Triple combination of vemurafenib, cobimetinib, and atezolizumab in real clinical practice in BRAF metastatic melanoma: updated 4-year OS analyses

I. V. Samoylenko; Yu. M. Kolontareva; E. V. Kogay; N. V. Zhukova; I. A. Utyashev; M. E. Ivannikov; K. V. Menshikov; M. V. Zinkevich; K. V. Orlova; Yu. V. Vakhabova; M. V. Volkonskiy; N. A. Beliaeva; E. A. Shmalts; E. V. Karabina; T. L. Moskovkina; K. A. Moshkova; O. V. Plishkina; V. D. Sychev; O. S. Cheplukhova; V. V. Chernova; A. N. Yurchenkov; K. G. Babina; N. A. Savelov; L. V. Demidov

Meditsinskiy sovet = Medical Council
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ISSN 2079-701X (Print)
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Samoylenko IV, Kolontareva YM, Kogay EV, Zhukova NV, Utyashev IA, Ivannikov ME, Menshikov KV, Zinkevich MV, Orlova KV, Vakhabova YV, Volkonskiy MV, Beliaeva NA, Shmalts EA, Karabina EV, Moskovkina TL, Moshkova KA, Plishkina OV, Sychev VD, Cheplukhova OS, Chernova VV, Yurchenkov AN, Babina KG, Savelov NA, Demidov LV. Triple combination of vemurafenib, cobimetinib, and atezolizumab in real clinical practice in BRAF metastatic melanoma: updated 4-year OS analyses. Meditsinskiy sovet = Medical Council. 2025;(21):110-122. (In Russ.) https://doi.org/10.21518/ms2025-537

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ISSN 2079-701X (Print)
ISSN 2658-5790 (Online)

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About the Authors

I. V. Samoylenko
Blokhin National Medical Research Center of Oncology; The Russian Melanoma Professional Association (Melanoma.PRO)
Russian Federation

Igor V. Samoylenko - Cand. Sci. (Med.), Senior Research Associate, Skin Tumour Department, Department of Medicinal Treatment, Blokhin National Medical Research Center of Oncology.

23, Kashirskoye Shosse, Moscow, 115478

Yu. M. Kolontareva
The Russian Melanoma Professional Association (Melanoma.PRO)
Russian Federation

Yulia M. Kolontareva - Employee, The Russian Melanoma Professional Association (Melanoma.PRO).

23, Kashirskoye Shosse, Moscow, 115478

E. V. Kogay
The Russian Melanoma Professional Association (Melanoma.PRO)
Russian Federation

Ekaterina V. Kogay - Employee, The Russian Melanoma Professional Association (Melanoma.PRO).

23, Kashirskoye Shosse, Moscow, 115478

N. V. Zhukova
City Clinical Oncology Dispensary
Russian Federation

Natalia V. Zhukova - Cand. Sci. (Med.), Oncologist, Head of the Expert Sector, City Clinical Oncology Dispensary.

3/5, 2^nd Berezovaya Alleya St., St Petersburg, 197022

I. A. Utyashev
Branch Office of “Hadassah Medical Ltd”
Russian Federation

Igor A. Utyashev - Cand. Sci. (Med.), Oncologist, Director of the Clinical Research Department, Leader of the Melanoma, Skin Tumors and Sarcoma Group, Hadassah Cancer Institute, Branch Office of “Hadassah Medical Ltd”.

46, Bldg. 1, Bolshoy Boulevard, Skolkovo Innovation Center Territory, Moscow, 121205

M. E. Ivannikov
Odintsovo Region Hospital
Russian Federation

Mikhail E. Ivannikov - Oncologist, Head of the Department of Antitumor Drug Therapy, Odintsovo Region Hospital.

17, Krasnogorskoe Shosse, Odintsovo, Moscow Region, 143007

K. V. Menshikov
Republican Clinical Oncology Dispensary
Russian Federation

Konstantin V. Menshikov - Cand. Sci. (Med.), Oncologist of the Department of Chemotherapy, Republican Clinical Oncology Dispensary.

73/1, Oktyabrya Ave., Ufa, 450054

M. V. Zinkevich
Leningrad Regional Clinical Oncological Dispensary
Russian Federation

Maksim V. Zinkevich - Cand. Sci. (Med.), Oncologist, Head of the Oncology Clinic, Leningrad Regional Clinical Oncological Dispensary.

37–39, Liteynyy Ave., St Petersburg, 191014

K. V. Orlova
Blokhin National Medical Research Center of Oncology; The Russian Melanoma Professional Association (Melanoma.PRO)
Russian Federation

Kristina V. Orlova - Dr. Sci. (Med.), Doctor – Pediatric Oncologist, Oncologist of the Skin Tumor Department, Senior Researcher, Blokhin National Medical Research Center of Oncology; Employee, The Russian Melanoma Professional Association (Melanoma.PRO).

