Prospects for pharmacotherapy of functional gastrointestinal disorders in children: The role of advanced oral formulations
https://doi.org/10.21518/ms2026-017
Abstract
The infectious process is often considered as the cause of the development of functional gastrointestinal disorders in childhood. To date, the pathogenetic basis of postinfectious functional gastrointestinal disorders has not been definitively established, and clinical studies evaluating the effectiveness of modern therapies for this pathology remain isolated. This article presents current approaches to treating functional gastrointestinal disorders that develop after acute intestinal infection (AII) and reflects experience in treating these conditions. The authors describe clinical cases demonstrating the diversity of functional gastrointestinal disorders in children. The first case is a 7-year-old girl diagnosed with an acute intestinal infection, which demonstrates the development and clinical manifestations of post-infectious irritable bowel syndrome. The second case is a 4-year-old girl complaining of constipation after an AII treated with antibiotics. A 6-year-old boy complained of abdominal pain and nausea that developed 3 months earlier after acute gastroenteritis. In the treatment of children, combination therapy was used, including the drug trimebutine in combination with a probiotic containing LGG, which represents the optimal treatment option for these disorders, ensuring ease of use, safety for children, and comprehensive restoration of the microbiota and intestinal motor function after the infectious process, which manifests itself in the form of rapid regression of symptoms such as pain, spasms, and bowel disorders.
About the Authors
A. I. Khavkin
Research Clinical Institute of Childhood; Belgorod State University
Russian Federation
Russian Federation
Anatoly I. Khavkin - Dr. Sci. (Med.), Professor, Head of the Moscow Regional Center of Pediatric Gastroenterology and Hepatology, Research Clinical Institute of Childhood; Professor of the Department of Pediatrics, Medical Institute, Belgorod State University.
62, Bolshaya Serpukhovskaya St., Moscow, 115093; 85, Pobedy St., Belgorod, 308015
A. V. Nalyotov
Gorky Donetsk State Medical University
Russian Federation
Russian Federation
Andrew V. Nalyotov - Dr. Sci. (Med.), Professor, Chief Consultant in Pediatric Gastroenterology of the Ministry of Health, Donetsk People's Republic, Head of the Department of Pediatrics No. 2, Gorky Donetsk State Medical University.
16, Illich Avе., Donetsk, 283003, Donetsk People`s Republic
P. I. Naletova
Donetsk Central City Clinical Hospital No. 1
Russian Federation
Russian Federation
Polina I. Naletova - Infectiologist, Donetsk Central City Clinical Hospital No. 1.
57, Artem St., Donetsk, 283003
References
1. Алексеева АА, Баранов АА, Барышникова НВ, Бельмер СВ, Богданова НМ, Вишнёва ЕА и др. Функциональная диспепсия у детей: клинические рекомендации. М.; 2025. Режим доступа: https://cr.minzdrav.gov.ru/view-cr/952_1.
2. Belmer SV, Gurova MM, Zvyagin AA, Kornienko EA, Nalyotov AV, Nizhevich AA et al. Irritable bowel syndrome in children: evolution of manifestations. Experimental and Clinical Gastroenterology. 2023;1(1):98–107. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-209-1-98-107.
3. Захарова ИН (ред.). Педиатрия: карманные рекомендации. М.: Ремедиум; 2019. 456 с.
4. Sheptulin AA, Vize-Khripunova MA. Postinfectious Irritable Bowel Syndrome: Polemic and Open Issues. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(6):41–46. (In Russ.) https://doi.org/10.22416/1382-4376-2021-31-6-41-46.
5. Khavkin AI, Gurova MM, Novikova VP. Functional abdominal pain in children. Pediatric Nutrition. 2021;19(2):62–75. (In Russ.) https://doi.org/10.20953/1727-5784-2021-2-62-75.
6. Sitkina EL, Ivanova RA, Sitkin SI, Kosenko IM, Savina AD, Pervunina TM et al. Acute norovirus gastroenteritis: epidemiology, clinical features, treatment and prevention. Clinical Practice in Pediatrics. 2025;20(1):83–98. (In Russ.) https://doi.org/10.20953/1817-7646-2025-1-83-98.
7. Khavkin AI, Blat SF. Enteric microbiocenosis and immunity. Russian Bulletin of Perinatology and Pediatrics. 2011;56(1):159–174. (In Russ.) Available at: https://www.elibrary.ru/nxytjl.
