Association of MCP-1, VEGF-A, and IL-10 with progressive pulmonary fibrosis in hypersensitivity pneumonitis
https://doi.org/10.21518/ms2026-183
Abstract
Introduction. Hypersensitivity pneumonitis (HP) is the most common interstitial lung disease (ILD), which is characterized by the development of progressive pulmonary fibrosis (PPF).
Aim. To study the relationship between monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF-A) and interleukin-10 (IL-10) in serum and PPF criteria in patients with HP.
Materials and methods. The study included 51 patients with GP, the diagnosis of PPF was established based on the diagnostic criteria of the American Thoracic Society (2022), and 12 patients with idiopathic pulmonary fibrosis (IPF). Quantitative determination of the level of MCP-1, VEGF-A and IL-10 in the blood serum was performed using Vector-Best kits (Russia) on the enzyme immunoassay analyzer “Hydro Flex” (TECAN, Austria). Statistical data processing was performed using Statistica 10.0 software.
Results. Baseline levels of MCP-1 and IL-10 (7.11 ± 2.26 vs. 6.53 ± 2.62 pg/ml) in the blood serum were comparable in IPF and GP with PPF (p = 0.36 and p = 0.18, respectively). MCP-1 levels were significantly higher in IPF and GP with PPF (291.3 ± 68.4 vs. 270.9 ± 54.2 pg/ml) compared to GP without PFF (220,9 ± 42,8 pg/ml; p = 0.005 and p = 0.008). A negative correlation was found between MCP-1 and IL-10 levels and dynamics FVC and DLCO over 12 months.
Conclusion. Increased serum MCP-1 and IL-10 levels in patients with PPF in GP are statistically significantly associated with a decrease in FVC ≥ 5% and DLCO ≥ 10% over a 12-month period.
Supporting agencies: The study was carried out with the support of the administration of the State Budgetary Healthcare Institution “Research Institute – Regional Clinical Hospital No. 1 named after S.V. Ochapovsky”
About the Authors
E. V. Bolotova
Kuban State Medical University
Russian Federation
Russian Federation
Elena V. Bolotova - Dr. Sci. (Med.), Professor, Professor of the Department of Therapy No. 1.
4, Mitrofan Sedin St., Krasnodar, 350063
Yu. G. Yurkova
Kuban State Medical University; Ochapovsky Regional Clinic Hospital No. 1
Russian Federation
Russian Federation
Yulia G. Yurkova - Postgraduate Student of the Department of Pulmonology, Kuban SMU; Ochapovsky Regional Clinic Hospital No. 1.
4, Mitrofan Sedin St., Krasnodar, 350063, Pulmonologist; 167, 1st Maya St., Krasnodar, 350086
I. V. Gilevich
Kuban State Medical University; Ochapovsky Regional Clinic Hospital No. 1
Russian Federation
Russian Federation
Irina V. Gilevich - Cand. Sci. (Med.), Head of the Laboratory for Development and Study of New Treatment Technologies, Ochapovsky RCH No. 1; Assistant Professor, Department of Oncology with the Course of Thoracic Surgery, Faculty of Advanced Training and Professional Retraining of Specialists, KSMU.
167, 1 Maya St., Krasnodar, 350086; 4, Mitrofan Sedin St., Krasnodar, 350063
L. V. Shulzhenko
Kuban State Medical University; Ochapovsky Regional Clinic Hospital No. 1
Russian Federation
Russian Federation
Larisa V. Shulzhenko - Dr. Sci. (Med.), Head of the Department of Pulmonology Kuban SMU; Head of the Department of Pulmonology, Ochapovsky RCH No. 1.
4, Mitrofan Sedin St., Krasnodar, 350063; 167, 1st Maya St., Krasnodar, 350086
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For citations:
Bolotova EV, Yurkova YG, Gilevich IV, Shulzhenko LV. Association of MCP-1, VEGF-A, and IL-10 with progressive pulmonary fibrosis in hypersensitivity pneumonitis. Meditsinskiy sovet = Medical Council. 2026;(9):158-164. (In Russ.) https://doi.org/10.21518/ms2026-183
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