23, Kashirskoye Shosse, Moscow, 115478

Yu. V. Vakhabova
European Medical Center
Russian Federation

Yuliya V. Vakhabova - Cand. Sci. (Med.), Oncologist, European Medical Center.

35, Shchepkin St., Moscow, 129110

M. V. Volkonskiy
Moscow City Oncological Hospital No. 62
Russian Federation

Mikhail V. Volkonskiy - Oncologist, Head of the Day Hospital for Antitumor Drug Therapy, Moscow City Oncological Hospital No.62.

27, Bldg. 1–30, Istra Settlement, Krasnogorsk Urban District, Moscow Region, 143515

N. A. Beliaeva
Orenburg Regional Clinical Oncological Dispensary
Russian Federation

Natalia A. Beliaeva - Oncologist, Orenburg Regional Clinical Oncological Dispensary.

11, Gagarin Ave., Orenburg, 460021

E. A. Shmalts
Multidisciplinary Clinical Medical Center “Medical City”
Russian Federation

Ekaterina A. Shmalts - Oncologist at the Clinic, Multidisciplinary Clinical Medical Center “Medical City”.

32, Barnaulskaya St., Tyumen, 625041

E. V. Karabina
Tula Regional Clinical Oncology Dispensary
Russian Federation

Elena V. Karabina - Head of the Department of Antitumor Drug Therapy, Tula Regional Clinical Oncology Dispensary.

201-A, Plekhanov St., Tula, 300040

T. L. Moskovkina
Kurgan Regional Oncology Center
Russian Federation

Tatyana L. Moskovkina - Oncologist of the Day Hospital at the Hospital (Antitumor Drug Therapy (Chemotherapy), Kurgan Regional Oncology Center.

33, Karbyshev St., Kurgan, 640014

K. A. Moshkova
Research Institute of Clinical Oncology “Nizhny Novgorod Regional Clinical Oncology Dispensary”
Russian Federation

Kseniya A. Moshkova - Oncologist at the Clinic, Research Institute of Clinical Oncology “Nizhny Novgorod Regional Clinical Oncology Dispensary”.

11/1, Delovaya St., Nizhny Novgorod, 603163

O. V. Plishkina
Oncology and Medical Radiology Center
Russian Federation

Olga V. Plishkina - Oncologist at the Day Hospital for Antitumor Drug Therapy, Oncology and Medical Radiology Center.

23, Stroiteley Ave., Kirov, 610045

V. D. Sychev
Tambov Regional Oncology Clinical Dispensary
Russian Federation

Vitaliy D. Sychev - Oncologist, Deputy Chief Physician for Outpatient Work, Tambov Regional Oncology Clinical Dispensary.

29V, Moskovskaya St., Tambov, 392000

O. S. Cheplukhova
Murmansk Regional Oncology Dispensary
Russian Federation

Oksana S. Cheplukhova - Oncologist in the Department of Antitumor Drug Therapy, Murmansk Regional Oncology Dispensary.

6, Bldg. 2, Pavlov St., Murmansk, 183047

V. V. Chernova
Regional Clinical Oncology Dispensary
Russian Federation

Vera V. Chernova - Head of the Day Hospital for Surgical Treatment Methods and Antitumor Drug Therapy, Regional Clinical Oncology Dispensary.

Bldg. 11, Sportivnaya St., Ryazan, 390011

A. N. Yurchenkov
Moscow City Oncological Hospital No. 62
Russian Federation

Aleksandr N. Yurchenkov - Oncologist of the Chemotherapy Department, Moscow City Oncological Hospital No.62.

27, Bldg. 1–30, Istra Settlement, Krasnogorsk Urban District, Moscow Region, 143515

K. G. Babina
Volgograd Regional Clinical Oncology Dispensary
Russian Federation

Kseniia G. Babina - Head of the Chemotherapy (Antitumor Drug Therapy) Department, Volgograd Regional Clinical Oncology Dispensary.

78, Zemlyachka St., Volgograd, 400138

N. A. Savelov
Moscow City Oncological Hospital No. 62
Russian Federation

Nikita A. Savelov - Head of the Pathological Anatomy Department, Moscow City Oncological Hospital No.62.

27, Bldg. 1–30, Istra Settlement, Krasnogorsk Urban District, Moscow Region, 143515

L. V. Demidov
Blokhin National Medical Research Center of Oncology; The Russian Melanoma Professional Association (Melanoma.PRO)
Russian Federation

Lev V. Demidov - Dr. Sci. (Med.), Professor, Chief Scientific Advisor of the Skin Tumors Department, Blokhin National Medical Research Center of Oncology.

23, Kashirskoye Shosse, Moscow, 115478

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