8. Makarova SG, Borovik TE. Intestinal dysbiosis in children with food allergy: pathogenetic aspects and modern correction methods. Current Pediatrics. 2008;7(2):82–92. (In Russ.) Available at: https://vsp.spr-journal.ru/jour/article/view/1373.
9. Huang JS, Bousvaros A, Lee JW, Diaz A, Davidson EJ. Efficacy of probiotic use in acute diarrhea in children: a meta-analysis. Dig Dis Sci. 2002;47(11):2625–2634. https://doi.org/10.1023/a:1020501202369.
10. Ruzhentsova TA, Abdrashitov DA, Meshkova NA, Gorelov AV. Probiotics administration in the prevention of seasonal acute respiratory infection. RMJ. 2019;(3):26–28. (In Russ.) Available at: https://www.rmj.ru/articles/pediatriya/Ispolyzovanie_probiotikov_v_profilaktike_sezonnyh_ostryh_respiratornyh_infekciy.
11. Juntunen M, Kirjavainen PV, Ouwehand AC, Salminen SJ, Isolauri E. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol. 2001;8:293–296. https://doi.org/10.1128/CDLI.8.2.293-296.2001.
12. Gorelov AV, Kanner ЕV, Maximov ML, Ermolaeva AS, Voznesenskaya AA, Dadasheva KN. Lactobacillus rhamnosus GG: clinical aspects of the use from the perspective of evidence-based medicine. Meditsinskiy Sovet. 2018;(17):66–73. (In Russ.) https://doi.org/10.21518/2079-701x-2018-17-66-73.
13. Kaibysheva VO, Nikonov EL. Probiotics from the standpoint of evidence-based medicine. Russian Journal of Evidence-Based Gastroenterology. 2019;8(3):45–54. (In Russ.) https://doi.org/10.17116/dokgastro2019803145.
14. Guarner F, Sanders ME, Szajewska H, Cohen H, Eliakim R, Herrera-deGuise C et al. World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics. J Clin Gastroenterol. 2024;58(6):533–553. https://doi.org/10.1097/MCG.0000000000002002.
15. Trukhan DI, Grishechkina IA, Bykhovtsev NA. Trimebutin in the treatment of irritable bowel syndrome and other functional gastrointestinal disorders. Meditsinskiy Sovet. 2016;(19):82–86. (In Russ.) https://doi.org/10.21518/2079-701X-2016-19-82-86.
16. Ивашкин ВТ, Шелыгин ЮА, Баранов АА, Намазова-Баранова ЛС, Ачкасов СИ, Алексеева ОП и др. Синдром раздраженного кишечника: дети, взрослые: клинические рекомендации. М.; 2024. Режим доступа: https://cr.minzdrav.gov.ru/preview-cr/892_1.
17. Новикова ВП, Барышникова НВ, Хавкин АИ, Гурова ММ, Калинина ЕЮ, Завьялова АН и др. Гастрит и дуоденит у детей: клинические рекомендации. М.; 2024. Режим доступа: https://cr.minzdrav.gov.ru/preview-cr/837_1.
18. Алексеева АА, Апханова ТВ, Баранов АА, Батаев СМ, Батышева ТТ, Бельмер СВ и др. Гастроэзофагеальная рефлюксная болезнь у детей: клинические рекомендации. М.; 2025. Режим доступа: https://cr.minzdrav.gov.ru/preview-cr/402_2.
19. Farrier S, Pretty IA, Lynch CD, Addy LD. Gagging during impression making: techniques for reduction. Dent Update. 2011;38(3):171–176. https://doi.org/10.12968/denu.2011.38.3.171.
20. Makmingjuan J, Wanich P, Sangmaneeet W. The ORS Intake Volume in Dehydrated Pediatric Patients: Comparison Between ORS Solution and Frozen ORS Pop. Songkla Med J. 2011;29(6):259–265. (In Thai). Available at: https://www.researchgate.net/publication/279677389_The_ORS_Intake_Volume_in_Dehydrated_Pediatric_Patients_Comparison.
21. Tipikina MYu, Korniyenko YeA. New aspects of the mechanisms of development and treatment of irritable bowel syndrome. Pediatrician. 2013;4(3):29–35. (In Russ.) https://doi.org/10.17816/PED4329-35.
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For citations:
Khavkin AI, Nalyotov AV, Naletova PI. Prospects for pharmacotherapy of functional gastrointestinal disorders in children: The role of advanced oral formulations. Meditsinskiy sovet = Medical Council. 2026;(1):133-138. (In Russ.) https://doi.org/10.21518/ms2026-017
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