9.
36. Sadovoy VV, Voblikova TV, Permyakov AV. Fatty Acid Composition of Goat and Sheep Milk: Transformation during Yogurt Production. Food Processing: Techniques and Technology. 2019;49(4):555–562. (In Russ.) https://doi.org/10.21603/2074-9414-2019-4-555-562.
37. Skidan IN, Gulyaev AE, Kaznacheev KS. Milk fat globules, as determinants of the nutritional and biological value of goat milk. Voprosy Pitaniia. 2015;84(2):81–95. (In Russ.) Available at: https://www.voprosy-pitaniya.ru/ru/jarticles_diet/350.html?SSr=07E90A17B4276.
38. Jirillo F, Magrone T. Anti-inflammatory and anti-allergic properties of donkey’s and goat’s milk. Endocr Metab Immune Disord Drug Targets. 2014;14(1):27–37. https://doi.org/10.2174/1871530314666140121143747.
39. St-Onge MP, Jones PJ. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr. 2002;132(3):329–332. https://doi.org/10.1093/jn/132.3.329.
40. Bellissimo N, Akhavan T. Effect of macronutrient composition on shortterm food intake and weight loss. Adv Nutr. 2015;6(3):302–308. https://doi.org/10.3945/an.114.006957.
41. Lemarié F, Beauchamp E, Legrand P, Rioux V. Revisiting the metabolism and physiological functions of caprylic acid (C8:0) with special focus on ghrelin octanoylation. Biochimie. 2016;120:40–48. https://doi.org/10.1016/j.biochi.2015.08.002.
42. Bech AM, Kristiansen KR. Milk protein polymorphism in Danish dairy cattle and the influence of genetic variants on milk yield. J Dairy Res. 1990;57(1):53–62. https://doi.org/10.1017/s0022029900026601.
43. Barnett MP, McNabb WC, Roy NC, Woodford KB, Clarke AJ. Dietary A1 β-casein affects gastrointestinal transit time, dipeptidyl peptidase-4 activity, and inflammatory status relative to A2 β-casein in Wistar rats. Int J Food Sci Nutr. 2014;65(6):720–727. https://doi.org/10.3109/09637486.2014.898260.
44. Jianqin S, Leiming X, Lu X, Yelland GW, Ni J, Clarke A. Erratum to: ‘Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows’ milk’. Nutr J. 2016;15(1):45. https://doi.org/10.1186/s12937-016-0164-y.
45. Novikova VP, Zavyalova AN, Balashov AL, Malanicheva TG, Churakova IYu, Samigullina SB. Tolerance and taste perception of goat milk-based original complementary food products: results of a multicenter clinical study. Russian Bulletin of Perinatology and Pediatrics. 2023;68(6):75–84. (In Russ.) https://doi.org/10.21508/1027-4065-2023-68-6-75-84.
46. van Leeuwen SS, Te Poele EM, Chatziioannou AC, Benjamins E, Haandrikman A, Dijkhuizen L. Goat Milk Oligosaccharides: Their Diversity, Quantity, and Functional Properties in Comparison to Human Milk Oligosaccharides. J Agric Food Chem. 2020;68(47):13469–13485. https://doi.org/10.1021/acs.jafc.0c03766.
Review
For citations:
Evdokimova TA, Kovtun TA, Andzhel AЕ, Yablokova YS. The possibility of feeding children with cancer, taking into account taste sensitivity at the outpatient stage. Meditsinskiy sovet = Medical Council. 2025;(19):296–302. (In Russ.) https://doi.org/10.21518/ms2025-461
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