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Modern skincare strategies for aging skin: The role of biotic complexes and plant extracts

https://doi.org/10.21518/ms2026-015

Abstract

Introduction. Skin aging is a multifactorial process, with oxidative stress playing a particularly crucial role. The formation of reactive oxygen species (ROS) initiates a cascade of reactions leading to collagen degradation and elastin disorganization, thereby contributing to visible signs of aging. A rational skincare approach, incorporating gentle cleansing and hydration combined with active ingredient action, can slow down the aging processes.
Aim. To evaluate the efficacy of a skincare line combining a biotic complex and plant extracts in caring for mature skin.
Materials and methods. 30 women aged 30 to 55 years (mean age of 42.5 years), exhibiting age-related skin changes. During the 21 days they applied gentle cleansing foam, soothing, moisturizing toner, boost-serum and eye skin care cream and during the following 7 days only foam and toner. Every week there were an assessment of epidermal barrier parameters using the Multi Skin Test Center 750/IMATE 6602 diagnostic system (Germany) and in 28th day of the study satisfaction with the topical products was evaluated via the TTSI-10 questionnaire.
Results. At baseline, the average skin hydration level was 41.3 UE, sebum production was 26.1 UE, and elasticity was 39.2 UE. At the 21st day hydration level increased by 35.6%, and elasticity improved by 21.4%. Sebum level showed minimal change. Moreover, the epidermal barrier parameters showed minimal changes between days 21 and 28. Visually, participants reported filling of fine wrinkles and decrease in pigmentation intensity. During the study, no adverse reactions were reported.
Conclusions. The anti-aging potential of the studied cosmetic products is based on the synergistic action of plant extracts, a biotic complex, and active moisturizing components. The significant improvements observed in epidermal barrier parameters validate the importance of a comprehensive approach to caring for aging skin.

About the Authors

D. V. Zaslavsky
Saint Petersburg State Pediatric Medical University
Russian Federation

Denis V. Zaslavsky, Dr. Sci. (Med.), Professor, Honored Doctor of Russian Federation, Head of the Department of Dermatovenereology 

2, Litovskaya St., St Petersburg, 194100



A. V. Taganov
Russian Academy of Natural Sciences
Russian Federation

Alexey V. Taganov, Dr. Sci. (Med.), Professor, Chairman of the Department of Fundamental Dermatovenereology and Cosmetology 

29/16, Sivtsev Vrazhek Lane, Moscow, 119002



D. V. Kozlova
Saint Petersburg State Pediatric Medical University; Russian Scientific Center of Radiology and Surgical Technologies named after Academician A.M. Granov
Russian Federation

Darya V. Kozlova, Dermatovenereologist, Assistant of the Department of Dermatovenereology; Postgraduate Student of the Department of Radiology, Surgery and Oncology 

2, Litovskaya St., St Petersburg, 194100;
70, Leningradskaya St., Pesochnyy Settlement, St Petersburg, 197758



N. S. Abdukaeva
Saint Petersburg State Pediatric Medical University
Russian Federation

Nelly S. Abdukaeva, Cand. Sci. (Med.), Associate Professor, Head of the Department of Medical Biology 

2, Litovskaya St., St Petersburg, 194100



N. N. Aletskiy-Milyutin
VERTEX JSC
Russian Federation

Nikolay N. Aletskiy-Milyutin, Medical Advisor, Senior Specialist in the Medical Business Support Department 

62а, the road to Kamenka, St Petersburg, 194294



A. N. Haradovich
Polotsk Central City Hospital
Belarus

Alexey N. Haradovich, Head of the Department of Dermatovenerology, Polotsk Central City Hospital 

15, Oktyabrskaya St., Polotsk, 211415



E. D. Zaslavskaya
Saint Petersburg State Pediatric Medical University
Russian Federation

Elizaveta D. Zaslavskaya, Student 

2, Litovskaya St., St Petersburg, 194100



Е. А. Lyamina
Saint Petersburg State Pediatric Medical University
Russian Federation

Ekaterina A. Lyamina, Senior Assistant of the Department of Dermatovenereology 

2, Litovskaya St., St Petersburg, 194100



V. V. Poluektova
Saint Petersburg State Pediatric Medical University
Russian Federation

Viktoria V. Poluektova, Student 

2, Litovskaya St., St Petersburg, 194100



E. A. Erofeeva
Saint Petersburg State Pediatric Medical University
Russian Federation

Elizaveta A. Erofeeva, Student 

2, Litovskaya St., St Petersburg, 194100



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Review

For citations:


Zaslavsky DV, Taganov AV, Kozlova DV, Abdukaeva NS, Aletskiy-Milyutin NN, Haradovich AN, Zaslavskaya ED, Lyamina ЕА, Poluektova VV, Erofeeva EA. Modern skincare strategies for aging skin: The role of biotic complexes and plant extracts. Meditsinskiy sovet = Medical Council. 2026;(2):137-144. (In Russ.) https://doi.org/10.21518/ms2026-015

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