Combination drugs in treatment of osteoarthrosis. Efficacy of Theraflex
https://doi.org/10.21518/2079-701X-2013-4-100-105
Abstract
OA is the most common form of joint disease and a major cause of morbidity and disability. A significant increase in the incidence of the disease is conditioned by rapid population aging and obesity pandemic. The main clinical symptoms of OA are pain and deformation of joints resulting in the functional failure. A thorough diagnosis process, evaluation of spread and severity of the pathological process, assessment of overall health and comorbidities, if any, are required in the treatment of OA to ensure correct choice of a course of treatment or a combination of treatments. Proven efficacy of monotherapy with chondroitin sulfate and glucosamine hydrochloride served as the platform for the development of combination drugs. The efficacy of the combination is supported by experimental and clinical data.
References
1. Gore M., Sadosky A., Tai K.-S. et al. Clinical comorbidities, painrelated pharmacotherapy and direct medical costs of pts with OA in clinical practice // OA&Cartil. V. 18. Suppl. 2. Oct. 2010. Abst. 281. S126.
2. W. Zhang, G. Nuki, R. Moskowitz et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009 // OA Cartil. 2010. №18(4). Р. 476–499.
3. Zhang W., Moskowitz R.W., Nuki G. et al. OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence-based, expert consensus guidelines // Osteoarthritis Cartilage. 2008. №16. Р. 137–162.
4. Zhang W., Nuki G., Moskowitz R.W. et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009 // Osteoarthritis Cartilage. 2010. №18. Р. 476–499.
5. Ronca F., Palmieri L., Panicucci P., Ronca G. Anti-inflammatory activity of chondroitin sulfate // Osteoarthritis Cartilage. 1998. №6 (Suppl. A). Р. 14–21.
6. Towheed T.E., Maxwell L., Anastassiades T.P. et al. Glucosamine therapy for treating osteoarthritis // Cochrane Database. Syst. Rev. 2005(2). CD002946.
7. McAlindon T.E., LaValley M.P., Gulin J.P., Felson D.T. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis // JAMA. 2000. №283(11). Р. 1469–1475.
8. Schneider H., Maheu E., Cucherat M. Symptom-Modifying Effect of Chondroitin Sulfate in Knee Osteoarthritis: A Meta-Analysis of Randomized Placebo-Controlled Trials Performed with Structum® // Open Rheumatol. J. 2012. №6. Р. 183–189.
9. Michel B.A., Stucki G., Frey D. et al. Chondroitins 4 and 6 sulfate in osteoarthritis of the
10. knee: a randomized, controlled trial // Arthritis Rheum. 2005. №52(3). Р. 779–786.
11. Kahan A., Uebelhart D., De Vathaire F. et al. Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial // Arthritis Rheum. 2009. №60(2). Р. 524–533.
12. Hochberg M.C. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration // Оsteoarthritis Cartilage. 2010. №18 (Suppl. 1). S28–31.
13. Das A. Jr., Hammad T.A. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis // Osteoarthritis Cartilage. 2000. Sep. №8(5). Р. 343–350.
14. Clegg D.O., Reda D.J., Harris C.L. et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis // N. Engl. J. Med. 2006. №354(8). Р. 795–808.
15. Беневоленская Л.И., Алексеева Л.И., Зайцева Е.М. Эффективность препарата терафлекс у больных остеоартрозом коленных и тазобедренных суставов (открытое рандомизированное исследование) // РМЖ. 2005. Т. 13. №8(232). С. 525–527.
16. Алексеева Л.И., Кашеварова Н.Г., Шарапова Е.П., Зайцева Е.М., Северинова М.В. Сравнение постоянного и интермиттирующего лечения больных остеоартрозом коленных суставов комбинированным препаратом «Терафлекс» // Научно-практическая ревматология. 2008. №3. С. 68–72.
Review
For citations:
Alekseyeva LI. Combination drugs in treatment of osteoarthrosis. Efficacy of Theraflex. Meditsinskiy sovet = Medical Council. 2013;(4):100-105. (In Russ.) https://doi.org/10.21518/2079-701X-2013-4-100-105
Views:
507
Email this article 